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- W2111461823 endingPage "287" @default.
- W2111461823 startingPage "259" @default.
- W2111461823 abstract "Proteins belonging to the XPF/MUS81 family play important roles in the repair of DNA lesions caused by UV-light or DNA cross-linking agents. Most eukaryotes have four family members that assemble into two distinct heterodimeric complexes, XPF-ERCC1 and MUS81-EME1. Each complex contains one catalytic and one noncatalytic subunit and exhibits endonuclease activity with a variety of 3'-flap or fork DNA structures. The catalytic subunits share a characteristic core containing an excision repair cross complementation group 4 (ERCC4) nuclease domain and a tandem helix-hairpin-helix (HhH)(2) domain. Diverged domains are present in the noncatalytic subunits and may be required for substrate targeting. Vertebrates possess two additional family members, FANCM and Fanconi anemia-associated protein 24 kDa (FAAP24), which possess inactive nuclease domains. Instead, FANCM contains a functional Superfamily 2 (SF2) helicase domain that is required for DNA translocation. Determining how these enzymes recognize specific DNA substrates and promote key repair reactions is an important challenge for the future." @default.
- W2111461823 created "2016-06-24" @default.
- W2111461823 creator A5015511982 @default.
- W2111461823 creator A5024098581 @default.
- W2111461823 creator A5054117046 @default.
- W2111461823 date "2008-06-01" @default.
- W2111461823 modified "2023-10-10" @default.
- W2111461823 title "Structural and Functional Relationships of the XPF/MUS81 Family of Proteins" @default.
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