FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111397963> ?p ?o ?g. }

• W2111397963 endingPage "2265" @default.
• W2111397963 startingPage "2254" @default.
• W2111397963 abstract "To increase the supply, many countries harvest allograft valves from explanted hearts of transplant recipients with ischaemic (ICM) or dilated cardiomyopathy (DCM). This study determines the structural integrity of valves from cardiomyopathic hearts.Extracellular matrix (ECM) was examined in human valves obtained from normal, ICM, and DCM hearts. To confirm if ECM changes were directly related to the cardiomyopathy, we developed a porcine model of chronic ICM. Histology and immunohistostaining, as well as non-invasive multiphoton and second harmonic generation (SHG) imaging revealed marked disruption of ECM structures in human valves from ICM and DCM hearts. The ECM was unaffected in valves from normal and acute ICM pigs, whereas chronic ICM specimens showed ECM alterations similar to those seen in ICM and DCM patients. Proteins and proteinases implicated in ECM remodelling, including Tenascin C, TGFbeta1, Cathepsin B, MMP2, were upregulated in human ICM and DCM, and porcine chronic ICM specimens.Valves from cardiomyopathic hearts showed significant ECM deterioration with a disrupted collagen and elastic fibre network. It will be important to determine the impact of this ECM damage on valve durability and calcification in vivo if allografts are to be used from these donors." @default.
• W2111397963 created "2016-06-24" @default.
• W2111397963 creator A5007642190 @default.
• W2111397963 creator A5007977210 @default.
• W2111397963 creator A5009922598 @default.
• W2111397963 creator A5013425593 @default.
• W2111397963 creator A5017075945 @default.
• W2111397963 creator A5030389428 @default.
• W2111397963 creator A5030966202 @default.
• W2111397963 creator A5057556187 @default.
• W2111397963 creator A5062174320 @default.
• W2111397963 creator A5067098527 @default.
• W2111397963 creator A5070974564 @default.
• W2111397963 date "2009-06-27" @default.
• W2111397963 modified "2023-09-23" @default.
• W2111397963 title "Cardiomyopathy is associated with structural remodelling of heart valve extracellular matrix" @default.
• W2111397963 cites W1484185611 @default.
• W2111397963 cites W1970564951 @default.
• W2111397963 cites W1972563175 @default.
• W2111397963 cites W1974538559 @default.
• W2111397963 cites W1983967850 @default.
• W2111397963 cites W2017989460 @default.
• W2111397963 cites W2040321633 @default.
• W2111397963 cites W2048919425 @default.
• W2111397963 cites W2048977489 @default.
• W2111397963 cites W2050898571 @default.
• W2111397963 cites W2054844811 @default.
• W2111397963 cites W2062044315 @default.
• W2111397963 cites W2067491846 @default.
• W2111397963 cites W2071238583 @default.
• W2111397963 cites W2101099914 @default.
• W2111397963 cites W2104127478 @default.
• W2111397963 cites W2142157178 @default.
• W2111397963 cites W2146635117 @default.
• W2111397963 cites W2151325926 @default.
• W2111397963 cites W2162452658 @default.
• W2111397963 cites W2165339721 @default.
• W2111397963 cites W2171785627 @default.
• W2111397963 cites W1989059197 @default.
• W2111397963 doi "https://doi.org/10.1093/eurheartj/ehp267" @default.
• W2111397963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2742784" @default.
• W2111397963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19561339" @default.
• W2111397963 hasPublicationYear "2009" @default.
• W2111397963 type Work @default.
• W2111397963 sameAs 2111397963 @default.
• W2111397963 citedByCount "49" @default.
• W2111397963 countsByYear W21113979632012 @default.
• W2111397963 countsByYear W21113979632013 @default.
• W2111397963 countsByYear W21113979632014 @default.
• W2111397963 countsByYear W21113979632015 @default.
• W2111397963 countsByYear W21113979632016 @default.
• W2111397963 countsByYear W21113979632017 @default.
• W2111397963 countsByYear W21113979632018 @default.
• W2111397963 countsByYear W21113979632019 @default.
• W2111397963 countsByYear W21113979632020 @default.
• W2111397963 countsByYear W21113979632021 @default.
• W2111397963 countsByYear W21113979632022 @default.
• W2111397963 crossrefType "journal-article" @default.
• W2111397963 hasAuthorship W2111397963A5007642190 @default.
• W2111397963 hasAuthorship W2111397963A5007977210 @default.
• W2111397963 hasAuthorship W2111397963A5009922598 @default.
• W2111397963 hasAuthorship W2111397963A5013425593 @default.
• W2111397963 hasAuthorship W2111397963A5017075945 @default.
• W2111397963 hasAuthorship W2111397963A5030389428 @default.
• W2111397963 hasAuthorship W2111397963A5030966202 @default.
• W2111397963 hasAuthorship W2111397963A5057556187 @default.
• W2111397963 hasAuthorship W2111397963A5062174320 @default.
• W2111397963 hasAuthorship W2111397963A5067098527 @default.
• W2111397963 hasAuthorship W2111397963A5070974564 @default.
• W2111397963 hasBestOaLocation W21113979631 @default.
• W2111397963 hasConcept C117961784 @default.
• W2111397963 hasConcept C126322002 @default.
• W2111397963 hasConcept C142724271 @default.
• W2111397963 hasConcept C164705383 @default.
• W2111397963 hasConcept C189165786 @default.
• W2111397963 hasConcept C2775932942 @default.
• W2111397963 hasConcept C2776383484 @default.
• W2111397963 hasConcept C2777738151 @default.
• W2111397963 hasConcept C2778198053 @default.
• W2111397963 hasConcept C2778797674 @default.
• W2111397963 hasConcept C2779869378 @default.
• W2111397963 hasConcept C2780309369 @default.
• W2111397963 hasConcept C71924100 @default.
• W2111397963 hasConcept C78085059 @default.
• W2111397963 hasConcept C86492073 @default.
• W2111397963 hasConcept C86803240 @default.
• W2111397963 hasConcept C95444343 @default.
• W2111397963 hasConceptScore W2111397963C117961784 @default.
• W2111397963 hasConceptScore W2111397963C126322002 @default.
• W2111397963 hasConceptScore W2111397963C142724271 @default.
• W2111397963 hasConceptScore W2111397963C164705383 @default.
• W2111397963 hasConceptScore W2111397963C189165786 @default.
• W2111397963 hasConceptScore W2111397963C2775932942 @default.
• W2111397963 hasConceptScore W2111397963C2776383484 @default.
• W2111397963 hasConceptScore W2111397963C2777738151 @default.
• W2111397963 hasConceptScore W2111397963C2778198053 @default.
• W2111397963 hasConceptScore W2111397963C2778797674 @default.
• W2111397963 hasConceptScore W2111397963C2779869378 @default.

• next