FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111513915> ?p ?o ?g. }

• W2111513915 endingPage "811" @default.
• W2111513915 startingPage "803" @default.
• W2111513915 abstract "<h3>Background</h3> Vascular remodelling plays a central role in asthma and chronic obstructive pulmonary disease (COPD). Bradykinin (BK) is a vasoactive proinflammatory peptide mediating acute responses in asthma. We investigated the role of angiogenic factors in relation to BK receptors in asthma and COPD. <h3>Methods</h3> Bronchial biopsies from 33 patients with COPD, 24 old (≥50 years) patients with (≥50 years) asthma, 18 old control smokers, 11 old control non-smokers, 15 young (≤40yrs) patients with (≤40 years) asthma and 10 young control non-smokers were immunostained for CD31, vascular endothelial growth factor-A (VEGF-A), angiogenin and BK receptors (B2R and B1R). Fibroblast and endothelial co-localisation of relevant molecules were performed by immunofluorescence. BK-induced VEGF-A and angiogenin release was studied (ELISA) in bronchial fibroblasts from subjects with asthma and COPD. <h3>Results</h3> In bronchial lamina propria of old patients with asthma, CD31 and VEGF-A⁺ cell numbers were higher than old control non-smokers (p<0.05). Angiogenin⁺, B2R⁺ and B1R⁺ cell numbers in old patients with asthma were higher than in old control non-smokers, control smokers and patients with COPD (p<0.01). Angiogenin⁺ cell numbers were higher in patients with COPD than both old control groups (p<0.05). In all patients with asthma the number of B2R⁺ cells was positively related to the numbers of B1R⁺ (r_s=0.43), angiogenin⁺ (r_s=0.42) and CD31 cells (r_s=0.46) (p<0.01). Angiogenin⁺ cell numbers were negatively related to forced expiratory volume in 1 s (r_s=−0.415, p=0.008). Double immunofluorescence revealed that CD31 cells of capillary vessels coexpressed B2R and that fibroblasts coexpressed B2R, VEGF-A and angiogenin. BK (10⁻⁶M) induced significant angiogenin release in fibroblasts from asthma and to a lesser extent in COPD. <h3>Conclusions</h3> Unlike COPD, this study suggests the involvement of BK receptors in bronchial vascular remodelling in asthma." @default.
• W2111513915 created "2016-06-24" @default.
• W2111513915 creator A5009310749 @default.
• W2111513915 creator A5010359057 @default.
• W2111513915 creator A5013383103 @default.
• W2111513915 creator A5018991397 @default.
• W2111513915 creator A5027765230 @default.
• W2111513915 creator A5030603878 @default.
• W2111513915 creator A5034491326 @default.
• W2111513915 creator A5037643316 @default.
• W2111513915 creator A5050285523 @default.
• W2111513915 creator A5058984480 @default.
• W2111513915 creator A5064098106 @default.
• W2111513915 creator A5071921275 @default.
• W2111513915 creator A5076444958 @default.
• W2111513915 creator A5078452083 @default.
• W2111513915 date "2013-06-05" @default.
• W2111513915 modified "2023-09-28" @default.
• W2111513915 title "Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD" @default.
• W2111513915 cites W101843882 @default.
• W2111513915 cites W1580173321 @default.
• W2111513915 cites W1869326453 @default.
• W2111513915 cites W1870141733 @default.
• W2111513915 cites W1934670864 @default.
• W2111513915 cites W1973995326 @default.
• W2111513915 cites W1984344949 @default.
• W2111513915 cites W1984614529 @default.
• W2111513915 cites W1986077570 @default.
• W2111513915 cites W1987413312 @default.
• W2111513915 cites W1992497300 @default.
• W2111513915 cites W1997384491 @default.
• W2111513915 cites W2023370394 @default.
• W2111513915 cites W2026030771 @default.
• W2111513915 cites W2027346283 @default.
• W2111513915 cites W2027742580 @default.
• W2111513915 cites W2028566456 @default.
• W2111513915 cites W2035972404 @default.
• W2111513915 cites W2061443150 @default.
• W2111513915 cites W2063924458 @default.
• W2111513915 cites W2096242114 @default.
• W2111513915 cites W2098776076 @default.
• W2111513915 cites W2108410418 @default.
• W2111513915 cites W2108877784 @default.
• W2111513915 cites W2116194406 @default.
• W2111513915 cites W2120215146 @default.
• W2111513915 cites W2124014266 @default.
• W2111513915 cites W2129119773 @default.
• W2111513915 cites W2131790007 @default.
• W2111513915 cites W2136576396 @default.
• W2111513915 cites W2160926771 @default.
• W2111513915 cites W2171089860 @default.
• W2111513915 cites W4246556938 @default.
• W2111513915 cites W4376043783 @default.
• W2111513915 doi "https://doi.org/10.1136/thoraxjnl-2012-202741" @default.
• W2111513915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23739138" @default.
• W2111513915 hasPublicationYear "2013" @default.
• W2111513915 type Work @default.
• W2111513915 sameAs 2111513915 @default.
• W2111513915 citedByCount "26" @default.
• W2111513915 countsByYear W21115139152014 @default.
• W2111513915 countsByYear W21115139152015 @default.
• W2111513915 countsByYear W21115139152016 @default.
• W2111513915 countsByYear W21115139152017 @default.
• W2111513915 countsByYear W21115139152018 @default.
• W2111513915 countsByYear W21115139152019 @default.
• W2111513915 countsByYear W21115139152020 @default.
• W2111513915 countsByYear W21115139152021 @default.
• W2111513915 countsByYear W21115139152022 @default.
• W2111513915 countsByYear W21115139152023 @default.
• W2111513915 crossrefType "journal-article" @default.
• W2111513915 hasAuthorship W2111513915A5009310749 @default.
• W2111513915 hasAuthorship W2111513915A5010359057 @default.
• W2111513915 hasAuthorship W2111513915A5013383103 @default.
• W2111513915 hasAuthorship W2111513915A5018991397 @default.
• W2111513915 hasAuthorship W2111513915A5027765230 @default.
• W2111513915 hasAuthorship W2111513915A5030603878 @default.
• W2111513915 hasAuthorship W2111513915A5034491326 @default.
• W2111513915 hasAuthorship W2111513915A5037643316 @default.
• W2111513915 hasAuthorship W2111513915A5050285523 @default.
• W2111513915 hasAuthorship W2111513915A5058984480 @default.
• W2111513915 hasAuthorship W2111513915A5064098106 @default.
• W2111513915 hasAuthorship W2111513915A5071921275 @default.
• W2111513915 hasAuthorship W2111513915A5076444958 @default.
• W2111513915 hasAuthorship W2111513915A5078452083 @default.
• W2111513915 hasBestOaLocation W21115139151 @default.
• W2111513915 hasConcept C126322002 @default.
• W2111513915 hasConcept C134018914 @default.
• W2111513915 hasConcept C142724271 @default.
• W2111513915 hasConcept C170493617 @default.
• W2111513915 hasConcept C203014093 @default.
• W2111513915 hasConcept C2776042228 @default.
• W2111513915 hasConcept C2776719180 @default.
• W2111513915 hasConcept C2776780178 @default.
• W2111513915 hasConcept C2779591629 @default.
• W2111513915 hasConcept C2780394083 @default.
• W2111513915 hasConcept C71924100 @default.
• W2111513915 hasConceptScore W2111513915C126322002 @default.
• W2111513915 hasConceptScore W2111513915C134018914 @default.

• next