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• W2111465765 abstract "DNA methylation is an epigenetic modification involved in both normal developmental processes and disease states through the modulation of gene expression and the maintenance of genomic organization. Conventional methods of DNA methylation analysis, such as bisulfite sequencing, methylation sensitive restriction enzyme digestion and array-based detection techniques, have major limitations that impede high-throughput genome-wide analysis. We describe a novel technique, MBD-isolated Genome Sequencing (MiGS), which combines precipitation of methylated DNA by recombinant methyl-CpG binding domain of MBD2 protein and sequencing of the isolated DNA by a massively parallel sequencer. We utilized MiGS to study three isogenic cancer cell lines with varying degrees of DNA methylation. We successfully detected previously known methylated regions in these cells and identified hundreds of novel methylated regions. This technique is highly specific and sensitive and can be applied to any biological settings to identify differentially methylated regions at the genomic scale." @default.
• W2111465765 created "2016-06-24" @default.
• W2111465765 creator A5016306089 @default.
• W2111465765 creator A5038574644 @default.
• W2111465765 creator A5070471092 @default.
• W2111465765 date "2009-11-11" @default.
• W2111465765 modified "2023-10-02" @default.
• W2111465765 title "MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome" @default.
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• W2111465765 doi "https://doi.org/10.1093/nar/gkp992" @default.
• W2111465765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2811030" @default.
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• W2111465765 hasPublicationYear "2009" @default.
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