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• W2111509870 abstract "In mitochondria, complex I (NADH:ubiquinone oxidoreductase) uses the redox potential energy from NADH oxidation by ubiquinone to transport protons across the inner membrane, contributing to the proton-motive force. However, in some prokaryotes, complex I may transport sodium ions instead, and three subunits in the membrane domain of complex I are closely related to subunits from the Mrp family of Na(+)/H(+) antiporters. Here, we define the relationship between complex I from Bos taurus heart mitochondria, a close model for the human enzyme, and sodium ion transport across the mitochondrial inner membrane. In accord with current consensus, we exclude the possibility of redox-coupled Na(+) transport by B. taurus complex I. Instead, we show that the deactive form of complex I, which is formed spontaneously when enzyme turnover is precluded by lack of substrates, is a Na(+)/H(+) antiporter. The antiporter activity is abolished upon reactivation by the addition of substrates and by the complex I inhibitor rotenone. It is specific for Na(+) over K(+), and it is not exhibited by complex I from the yeast Yarrowia lipolytica, which thus has a less extensive deactive transition. We propose that the functional connection between the redox and transporter modules of complex I is broken in the deactive state, allowing the transport module to assert its independent properties. The deactive state of complex I is formed during hypoxia, when respiratory chain turnover is slowed, and may contribute to determining the outcome of ischemia-reperfusion injury." @default.
• W2111509870 created "2016-06-24" @default.
• W2111509870 creator A5008424837 @default.
• W2111509870 creator A5056046836 @default.
• W2111509870 date "2012-10-01" @default.
• W2111509870 modified "2023-10-12" @default.
• W2111509870 title "The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na+/H+ Antiporter" @default.
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• W2111509870 doi "https://doi.org/10.1074/jbc.m112.384560" @default.
• W2111509870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3464577" @default.
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• W2111509870 hasPublicationYear "2012" @default.
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