FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111439245> ?p ?o ?g. }

• W2111439245 endingPage "5053" @default.
• W2111439245 startingPage "5044" @default.
• W2111439245 abstract "Human sensory neuron-specific G-protein-coupled receptors (SNSRs) are expressed solely in small diameter primary sensory neurons. This restricted expression pattern is of considerable therapeutic interest because small nociceptors transmit chronic pain messages. The neuronal function of human SNSRs is difficult to assess because rodent orthologs have yet to be clearly defined, and individual isoforms are found only in a small subset of primary sensory neurons. To circumvent this problem, we expressed human SNSR4 (hSNSR4; also known as Hs.mrgX1 ) in rat superior cervical ganglion (SCG), dorsal root ganglion (DRG), and hippocampal neurons using nuclear injection or recombinant adenoviruses and examined modulation of ion channels and neurotransmission using whole-cell patch-clamp techniques. BAM8-22 (a 15 amino acid C-terminal fragment of bovine adrenal medulla peptide 22), a peptide agonist derived from proenkephalin, inhibited high (but not low) voltage-activated Ca 2+ current in both DRG and SCG neurons expressing hSNSR4, whereas no response was detected in control neurons. The Ca 2+ current inhibition was concentration dependent and partially sensitive to Pertussis toxin (PTX) treatment. Additionally, the peptide was highly effective in modulating current arising from M-type K + channels in SCG neurons expressing hSNSR4. In hippocampal neurons expressing hSNSR4, BAM8-22 induced presynaptic inhibition of transmission that was abolished after PTX treatment. Our data indicate that hSNSR4, when heterologously expressed in rat neurons, can be activated by an opioid-related peptide, couples to G q/11 -proteins as well as PTX-sensitive G i/o -proteins, and modulates neuronal Ca 2+ channels, K + channels, and synaptic transmission." @default.
• W2111439245 created "2016-06-24" @default.
• W2111439245 creator A5002238604 @default.
• W2111439245 creator A5076023837 @default.
• W2111439245 date "2004-05-26" @default.
• W2111439245 modified "2023-10-17" @default.
• W2111439245 title "Modulation of Ion Channels and Synaptic Transmission by a Human Sensory Neuron-Specific G-Protein-Coupled Receptor, SNSR4/<i>mrgX1</i>, Heterologously Expressed in Cultured Rat Neurons" @default.
• W2111439245 cites W1535117441 @default.
• W2111439245 cites W1672275028 @default.
• W2111439245 cites W1799107001 @default.
• W2111439245 cites W1883044208 @default.
• W2111439245 cites W1958742527 @default.
• W2111439245 cites W1972211504 @default.
• W2111439245 cites W1983423336 @default.
• W2111439245 cites W1986027512 @default.
• W2111439245 cites W1995705528 @default.
• W2111439245 cites W1997511216 @default.
• W2111439245 cites W2003218087 @default.
• W2111439245 cites W2009667219 @default.
• W2111439245 cites W2015426350 @default.
• W2111439245 cites W2020098765 @default.
• W2111439245 cites W2022103979 @default.
• W2111439245 cites W2023724239 @default.
• W2111439245 cites W2035198661 @default.
• W2111439245 cites W2040009964 @default.
• W2111439245 cites W2042526378 @default.
• W2111439245 cites W2043534567 @default.
• W2111439245 cites W2045716874 @default.
• W2111439245 cites W2048894410 @default.
• W2111439245 cites W2050948927 @default.
• W2111439245 cites W2058426472 @default.
• W2111439245 cites W2059690890 @default.
• W2111439245 cites W2064748241 @default.
• W2111439245 cites W2068116440 @default.
• W2111439245 cites W2076324460 @default.
• W2111439245 cites W2078316320 @default.
• W2111439245 cites W2079212189 @default.
• W2111439245 cites W2083566192 @default.
• W2111439245 cites W2088700210 @default.
• W2111439245 cites W2090905251 @default.
• W2111439245 cites W2094766550 @default.
• W2111439245 cites W2102268999 @default.
• W2111439245 cites W2112927743 @default.
• W2111439245 cites W2117018607 @default.
• W2111439245 cites W2118866905 @default.
• W2111439245 cites W2118970449 @default.
• W2111439245 cites W2121367388 @default.
• W2111439245 cites W2123046464 @default.
• W2111439245 cites W2129219475 @default.
• W2111439245 cites W2144728851 @default.
• W2111439245 cites W2159306504 @default.
• W2111439245 cites W2171553829 @default.
• W2111439245 cites W2417987987 @default.
• W2111439245 cites W2433413845 @default.
• W2111439245 cites W2752832232 @default.
• W2111439245 cites W2913636289 @default.
• W2111439245 cites W4253422011 @default.
• W2111439245 cites W4318355239 @default.
• W2111439245 doi "https://doi.org/10.1523/jneurosci.0990-04.2004" @default.
• W2111439245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729361" @default.
• W2111439245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15163697" @default.
• W2111439245 hasPublicationYear "2004" @default.
• W2111439245 type Work @default.
• W2111439245 sameAs 2111439245 @default.
• W2111439245 citedByCount "62" @default.
• W2111439245 countsByYear W21114392452012 @default.
• W2111439245 countsByYear W21114392452013 @default.
• W2111439245 countsByYear W21114392452014 @default.
• W2111439245 countsByYear W21114392452015 @default.
• W2111439245 countsByYear W21114392452016 @default.
• W2111439245 countsByYear W21114392452017 @default.
• W2111439245 countsByYear W21114392452018 @default.
• W2111439245 countsByYear W21114392452019 @default.
• W2111439245 countsByYear W21114392452020 @default.
• W2111439245 countsByYear W21114392452021 @default.
• W2111439245 countsByYear W21114392452022 @default.
• W2111439245 crossrefType "journal-article" @default.
• W2111439245 hasAuthorship W2111439245A5002238604 @default.
• W2111439245 hasAuthorship W2111439245A5076023837 @default.
• W2111439245 hasBestOaLocation W21114392451 @default.
• W2111439245 hasConcept C134018914 @default.
• W2111439245 hasConcept C147944092 @default.
• W2111439245 hasConcept C148762608 @default.
• W2111439245 hasConcept C169760540 @default.
• W2111439245 hasConcept C170493617 @default.
• W2111439245 hasConcept C185263204 @default.
• W2111439245 hasConcept C185592680 @default.
• W2111439245 hasConcept C200170125 @default.
• W2111439245 hasConcept C2775908076 @default.
• W2111439245 hasConcept C2776281502 @default.
• W2111439245 hasConcept C2778794669 @default.
• W2111439245 hasConcept C2778938600 @default.
• W2111439245 hasConcept C2778993773 @default.
• W2111439245 hasConcept C49773422 @default.
• W2111439245 hasConcept C50254741 @default.
• W2111439245 hasConcept C55493867 @default.
• W2111439245 hasConcept C62478195 @default.
• W2111439245 hasConcept C80631254 @default.

• next