FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111346935> ?p ?o ?g. }

• W2111346935 endingPage "4363" @default.
• W2111346935 startingPage "4357" @default.
• W2111346935 abstract "ABSTRACT Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer. There is increased T-cell infiltration at the site of infection with H. pylori . CCR6, a specific β-chemokine receptor for CCL20 (MIP-3α/LARC/exodus), has recently been reported to mediate lymphocyte homeostasis and immune responses in mucosal tissue, and it may play a role in chemokine-mediated lymphocyte trafficking during gastric inflammation. In this study, we investigated the role of CCR6 and its ligand, CCL20, in inducing an inflammatory response in the gastric mucosa during H. pylori infection. Gastric infiltrating T lymphocytes were isolated from endoscopic biopsy specimens of H. pylori gastritis patients and analyzed for the expression of the CCR6 chemokine receptor. Our results demonstrated that there was significantly increased CCR6 expression in CD3 + T cells infiltrating the gastric mucosa, and the CCR6 ligand, the CCL20 chemokine, was selectively expressed in inflamed gastric tissues. The production of CCL20 was upregulated in response to H. pylori in gastric epithelial cells when there was stimulation by the proinflammatory cytokines interleukin-1β and tumor necrosis factor alpha. Furthermore, recombinant CCL20 induced lymphocyte chemotaxis migration in fresh gastric T cells ex vivo, indicating that the gastric T cells could migrate toward inflammatory sites via CCR6/CCL20 interaction. Our results suggest that the interaction between CCL20 and CCR6 may play a role in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection." @default.
• W2111346935 created "2016-06-24" @default.
• W2111346935 creator A5014941177 @default.
• W2111346935 creator A5022857093 @default.
• W2111346935 creator A5029901816 @default.
• W2111346935 creator A5044827208 @default.
• W2111346935 creator A5045578865 @default.
• W2111346935 creator A5077314509 @default.
• W2111346935 creator A5084913323 @default.
• W2111346935 date "2007-09-01" @default.
• W2111346935 modified "2023-10-18" @default.
• W2111346935 title "Upregulation of CCL20 and Recruitment of CCR6 ⁺ Gastric Infiltrating Lymphocytes in <i>Helicobacter pylori</i> Gastritis" @default.
• W2111346935 cites W1514708659 @default.
• W2111346935 cites W1535141082 @default.
• W2111346935 cites W1538013217 @default.
• W2111346935 cites W1556962520 @default.
• W2111346935 cites W1586392520 @default.
• W2111346935 cites W1602835962 @default.
• W2111346935 cites W1971271340 @default.
• W2111346935 cites W1972496142 @default.
• W2111346935 cites W1978420570 @default.
• W2111346935 cites W1998470464 @default.
• W2111346935 cites W2005659566 @default.
• W2111346935 cites W2006219739 @default.
• W2111346935 cites W2007348558 @default.
• W2111346935 cites W2020617877 @default.
• W2111346935 cites W2028247108 @default.
• W2111346935 cites W2029499500 @default.
• W2111346935 cites W2046201188 @default.
• W2111346935 cites W2059413226 @default.
• W2111346935 cites W2064836776 @default.
• W2111346935 cites W2073382629 @default.
• W2111346935 cites W2103384599 @default.
• W2111346935 cites W2103555767 @default.
• W2111346935 cites W2105499867 @default.
• W2111346935 cites W2108583998 @default.
• W2111346935 cites W2113045990 @default.
• W2111346935 cites W2124617998 @default.
• W2111346935 cites W2128677941 @default.
• W2111346935 cites W2131015336 @default.
• W2111346935 cites W2133260339 @default.
• W2111346935 cites W2135410482 @default.
• W2111346935 cites W2140075294 @default.
• W2111346935 cites W2146460418 @default.
• W2111346935 cites W2147022432 @default.
• W2111346935 cites W2154459623 @default.
• W2111346935 cites W2157069655 @default.
• W2111346935 cites W2164280295 @default.
• W2111346935 cites W2227704724 @default.
• W2111346935 cites W2320937221 @default.
• W2111346935 cites W243335379 @default.
• W2111346935 cites W2948387191 @default.
• W2111346935 doi "https://doi.org/10.1128/iai.01660-06" @default.
• W2111346935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1951156" @default.
• W2111346935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17562763" @default.
• W2111346935 hasPublicationYear "2007" @default.
• W2111346935 type Work @default.
• W2111346935 sameAs 2111346935 @default.
• W2111346935 citedByCount "53" @default.
• W2111346935 countsByYear W21113469352012 @default.
• W2111346935 countsByYear W21113469352013 @default.
• W2111346935 countsByYear W21113469352014 @default.
• W2111346935 countsByYear W21113469352015 @default.
• W2111346935 countsByYear W21113469352016 @default.
• W2111346935 countsByYear W21113469352017 @default.
• W2111346935 countsByYear W21113469352018 @default.
• W2111346935 countsByYear W21113469352019 @default.
• W2111346935 countsByYear W21113469352020 @default.
• W2111346935 countsByYear W21113469352021 @default.
• W2111346935 countsByYear W21113469352022 @default.
• W2111346935 countsByYear W21113469352023 @default.
• W2111346935 crossrefType "journal-article" @default.
• W2111346935 hasAuthorship W2111346935A5014941177 @default.
• W2111346935 hasAuthorship W2111346935A5022857093 @default.
• W2111346935 hasAuthorship W2111346935A5029901816 @default.
• W2111346935 hasAuthorship W2111346935A5044827208 @default.
• W2111346935 hasAuthorship W2111346935A5045578865 @default.
• W2111346935 hasAuthorship W2111346935A5077314509 @default.
• W2111346935 hasAuthorship W2111346935A5084913323 @default.
• W2111346935 hasBestOaLocation W21113469351 @default.
• W2111346935 hasConcept C12823836 @default.
• W2111346935 hasConcept C13373296 @default.
• W2111346935 hasConcept C203014093 @default.
• W2111346935 hasConcept C2776409635 @default.
• W2111346935 hasConcept C2776914184 @default.
• W2111346935 hasConcept C2778677798 @default.
• W2111346935 hasConcept C2779422922 @default.
• W2111346935 hasConcept C2781443798 @default.
• W2111346935 hasConcept C54355233 @default.
• W2111346935 hasConcept C55493867 @default.
• W2111346935 hasConcept C83360876 @default.
• W2111346935 hasConcept C86803240 @default.
• W2111346935 hasConcept C94205230 @default.
• W2111346935 hasConceptScore W2111346935C12823836 @default.
• W2111346935 hasConceptScore W2111346935C13373296 @default.
• W2111346935 hasConceptScore W2111346935C203014093 @default.
• W2111346935 hasConceptScore W2111346935C2776409635 @default.
• W2111346935 hasConceptScore W2111346935C2776914184 @default.

• next