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• W2111446319 endingPage "10765" @default.
• W2111446319 startingPage "10756" @default.
• W2111446319 abstract "ABSTRACT The neurotrophin receptor (p75NTR) serves as a receptor for rabies virus (RV). We expressed and purified a soluble chimera consisting of the p75NTR ectodomain fused to the human immunoglobulin G1 (IgG1) Fc fragment (p75-Fc). Although p75-Fc interacts with RV, the infectivity of RV did not decrease significantly when it was incubated in the presence of the soluble receptor alone. However, when it was subsequently incubated with an antihuman IgG directed against the Fc fragment of p75-Fc, the infectivity of RV was significantly lowered (>90%), whereas incubation with antihuman IgG alone had no effect. We then selected eight independent RV mutants that were not neutralized by p75-Fc and antihuman IgG ( srr [soluble receptor resistant] mutants). Each mutant carried a single mutation in the glycoprotein gene leading to one amino acid substitution in the protein. A total of four different substitutions were found. Two of the mutations were located at position 318 (phenylalanine replaced by a serine or a valine residue), and two were located at position 352 (histidine replaced by a tyrosine or an arginine residue). All of the mutations prevented the interaction with p75NTR as either a soluble or a membrane-anchored form. Two mutants (F318S) and (H352R) resulted in the formation of small plaques on BSR cells, probably due to the slower maturation of the glycoprotein. Immunoprecipitation, immunofluorescence, and neutralization assays showed that the four mutated glycoproteins still interacted with representative anti-RV glycoprotein monoclonal antibodies (MAbs), indicating that p75NTR binds outside of the known RV glycoprotein antigenic sites." @default.
• W2111446319 created "2016-06-24" @default.
• W2111446319 creator A5084267146 @default.
• W2111446319 creator A5088564920 @default.
• W2111446319 date "2002-11-01" @default.
• W2111446319 modified "2023-10-13" @default.
• W2111446319 title "Mutations Conferring Resistance to Neutralization by a Soluble Form of the Neurotrophin Receptor (p75NTR) Map outside of the Known Antigenic Sites of the Rabies Virus Glycoprotein" @default.
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• W2111446319 doi "https://doi.org/10.1128/jvi.76.21.10756-10765.2002" @default.
• W2111446319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136618" @default.
• W2111446319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12368318" @default.
• W2111446319 hasPublicationYear "2002" @default.
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