FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111420593> ?p ?o ?g. }

• W2111420593 endingPage "1004" @default.
• W2111420593 startingPage "996" @default.
• W2111420593 abstract "ABSTRACT Several cyclopentane inhibitors of influenza virus neuraminidase that have inhibitory activities in tissue culture similar to those of zanamivir and oseltamivir have recently been described. These new inhibitors have been examined for efficacy against a virulent H3N2 influenza virus when administered orally to infected ferrets. Preliminary studies indicated that oral administration of BCX-1923, BCX-1827, or BCX-1812 (RWJ-270201) at a dose of 5 or 25 mg/kg of body weight was active in ferrets in reducing respiratory and constitutional signs and symptoms, but these antivirals affected virus titers in the upper and lower respiratory tracts only marginally. Of the three compounds, BCX-1812 seemed to be the most efficacious and was examined further at higher doses of 30 and 100 mg/kg. These doses significantly reduced peak virus titers in nasal washes and total virus shedding as measured by areas under the curve. Virus titers in lung homogenates were also reduced compared to those in controls, but the difference was not statistically significant. As was observed with BCX-1812 at lower doses, the nasal inflammatory cellular response, fever, and nasal signs were reduced while ferret activity was not, with activity remaining similar to uninfected animals." @default.
• W2111420593 created "2016-06-24" @default.
• W2111420593 creator A5016732690 @default.
• W2111420593 creator A5022556893 @default.
• W2111420593 creator A5023111405 @default.
• W2111420593 creator A5034812515 @default.
• W2111420593 creator A5038008011 @default.
• W2111420593 creator A5042802413 @default.
• W2111420593 creator A5059157933 @default.
• W2111420593 creator A5080405524 @default.
• W2111420593 creator A5087528863 @default.
• W2111420593 date "2002-04-01" @default.
• W2111420593 modified "2023-09-24" @default.
• W2111420593 title "Oral Administration of Cyclopentane Neuraminidase Inhibitors Protects Ferrets against Influenza Virus Infection" @default.
• W2111420593 cites W1784292360 @default.
• W2111420593 cites W1896494894 @default.
• W2111420593 cites W1977240704 @default.
• W2111420593 cites W1990184373 @default.
• W2111420593 cites W1990881499 @default.
• W2111420593 cites W2002496335 @default.
• W2111420593 cites W2003926950 @default.
• W2111420593 cites W2004554957 @default.
• W2111420593 cites W2005403524 @default.
• W2111420593 cites W2012051375 @default.
• W2111420593 cites W2016267413 @default.
• W2111420593 cites W2020755531 @default.
• W2111420593 cites W2047400336 @default.
• W2111420593 cites W2059973370 @default.
• W2111420593 cites W2066429701 @default.
• W2111420593 cites W2080385821 @default.
• W2111420593 cites W2082424272 @default.
• W2111420593 cites W2084334264 @default.
• W2111420593 cites W2086358466 @default.
• W2111420593 cites W2095804377 @default.
• W2111420593 cites W2101352601 @default.
• W2111420593 cites W2105702436 @default.
• W2111420593 cites W2113619184 @default.
• W2111420593 cites W2126383827 @default.
• W2111420593 cites W2132657130 @default.
• W2111420593 cites W2136685402 @default.
• W2111420593 cites W2151174475 @default.
• W2111420593 cites W2151763773 @default.
• W2111420593 cites W2316205659 @default.
• W2111420593 cites W2336492800 @default.
• W2111420593 doi "https://doi.org/10.1128/aac.46.4.996-1004.2002" @default.
• W2111420593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/127099" @default.
• W2111420593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11897581" @default.
• W2111420593 hasPublicationYear "2002" @default.
• W2111420593 type Work @default.
• W2111420593 sameAs 2111420593 @default.
• W2111420593 citedByCount "37" @default.
• W2111420593 countsByYear W21114205932012 @default.
• W2111420593 countsByYear W21114205932013 @default.
• W2111420593 countsByYear W21114205932014 @default.
• W2111420593 countsByYear W21114205932015 @default.
• W2111420593 countsByYear W21114205932016 @default.
• W2111420593 countsByYear W21114205932017 @default.
• W2111420593 countsByYear W21114205932018 @default.
• W2111420593 countsByYear W21114205932020 @default.
• W2111420593 countsByYear W21114205932022 @default.
• W2111420593 crossrefType "journal-article" @default.
• W2111420593 hasAuthorship W2111420593A5016732690 @default.
• W2111420593 hasAuthorship W2111420593A5022556893 @default.
• W2111420593 hasAuthorship W2111420593A5023111405 @default.
• W2111420593 hasAuthorship W2111420593A5034812515 @default.
• W2111420593 hasAuthorship W2111420593A5038008011 @default.
• W2111420593 hasAuthorship W2111420593A5042802413 @default.
• W2111420593 hasAuthorship W2111420593A5059157933 @default.
• W2111420593 hasAuthorship W2111420593A5080405524 @default.
• W2111420593 hasAuthorship W2111420593A5087528863 @default.
• W2111420593 hasBestOaLocation W21114205931 @default.
• W2111420593 hasConcept C126322002 @default.
• W2111420593 hasConcept C12914427 @default.
• W2111420593 hasConcept C134164806 @default.
• W2111420593 hasConcept C159047783 @default.
• W2111420593 hasConcept C2522874641 @default.
• W2111420593 hasConcept C2777056448 @default.
• W2111420593 hasConcept C2777538117 @default.
• W2111420593 hasConcept C2777546802 @default.
• W2111420593 hasConcept C2779134260 @default.
• W2111420593 hasConcept C2780374985 @default.
• W2111420593 hasConcept C2781416681 @default.
• W2111420593 hasConcept C2781442963 @default.
• W2111420593 hasConcept C3008058167 @default.
• W2111420593 hasConcept C32611913 @default.
• W2111420593 hasConcept C524204448 @default.
• W2111420593 hasConcept C534529494 @default.
• W2111420593 hasConcept C71924100 @default.
• W2111420593 hasConcept C86803240 @default.
• W2111420593 hasConcept C89423630 @default.
• W2111420593 hasConcept C98274493 @default.
• W2111420593 hasConceptScore W2111420593C126322002 @default.
• W2111420593 hasConceptScore W2111420593C12914427 @default.
• W2111420593 hasConceptScore W2111420593C134164806 @default.
• W2111420593 hasConceptScore W2111420593C159047783 @default.
• W2111420593 hasConceptScore W2111420593C2522874641 @default.
• W2111420593 hasConceptScore W2111420593C2777056448 @default.
• W2111420593 hasConceptScore W2111420593C2777538117 @default.

• next