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- W2111342414 abstract "Fibrofolliculoma is a benign skin lesion that, when multiple, can be part of the Birt-Hogg-Dube syndrome. We report on a case of solitary fibrofolliculoma arisen on the nose of a 63-year-old woman, with peculiar histological and immunohistochemical features. The lesion was characterized by the presence of bizarre multinucleated perifollicular stromal cells, positive for factor XIIIa, in a background of CD34-positive cells, and by a peripheral population of CD34-positive spindle cells organized in fascicles haphazardly infiltrating the deep dermis, and surrounded by scattered factor XIIIa-positive dendrocytes. We consider the bizarre perifollicular cellular component as an ‘ancient’ feature of fibrofolliculoma, hypothesis corroborated by the co-expression of CD34 and factor XIIIa, whereas the peripheral spindle cell fascicles represent a pseudosarcomatous proliferation of CD34-positive cells, normally surrounding adnexal structures, stimulated by factor XIIIa-positive dendrocytes. Cesinaro AM, Rusev BC, Kutzner H. Fibrofolliculoma with ancient/pseudosarcomatous features." @default.
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- W2111342414 date "2009-10-15" @default.
- W2111342414 modified "2023-09-27" @default.
- W2111342414 title "Fibrofolliculoma with ancient/pseudosarcomatous features" @default.
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- W2111342414 doi "https://doi.org/10.1111/j.1600-0560.2009.01453.x" @default.
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