FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111366068> ?p ?o ?g. }

• W2111366068 abstract "Diabetes mellitus (DM) leads to multiple complications, including severe hypoglycaemia events (SHEs). SHEs can impact a patient's quality of life and compliance and may directly result in additional costs to the health care system. The aim of this review was to evaluate the risk of severe hypoglycaemia in patients with type 1 (T1) and 2 (T2) DM as observed in everyday clinical practice for various drug regimens.We conducted a systematic review of observational (retrospective or prospective) studies in the MEDLINE, Embase, and Cochrane Library databases that covered at least 100 children or adults with T1/T2 DM. In T1 DM, basal-bolus/pre-mix insulin (human or analogue) and insulin pump were reviewed, and in T2 DM, basal-bolus/pre-mix insulin (human or analogue), oral antidiabetic drugs supported with basal insulin (human or analogue), sulfonylureas in monotherapy, and combined oral treatment were reviewed. In order to estimate SHE rates, we extracted data on the time horizon of the study, number of patients, number of SHEs, and number of patients experiencing at least one SHE. We used a random effects model to estimate the annual SHE rate. We considered the risk for other antidiabetic medications in T2 DM to be negligible and the results of our main review yielded no observational data for premixes in T1 DM so they were assessed based on relative rates taken from additional systematic reviews. The study, being a desk research, did not involve any human subjects (including human material or human data) and no ethical committee approval was asked for. For the same reason there was no need to collect informed consent for participation in the study.We identified 76 observational studies encompassing 707,722.30 patient-years. The estimated annual SHE rate varied from 0.168 (95 % CI 0.123-0.237) for insulin pump up to 1.628 for biphasic human insulin in T1 DM patients, and from 0.0035 for oral antidiabetic drugs up to 0.554 (95 % CI 0.157-7.534) for basal-bolus with human insulin in T2 DM patients.Our review indicates that SHE rates differ between patients depending on treatment regimen. However, SHEs are also driven by other factors. Proper modelling techniques are needed to use various types of information in published studies." @default.
• W2111366068 created "2016-06-24" @default.
• W2111366068 creator A5004006706 @default.
• W2111366068 creator A5004705201 @default.
• W2111366068 creator A5015781187 @default.
• W2111366068 creator A5028564988 @default.
• W2111366068 creator A5068277876 @default.
• W2111366068 creator A5083017620 @default.
• W2111366068 date "2015-10-12" @default.
• W2111366068 modified "2023-09-27" @default.
• W2111366068 title "Drug-related risk of severe hypoglycaemia in observational studies: a systematic review and meta-analysis" @default.
• W2111366068 cites W133901992 @default.
• W2111366068 cites W1489323167 @default.
• W2111366068 cites W1512877138 @default.
• W2111366068 cites W1524498402 @default.
• W2111366068 cites W1587185600 @default.
• W2111366068 cites W1591511486 @default.
• W2111366068 cites W1592847003 @default.
• W2111366068 cites W1595280126 @default.
• W2111366068 cites W1596270767 @default.
• W2111366068 cites W1647870019 @default.
• W2111366068 cites W1652735301 @default.
• W2111366068 cites W1726816406 @default.
• W2111366068 cites W1811210685 @default.
• W2111366068 cites W1840168355 @default.
• W2111366068 cites W1887734280 @default.
• W2111366068 cites W1913239326 @default.
• W2111366068 cites W1916480346 @default.
• W2111366068 cites W1924250330 @default.
• W2111366068 cites W1937299014 @default.
• W2111366068 cites W1940446787 @default.
• W2111366068 cites W1966126178 @default.
• W2111366068 cites W1968406323 @default.
• W2111366068 cites W1968864875 @default.
• W2111366068 cites W1969142376 @default.
• W2111366068 cites W1971423141 @default.
• W2111366068 cites W1974764397 @default.
• W2111366068 cites W1976457244 @default.
• W2111366068 cites W1978357328 @default.
• W2111366068 cites W1980681721 @default.
• W2111366068 cites W1981501248 @default.
• W2111366068 cites W1981978041 @default.
• W2111366068 cites W1983647289 @default.
• W2111366068 cites W1984430136 @default.
• W2111366068 cites W1984473938 @default.
• W2111366068 cites W1984606882 @default.
• W2111366068 cites W1987714540 @default.
• W2111366068 cites W1988297670 @default.
• W2111366068 cites W1990858147 @default.
• W2111366068 cites W1991200618 @default.
• W2111366068 cites W1991638285 @default.
• W2111366068 cites W1991747678 @default.
• W2111366068 cites W1997962812 @default.
• W2111366068 cites W1999395175 @default.
• W2111366068 cites W2001082310 @default.
• W2111366068 cites W2002666965 @default.
• W2111366068 cites W2003739018 @default.
• W2111366068 cites W2005935820 @default.
• W2111366068 cites W2006180168 @default.
• W2111366068 cites W2006763416 @default.
• W2111366068 cites W2007030543 @default.
• W2111366068 cites W2007262124 @default.
• W2111366068 cites W2007625375 @default.
• W2111366068 cites W2010512170 @default.
• W2111366068 cites W2012125528 @default.
• W2111366068 cites W2014514328 @default.
• W2111366068 cites W2016543357 @default.
• W2111366068 cites W2017863432 @default.
• W2111366068 cites W2020267609 @default.
• W2111366068 cites W2020292843 @default.
• W2111366068 cites W2021768264 @default.
• W2111366068 cites W2024421889 @default.
• W2111366068 cites W2027358401 @default.
• W2111366068 cites W2028451408 @default.
• W2111366068 cites W2028559423 @default.
• W2111366068 cites W2029039352 @default.
• W2111366068 cites W2030703676 @default.
• W2111366068 cites W2031432201 @default.
• W2111366068 cites W2032115155 @default.
• W2111366068 cites W2033232919 @default.
• W2111366068 cites W2034547603 @default.
• W2111366068 cites W2038808621 @default.
• W2111366068 cites W2040692717 @default.
• W2111366068 cites W2041216910 @default.
• W2111366068 cites W2041625791 @default.
• W2111366068 cites W2043096955 @default.
• W2111366068 cites W2047434834 @default.
• W2111366068 cites W2051668340 @default.
• W2111366068 cites W2052166616 @default.
• W2111366068 cites W2052404210 @default.
• W2111366068 cites W2052882373 @default.
• W2111366068 cites W2053071191 @default.
• W2111366068 cites W2054992686 @default.
• W2111366068 cites W2055159799 @default.
• W2111366068 cites W2055977062 @default.
• W2111366068 cites W2056037891 @default.
• W2111366068 cites W2057303395 @default.
• W2111366068 cites W2057771787 @default.
• W2111366068 cites W2058323732 @default.
• W2111366068 cites W2065145901 @default.

• next