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- W2111428445 abstract "Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines and type I interferons, respectively. How TLR4 coordinates the activation of these two pathways is unknown. Here we show that TLR4 activated these two signaling pathways sequentially in a process organized around endocytosis of the TLR4 complex. We propose that TLR4 first induces TIRAP-MyD88 signaling at the plasma membrane and is then endocytosed and activates TRAM-TRIF signaling from early endosomes. Our data emphasize a unifying theme in innate immune recognition whereby all type I interferon–inducing receptors signal from an intracellular location." @default.
- W2111428445 created "2016-06-24" @default.
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- W2111428445 date "2008-02-24" @default.
- W2111428445 modified "2023-10-17" @default.
- W2111428445 title "TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β" @default.
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- W2111428445 doi "https://doi.org/10.1038/ni1569" @default.
- W2111428445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4112825" @default.
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- W2111428445 hasPublicationYear "2008" @default.
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