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- W2111440282 abstract "Patients with early stage non-small cell lung cancer (NSCLC) who are unable to tolerate lobectomy may be candidates for sub-lobar resection with brachytherapy (SLR-B) or stereotactic body radiation therapy (SBRT). The superiority of either approach has not been confirmed. This IRB-approved retrospective study compares the overall survival of contemporaneous cohorts of patients receiving either SLR-B or SBRT. The study subjects had clinical stage I NSCLC based on PET-CT staging and were considered ineligible for lobectomy. From 2006 through 2011, 56 underwent SLR-B and 47 underwent stereotactic body radiation therapy. The brachytherapy implants consisted of customized absorbable polyglactin knitted mesh containing a median of 40 (30-50) Iodine-125 seeds with a median seed activity of 0.536 mCi and total median implant activity of 21.44 mCi. The stereotactic body radiation therapy patients underwent 4-dimensional CT image planning and treatment using 3 or 5 fractions to 54 or 50 Gy. The median tumor sizes were 1.6 cm and 2.0 cm in the SLR-B and SBRT groups, respectively. The median follow-up is 32 months. At 3 years the Kaplan-Meier actuarial overall survivals are 71% and 61% in the SLR-B and SBRT groups, respectively (p = 0.3). SLR-B and SBRT appear to provide acceptable survival outcomes. This retrospective study hints at a potential superior survival with SLR-B over SBRT, which would require a larger sample size to confirm. Our study supports the importance of enrollment to RTOG 1021 prospectively comparing these techniques." @default.
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- W2111440282 date "2013-10-01" @default.
- W2111440282 modified "2023-09-25" @default.
- W2111440282 title "An Overall Survival Comparison of Sub-Lobar Resection With Brachytherapy Versus Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer" @default.
- W2111440282 doi "https://doi.org/10.1016/j.ijrobp.2013.06.1438" @default.
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