FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111346111> ?p ?o ?g. }

• W2111346111 endingPage "114" @default.
• W2111346111 startingPage "108" @default.
• W2111346111 abstract "The neuromuscular junction (NMJ) is structured and powered to transduce electrical activity from the distal nerve terminal of a motor neurone via the neuromuscular cleft to the post-junctional muscle membrane to ultimately generate muscle contraction. Our understanding of this complex function has expanded over many years, and the NMJ has served as a prototype for how different synapses operate in the peripheral and central nervous systems. The NMJ has a presynaptic part which is synonymous with the distal nerve ending, being responsible for neurotransmitter synthesis, packaging into vesicles, and subsequent vesicle transportation to active release sites where vesicle docking, fusion, and release of acetylcholine and other co-released transmitters finally take place. The synaptic cleft, filled with large molecular complexes that guarantee ultrastructural NMJ arrangement and signal transduction, allows for rapid diffusion and degradation of the neurotransmitter. The postsynaptic part consists of a folded muscle membrane into which nicotinic acetylcholine receptors (nAChRs) directly opposite the presynaptic active release sites are mounted and fixed by a cytoskeleton. This specialized postsynaptic region is closely associated with the perijunctional zone where a high density of sodium channels promote and amplify the signal in order to guarantee the propagation of the electrical activity to generate muscle contraction. The transduction process is maintained at load (i.e. high stimulus frequency) by a presynaptic mechanism allowing for sustained transmitter release over time at high demand. This positive feedback mechanism relies on neuronal nAChRs present on the distal nerve terminal, whereas the continuation of the transduction process at the postsynaptic part relies on the classical muscle type nAChR. In this review, we will focus on recent findings of potential clinical importance that will advance our understanding of the effects of neuromuscular blocking agents and neuromuscular monitoring and also our management of disorders of the neuromuscular system within anaesthesia and intensive care." @default.
• W2111346111 created "2016-06-24" @default.
• W2111346111 creator A5015602415 @default.
• W2111346111 creator A5026917181 @default.
• W2111346111 date "2009-07-01" @default.
• W2111346111 modified "2023-09-30" @default.
• W2111346111 title "Current concepts in neuromuscular transmission" @default.
• W2111346111 cites W1799536240 @default.
• W2111346111 cites W1964586474 @default.
• W2111346111 cites W1967637447 @default.
• W2111346111 cites W1969128083 @default.
• W2111346111 cites W1982683622 @default.
• W2111346111 cites W1990099504 @default.
• W2111346111 cites W1992067885 @default.
• W2111346111 cites W1992338919 @default.
• W2111346111 cites W2000261863 @default.
• W2111346111 cites W2002797282 @default.
• W2111346111 cites W2008411984 @default.
• W2111346111 cites W2010672819 @default.
• W2111346111 cites W2031722646 @default.
• W2111346111 cites W2039431039 @default.
• W2111346111 cites W2039749725 @default.
• W2111346111 cites W2045297807 @default.
• W2111346111 cites W2046075911 @default.
• W2111346111 cites W2049871722 @default.
• W2111346111 cites W2053589875 @default.
• W2111346111 cites W2054105056 @default.
• W2111346111 cites W2057524299 @default.
• W2111346111 cites W2061130901 @default.
• W2111346111 cites W2063972241 @default.
• W2111346111 cites W2066662207 @default.
• W2111346111 cites W2068829473 @default.
• W2111346111 cites W2069757888 @default.
• W2111346111 cites W2073295417 @default.
• W2111346111 cites W2076658236 @default.
• W2111346111 cites W2079413658 @default.
• W2111346111 cites W2086887229 @default.
• W2111346111 cites W2090279005 @default.
• W2111346111 cites W2091723337 @default.
• W2111346111 cites W2092325050 @default.
• W2111346111 cites W2095771277 @default.
• W2111346111 cites W2116868280 @default.
• W2111346111 cites W2131003845 @default.
• W2111346111 cites W2150860493 @default.
• W2111346111 cites W2154100802 @default.
• W2111346111 cites W2172239192 @default.
• W2111346111 doi "https://doi.org/10.1093/bja/aep150" @default.
• W2111346111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19546202" @default.
• W2111346111 hasPublicationYear "2009" @default.
• W2111346111 type Work @default.
• W2111346111 sameAs 2111346111 @default.
• W2111346111 citedByCount "86" @default.
• W2111346111 countsByYear W21113461112012 @default.
• W2111346111 countsByYear W21113461112013 @default.
• W2111346111 countsByYear W21113461112014 @default.
• W2111346111 countsByYear W21113461112015 @default.
• W2111346111 countsByYear W21113461112016 @default.
• W2111346111 countsByYear W21113461112017 @default.
• W2111346111 countsByYear W21113461112018 @default.
• W2111346111 countsByYear W21113461112019 @default.
• W2111346111 countsByYear W21113461112020 @default.
• W2111346111 countsByYear W21113461112021 @default.
• W2111346111 countsByYear W21113461112022 @default.
• W2111346111 countsByYear W21113461112023 @default.
• W2111346111 crossrefType "journal-article" @default.
• W2111346111 hasAuthorship W2111346111A5015602415 @default.
• W2111346111 hasAuthorship W2111346111A5026917181 @default.
• W2111346111 hasBestOaLocation W21113461111 @default.
• W2111346111 hasConcept C112592302 @default.
• W2111346111 hasConcept C130316041 @default.
• W2111346111 hasConcept C134018914 @default.
• W2111346111 hasConcept C148785051 @default.
• W2111346111 hasConcept C169760540 @default.
• W2111346111 hasConcept C170493617 @default.
• W2111346111 hasConcept C17077164 @default.
• W2111346111 hasConcept C187102610 @default.
• W2111346111 hasConcept C187541742 @default.
• W2111346111 hasConcept C197341189 @default.
• W2111346111 hasConcept C200170125 @default.
• W2111346111 hasConcept C2775910092 @default.
• W2111346111 hasConcept C2776219046 @default.
• W2111346111 hasConcept C2777240379 @default.
• W2111346111 hasConcept C2993285035 @default.
• W2111346111 hasConcept C3020341438 @default.
• W2111346111 hasConcept C41625074 @default.
• W2111346111 hasConcept C529278444 @default.
• W2111346111 hasConcept C55493867 @default.
• W2111346111 hasConcept C80161118 @default.
• W2111346111 hasConcept C86803240 @default.
• W2111346111 hasConcept C95444343 @default.
• W2111346111 hasConceptScore W2111346111C112592302 @default.
• W2111346111 hasConceptScore W2111346111C130316041 @default.
• W2111346111 hasConceptScore W2111346111C134018914 @default.
• W2111346111 hasConceptScore W2111346111C148785051 @default.
• W2111346111 hasConceptScore W2111346111C169760540 @default.
• W2111346111 hasConceptScore W2111346111C170493617 @default.
• W2111346111 hasConceptScore W2111346111C17077164 @default.
• W2111346111 hasConceptScore W2111346111C187102610 @default.

• next