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- W2111449500 abstract "AbstractThe influence of amphotericin B on PAH transport as well as on lipid peroxidation in rat renal cortical slices was studied in vitro and ex vivo. In vitro, renal cortical slices were incubated with different amphotericin B (AmB) concentrations (2-60 μg/mL) or with the corresponding vehicle concentrations of sodium deoxycholate (NaDo) (1.64-49.2 μg/mL) and time dependency (15-30-60 min) with 30 μg/mL AmB or 24.6 μg/mL NaDo. Ex vivo, PAH transport of renal cortical slices was investigated following a 3-day intravenous AmB administration with 3 mg/kg per day or 2.46 mg/kg/day NaDo, respectively. In vitro AmB as well as NaDo decreased PAH transport dose and time dependency. At the highest AmB concentration of 60 μg/mL, PAH uptake decreased to 17.6%. The corresponding NaDo concentration (49.2 μg/mL) decreased PAH uptake to 33.3%. Time dependently AmB decreased PAH uptake to 25% after 60 min, NaDo caused a decrease to 69%. Administration of AmB for 3 days resulted in a PAH decline to 81%; NaDo decreased PAH uptake to 77%. In vitro as well as in vivo, AmB or its vehicle did not induce lipid peroxidation in renal cortical tissue. In summary, the results show that AmB and its vehicle, NaDo, decrease PAH uptake by renal cortical cells, reflecting a direct effect of AmB on tubular function. The impairment of the PAH transport is not due to enhanced lipid peroxidation.Key Words: p-Aminohippurate transportAmphotericin BLipid peroxidationSodium deoxycholate" @default.
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- W2111449500 title "Amphotericin B and Sodium Deoxycholate Induced Impairment of Renal p-Aminohippurate Accumulation (PAH) and Effect on Lipid Peroxidation in the Rat Kidney" @default.
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- W2111449500 doi "https://doi.org/10.3109/08860229209039112" @default.
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