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• W2111336617 abstract "Determining the mechanism of treatment failure of VEGF signaling inhibitors for malignant glioma patients would provide insight into approaches to overcome therapeutic resistance. In this study, we demonstrate that human glioblastoma tumors failing bevacizumab have an increase in the mean percentage of p-STAT3-expressing cells compared to samples taken from patients failing non-antiangiogenic therapy containing regimens. Likewise, in murine xenograft models of glioblastoma, the mean percentage of p-STAT3-expressing cells in the gliomas resistant to antiangiogenic therapy was markedly elevated relative to controls. Administration of the JAK/STAT3 inhibitor AZD1480 alone and in combination with cediranib reduced tumor hypoxia and the infiltration of VEGF inhibitor-induced p-STAT3 macrophages. Thus, the combination of AZD1480 with cediranib markedly reduced tumor volume, and microvascular density, indicating that up regulation of the STAT3 pathway can mediate resistance to antiangiogenic therapy and combinational approaches may delay or overcome resistance." @default.
• W2111336617 created "2016-06-24" @default.
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• W2111336617 date "2012-09-19" @default.
• W2111336617 modified "2023-10-01" @default.
• W2111336617 title "Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma" @default.
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• W2111336617 doi "https://doi.org/10.18632/oncotarget.663" @default.
• W2111336617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3660053" @default.
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• W2111336617 hasPublicationYear "2012" @default.
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