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- W2111414830 abstract "The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to AIDS research; existing models generally employ simian viruses that are divergent from HIV-1, reducing their usefulness in preclinical investigations. Based on an understanding of species-specific variation in primate TRIM5 and APOBEC3 antiretroviral genes, we constructed simian-tropic (st)HIV-1 strains that differ from HIV-1 only in the vif gene. We demonstrate that such minimally modified stHIV-1 strains are capable of high levels of replication in vitro in pig-tailed macaque (Macaca nemestrina) lymphocytes. Importantly, infection of pig-tailed macaques with stHIV-1 results in acute viremia, approaching the levels observed in HIV-1-infected humans, and an ensuing persistent infection for several months. stHIV-1 replication was controlled thereafter, at least in part, by CD8+ T cells. We demonstrate the potential utility of this HIV-1-based animal model in a chemoprophylaxis experiment, by showing that a commonly used HIV-1 therapeutic regimen can provide apparently sterilizing protection from infection following a rigorous high-dose stHIV-1 challenge." @default.
- W2111414830 created "2016-06-24" @default.
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- W2111414830 date "2009-03-17" @default.
- W2111414830 modified "2023-10-12" @default.
- W2111414830 title "A macaque model of HIV-1 infection" @default.
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- W2111414830 doi "https://doi.org/10.1073/pnas.0812587106" @default.
- W2111414830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2657417" @default.
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- W2111414830 hasPublicationYear "2009" @default.
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