FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111363921> ?p ?o ?g. }

• W2111363921 endingPage "410" @default.
• W2111363921 startingPage "405" @default.
• W2111363921 abstract "Plasmacytoid dendritic cells (pDCs) are critical in controlling adaptive immunity, but the mechanisms governing cytokine expression remain incompletely defined. Analogues of prostaglandin (PG)I₂, such as iloprost, can modulate functions of myeloid dendritic cells, but their involvement in the regulation of human pDCs remains unknown. To this end, the regulatory role of PGI₂ analogues on cytokine expression in pDCs was investigated. Circulating pDCs were magnetically sorted with BDCA-4 cell isolation kits from human peripheral blood mononuclear cells and treated with varying concentrations of iloprost with or without the addition of Toll-like receptor agonists, or an I prostanoid (IP) receptor antagonist, CAY10449. The levels of tumour necrosis factor (TNF)-α, interferon (IFN)-α and interleukin (IL)-10 were measured by ELISA. Iloprost induced IL-10 expression, but suppressed CpG oligodeoxynucleotide- (or imiquimod-) induced TNF-α and IFN-α production in pDCs. This effect was reversed by the addition of CAY10449. Forskolin, a cyclic adenosine monophosphate activator, conferred a similar modulating effect to that noted in iloprost-treated pDCs, although a higher concentration of forskolin was required to exert the same effect. Iloprost enhanced interleukin-10 and suppressed Toll-like receptor-mediated tumour necrosis factor-α and interferon-α production of human plasmacytoid dendritic cells <i>via</i> the I prostanoid receptor and, in part, the cyclic adenosine monophosphate pathway." @default.
• W2111363921 created "2016-06-24" @default.
• W2111363921 creator A5004195587 @default.
• W2111363921 creator A5008815036 @default.
• W2111363921 creator A5009195847 @default.
• W2111363921 creator A5025573759 @default.
• W2111363921 creator A5034264503 @default.
• W2111363921 creator A5036851963 @default.
• W2111363921 creator A5049576426 @default.
• W2111363921 date "2008-09-17" @default.
• W2111363921 modified "2023-10-06" @default.
• W2111363921 title "Regulation of cytokine expression in human plasmacytoid dendritic cells by prostaglandin I2 analogues" @default.
• W2111363921 cites W1535284466 @default.
• W2111363921 cites W1627330887 @default.
• W2111363921 cites W1653683821 @default.
• W2111363921 cites W1968536379 @default.
• W2111363921 cites W1971900170 @default.
• W2111363921 cites W1991876285 @default.
• W2111363921 cites W1994495052 @default.
• W2111363921 cites W2022729636 @default.
• W2111363921 cites W2048143404 @default.
• W2111363921 cites W2051049597 @default.
• W2111363921 cites W2076744535 @default.
• W2111363921 cites W2081793615 @default.
• W2111363921 cites W2082636822 @default.
• W2111363921 cites W2102996167 @default.
• W2111363921 cites W2111220263 @default.
• W2111363921 cites W2121612337 @default.
• W2111363921 cites W2122735365 @default.
• W2111363921 cites W2122980018 @default.
• W2111363921 cites W2137594178 @default.
• W2111363921 cites W2145609263 @default.
• W2111363921 cites W2158722408 @default.
• W2111363921 cites W2162129085 @default.
• W2111363921 cites W2331166595 @default.
• W2111363921 doi "https://doi.org/10.1183/09031936.00070008" @default.
• W2111363921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19181914" @default.
• W2111363921 hasPublicationYear "2008" @default.
• W2111363921 type Work @default.
• W2111363921 sameAs 2111363921 @default.
• W2111363921 citedByCount "24" @default.
• W2111363921 countsByYear W21113639212012 @default.
• W2111363921 countsByYear W21113639212013 @default.
• W2111363921 countsByYear W21113639212014 @default.
• W2111363921 countsByYear W21113639212015 @default.
• W2111363921 countsByYear W21113639212016 @default.
• W2111363921 countsByYear W21113639212017 @default.
• W2111363921 countsByYear W21113639212018 @default.
• W2111363921 countsByYear W21113639212020 @default.
• W2111363921 countsByYear W21113639212021 @default.
• W2111363921 crossrefType "journal-article" @default.
• W2111363921 hasAuthorship W2111363921A5004195587 @default.
• W2111363921 hasAuthorship W2111363921A5008815036 @default.
• W2111363921 hasAuthorship W2111363921A5009195847 @default.
• W2111363921 hasAuthorship W2111363921A5025573759 @default.
• W2111363921 hasAuthorship W2111363921A5034264503 @default.
• W2111363921 hasAuthorship W2111363921A5036851963 @default.
• W2111363921 hasAuthorship W2111363921A5049576426 @default.
• W2111363921 hasBestOaLocation W21113639211 @default.
• W2111363921 hasConcept C126322002 @default.
• W2111363921 hasConcept C134018914 @default.
• W2111363921 hasConcept C170493617 @default.
• W2111363921 hasConcept C17991360 @default.
• W2111363921 hasConcept C185592680 @default.
• W2111363921 hasConcept C203014093 @default.
• W2111363921 hasConcept C2776991684 @default.
• W2111363921 hasConcept C2778266237 @default.
• W2111363921 hasConcept C2778690821 @default.
• W2111363921 hasConcept C2779276759 @default.
• W2111363921 hasConcept C2780664492 @default.
• W2111363921 hasConcept C2781103887 @default.
• W2111363921 hasConcept C2781128415 @default.
• W2111363921 hasConcept C71924100 @default.
• W2111363921 hasConcept C86803240 @default.
• W2111363921 hasConcept C95444343 @default.
• W2111363921 hasConceptScore W2111363921C126322002 @default.
• W2111363921 hasConceptScore W2111363921C134018914 @default.
• W2111363921 hasConceptScore W2111363921C170493617 @default.
• W2111363921 hasConceptScore W2111363921C17991360 @default.
• W2111363921 hasConceptScore W2111363921C185592680 @default.
• W2111363921 hasConceptScore W2111363921C203014093 @default.
• W2111363921 hasConceptScore W2111363921C2776991684 @default.
• W2111363921 hasConceptScore W2111363921C2778266237 @default.
• W2111363921 hasConceptScore W2111363921C2778690821 @default.
• W2111363921 hasConceptScore W2111363921C2779276759 @default.
• W2111363921 hasConceptScore W2111363921C2780664492 @default.
• W2111363921 hasConceptScore W2111363921C2781103887 @default.
• W2111363921 hasConceptScore W2111363921C2781128415 @default.
• W2111363921 hasConceptScore W2111363921C71924100 @default.
• W2111363921 hasConceptScore W2111363921C86803240 @default.
• W2111363921 hasConceptScore W2111363921C95444343 @default.
• W2111363921 hasIssue "2" @default.
• W2111363921 hasLocation W21113639211 @default.
• W2111363921 hasLocation W21113639212 @default.
• W2111363921 hasOpenAccess W2111363921 @default.
• W2111363921 hasPrimaryLocation W21113639211 @default.
• W2111363921 hasRelatedWork W2021624237 @default.
• W2111363921 hasRelatedWork W2025152579 @default.

• next