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• W2111465295 abstract "A whole-cell mediated asymmetric reduction of oxcarbazepine 1 to S-licarbazepine 2, a key intermediate in the synthesis of Eslicarbazepine acetate, was achieved using the yeast strain Pichia methanolica 103660. The reduction was carried out in a biphasic system consisting of (1 : 1) de-ionized water and hexane. This organism catalyzed the reaction to yield the S-enantiomer 2 with excellent conversion (>98%) and enantiomeric excess (ee > 98%) within 24 h of incubation." @default.
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• W2111465295 date "2012-01-01" @default.
• W2111465295 modified "2023-09-26" @default.
• W2111465295 title "Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium" @default.
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• W2111465295 doi "https://doi.org/10.1039/c2cy00537a" @default.
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