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- W2111441093 abstract "The key step in bacterial promoter opening is recognition of the -10 promoter element (T(-12)A(-11)T(-10)A(-9)A(-8)T(-7) consensus sequence) by the RNA polymerase σ subunit. We determined crystal structures of σ domain 2 bound to single-stranded DNA bearing-10 element sequences. Extensive interactions occur between the protein and the DNA backbone of every -10 element nucleotide. Base-specific interactions occur primarily with A(-11) and T(-7), which are flipped out of the single-stranded DNA base stack and buried deep in protein pockets. The structures, along with biochemical data, support a model where the recognition of the -10 element sequence drives initial promoter opening as the bases of the nontemplate strand are extruded from the DNA double-helix and captured by σ. These results provide a detailed structural basis for the critical roles of A(-11) and T(-7) in promoter melting and reveal important insights into the initiation of transcription bubble formation." @default.
- W2111441093 created "2016-06-24" @default.
- W2111441093 creator A5015912858 @default.
- W2111441093 creator A5069772661 @default.
- W2111441093 date "2011-12-01" @default.
- W2111441093 modified "2023-10-14" @default.
- W2111441093 title "Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit" @default.
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- W2111441093 doi "https://doi.org/10.1016/j.cell.2011.10.041" @default.
- W2111441093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3245737" @default.
- W2111441093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22136875" @default.
- W2111441093 hasPublicationYear "2011" @default.
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