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- W2111493170 endingPage "3856" @default.
- W2111493170 startingPage "3848" @default.
- W2111493170 abstract "ABSTRACT A cause of aging in Saccharomyces cerevisiae is the accumulation of extrachromosomal ribosomal DNA circles (ERCs). Introduction of an ERC into young mother cells shortens life span and accelerates the onset of age-associated sterility. It is important to understand the process by which ERCs are generated. Here, we demonstrate that homologous recombination is necessary for ERC formation. rad52 mutant cells, defective in DNA repair through homologous recombination, do not accumulate ERCs with age, and mutations in other genes of the RAD52 class have varying effects on ERC formation. rad52 mutation leads to a progressive delocalization of Sir3p from telomeres to other nuclear sites with age and, surprisingly, shortens life span. We speculate that spontaneous DNA damage, perhaps double-strand breaks, causes lethality in mutants of the RAD52 class and may be an initial step of aging in wild-type cells." @default.
- W2111493170 created "2016-06-24" @default.
- W2111493170 creator A5011779065 @default.
- W2111493170 creator A5013771208 @default.
- W2111493170 creator A5049978831 @default.
- W2111493170 date "1999-05-01" @default.
- W2111493170 modified "2023-10-17" @default.
- W2111493170 title "Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span in <i>Saccharomyces cerevisiae</i>" @default.
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- W2111493170 doi "https://doi.org/10.1128/mcb.19.5.3848" @default.