FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111483757> ?p ?o ?g. }

• W2111483757 abstract "Factor V Leiden (FVL) mutation elevates the risk of venous thromboembolism (VTE) in general. During pregnancy, the haemostatic balance is changed in the direction of hypercoagulability, resulting in an increased incidence of VTE. 42 women were followed longitudinally during pregnancy and the puerperium. Classic and modified activated protein C (APC) ratios decreased during pregnancy. However, the modified ratio was above the lower limit for non-carriers, and can be used to detect the FVL mutation during pregnancy. Increased levels of prothrombin fragment 1+2 (F1+2), soluble fibrin (SF) and D-dimer indicated activation of blood coagulation. Fibrinogen, Factor VIII and plasminogen activator inhibitor type 1 and type 2 levels increased. Free protein S and tissue plasminogen activator activity decreased. Protein C levels remained unchanged. Sonoclot analyses indicated hypercoagulability during pregnancy. The same reference Sonoclot curve can be used throughout pregnancy. 5 986 women were genotyped for the FVL mutation; the prevalence of FVL carriership was 8.1%. 500 carriers and 1 058 controls were followed longitudinally and haemostatic markers were analysed. There were no differences regarding placenta-mediated complications or gestational age at delivery. The incidences of neonatal asphyxia, eclampsia, intrauterine fetal death, intrapartum death and unexplained late miscarriage were low. The incidence of blood loss exceeding 1000 ml at delivery was lower in FVL carriers. There were three VTEs among FVL carriers and none among controls. No difference in superficial thrombophlebitis was found. Genotyping for the FVL mutation in healthy pregnant women without heredity for VTE is doubtful, nor can genotyping be justified in women with obstetric complications. F1+2 and D-dimer increased during pregnancy and levels were higher than eight weeks postpartum. Alterations in SF were minor or absent. Levels of F1+2 and SF in carriers and non-carriers were the same during pregnancy. Carriers had higher levels of D-dimer than non-carriers during both pregnancy and the puerperium. The levels of all markers were in the same ranges in women with and without complications, and were unaffected by zygosity or additional thrombophilia. F1+2, SF or D-dimer cannot serve as predictors of placenta-mediated complications or VTE in FVL carriers." @default.
• W2111483757 created "2016-06-24" @default.
• W2111483757 creator A5054430668 @default.
• W2111483757 date "2009-10-12" @default.
• W2111483757 modified "2023-09-26" @default.
• W2111483757 title "Factor V Leiden mutation and pregnancy. Haemostasis during pregnancy in non-carriers and carriers of factor V Leiden mutation, with special emphasis on placenta-mediated and venous thromboembolic complications and on blood coagulation and fibrinolysis markers for prediction of complications" @default.
• W2111483757 cites W107233682 @default.
• W2111483757 cites W108586273 @default.
• W2111483757 cites W115249879 @default.
• W2111483757 cites W125938864 @default.
• W2111483757 cites W131637596 @default.
• W2111483757 cites W1531281563 @default.
• W2111483757 cites W1568390176 @default.
• W2111483757 cites W1598710217 @default.
• W2111483757 cites W1837804097 @default.
• W2111483757 cites W1892541075 @default.
• W2111483757 cites W1901029512 @default.
• W2111483757 cites W193457800 @default.
• W2111483757 cites W193886378 @default.
• W2111483757 cites W1943918823 @default.
• W2111483757 cites W1965049388 @default.
• W2111483757 cites W1965875354 @default.
• W2111483757 cites W1965958910 @default.
• W2111483757 cites W1966929181 @default.
• W2111483757 cites W1967221315 @default.
• W2111483757 cites W1968930113 @default.
• W2111483757 cites W1969040779 @default.
• W2111483757 cites W1970295357 @default.
• W2111483757 cites W1970312914 @default.
• W2111483757 cites W1973932789 @default.
• W2111483757 cites W1975422670 @default.
• W2111483757 cites W1976250839 @default.
• W2111483757 cites W1977435299 @default.
• W2111483757 cites W1978418482 @default.
• W2111483757 cites W1982633139 @default.
• W2111483757 cites W1985480163 @default.
• W2111483757 cites W1985810811 @default.
• W2111483757 cites W1986288691 @default.
• W2111483757 cites W1986317257 @default.
• W2111483757 cites W1987344703 @default.
• W2111483757 cites W1990813612 @default.
• W2111483757 cites W1992865679 @default.
• W2111483757 cites W1995474189 @default.
• W2111483757 cites W1997529430 @default.
• W2111483757 cites W1997695705 @default.
• W2111483757 cites W1997696157 @default.
• W2111483757 cites W1998584559 @default.
• W2111483757 cites W2001910730 @default.
• W2111483757 cites W2003303599 @default.
• W2111483757 cites W2003753364 @default.
• W2111483757 cites W2004834643 @default.
• W2111483757 cites W2004860469 @default.
• W2111483757 cites W2005483219 @default.
• W2111483757 cites W2006919546 @default.
• W2111483757 cites W2007094847 @default.
• W2111483757 cites W2007632493 @default.
• W2111483757 cites W2011156647 @default.
• W2111483757 cites W2011993702 @default.
• W2111483757 cites W2016794646 @default.
• W2111483757 cites W2017392057 @default.
• W2111483757 cites W2017698690 @default.
• W2111483757 cites W2019818970 @default.
• W2111483757 cites W2022031418 @default.
• W2111483757 cites W2024761692 @default.
• W2111483757 cites W2026537521 @default.
• W2111483757 cites W2026882731 @default.
• W2111483757 cites W2032221813 @default.
• W2111483757 cites W2034688592 @default.
• W2111483757 cites W2035884990 @default.
• W2111483757 cites W2037362929 @default.
• W2111483757 cites W2044173767 @default.
• W2111483757 cites W2048266528 @default.
• W2111483757 cites W2048319059 @default.
• W2111483757 cites W2049682361 @default.
• W2111483757 cites W2051247267 @default.
• W2111483757 cites W2055695706 @default.
• W2111483757 cites W2057616710 @default.
• W2111483757 cites W2059308063 @default.
• W2111483757 cites W2062251724 @default.
• W2111483757 cites W2062411855 @default.
• W2111483757 cites W2062767666 @default.
• W2111483757 cites W2062820780 @default.
• W2111483757 cites W2066373623 @default.
• W2111483757 cites W2069053387 @default.
• W2111483757 cites W2070630424 @default.
• W2111483757 cites W2070685789 @default.
• W2111483757 cites W2070891258 @default.
• W2111483757 cites W2074140618 @default.
• W2111483757 cites W2075273329 @default.
• W2111483757 cites W2076923015 @default.
• W2111483757 cites W2077044374 @default.
• W2111483757 cites W2078141125 @default.
• W2111483757 cites W2081010891 @default.
• W2111483757 cites W2081665361 @default.
• W2111483757 cites W2083205711 @default.
• W2111483757 cites W2085107591 @default.
• W2111483757 cites W2087028916 @default.
• W2111483757 cites W2089926075 @default.
• W2111483757 cites W2092530980 @default.
• W2111483757 cites W2094585869 @default.

• next