Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111514882> ?p ?o ?g. }
- W2111514882 endingPage "1569" @default.
- W2111514882 startingPage "1559" @default.
- W2111514882 abstract "Abstract Type III galactosemia is a metabolic disorder caused by reduced activity of UDP-galactose-4-epimerase, which participates in galactose metabolism and the generation of various UDP-sugar species. We characterized gale-1 in Caenorhabditis elegans and found that a complete loss-of-function mutation is lethal, as has been hypothesized for humans, whereas a nonlethal partial loss-of-function allele causes a variety of developmental abnormalities, likely resulting from the impairment of the glycosylation process. We also observed that gale-1 mutants are hypersensitive to galactose as well as to infections. Interestingly, we found interactions between gale-1 and the unfolded protein response." @default.
- W2111514882 created "2016-06-24" @default.
- W2111514882 creator A5008470429 @default.
- W2111514882 creator A5051321612 @default.
- W2111514882 creator A5077357864 @default.
- W2111514882 creator A5080327174 @default.
- W2111514882 date "2014-10-08" @default.
- W2111514882 modified "2023-10-03" @default.
- W2111514882 title "Developmental Defects in a <i>Caenorhabditis elegans</i> Model for Type III Galactosemia" @default.
- W2111514882 cites W1157574667 @default.
- W2111514882 cites W1502829651 @default.
- W2111514882 cites W1541741307 @default.
- W2111514882 cites W1601078451 @default.
- W2111514882 cites W1944127002 @default.
- W2111514882 cites W1965843055 @default.
- W2111514882 cites W1967883750 @default.
- W2111514882 cites W1976730135 @default.
- W2111514882 cites W1979209047 @default.
- W2111514882 cites W1982131709 @default.
- W2111514882 cites W1983602468 @default.
- W2111514882 cites W1986737010 @default.
- W2111514882 cites W1986883777 @default.
- W2111514882 cites W1990295810 @default.
- W2111514882 cites W1992007773 @default.
- W2111514882 cites W1992241459 @default.
- W2111514882 cites W1995428749 @default.
- W2111514882 cites W1995471591 @default.
- W2111514882 cites W2002725367 @default.
- W2111514882 cites W2003619459 @default.
- W2111514882 cites W2007735611 @default.
- W2111514882 cites W2018351107 @default.
- W2111514882 cites W2018359498 @default.
- W2111514882 cites W2022323553 @default.
- W2111514882 cites W2025219025 @default.
- W2111514882 cites W2026604946 @default.
- W2111514882 cites W2026763337 @default.
- W2111514882 cites W2027920182 @default.
- W2111514882 cites W2037997375 @default.
- W2111514882 cites W2038492783 @default.
- W2111514882 cites W2041985227 @default.
- W2111514882 cites W2046386872 @default.
- W2111514882 cites W2049515194 @default.
- W2111514882 cites W2051222681 @default.
- W2111514882 cites W2051955172 @default.
- W2111514882 cites W2052125294 @default.
- W2111514882 cites W2053092498 @default.
- W2111514882 cites W2053470799 @default.
- W2111514882 cites W2057969917 @default.
- W2111514882 cites W2068023771 @default.
- W2111514882 cites W2068746109 @default.
- W2111514882 cites W2070981649 @default.
- W2111514882 cites W2076205567 @default.
- W2111514882 cites W2081731224 @default.
- W2111514882 cites W2085682996 @default.
- W2111514882 cites W2095035085 @default.
- W2111514882 cites W2100939012 @default.
- W2111514882 cites W2104374155 @default.
- W2111514882 cites W2112286580 @default.
- W2111514882 cites W2112913046 @default.
- W2111514882 cites W2116473078 @default.
- W2111514882 cites W2119629514 @default.
- W2111514882 cites W2137184821 @default.
- W2111514882 cites W2137662702 @default.
- W2111514882 cites W2140591044 @default.
- W2111514882 cites W2144059760 @default.
- W2111514882 cites W2151716132 @default.
- W2111514882 cites W2153275355 @default.
- W2111514882 cites W2155884826 @default.
- W2111514882 cites W2158538546 @default.
- W2111514882 cites W2158776686 @default.
- W2111514882 cites W2160792403 @default.
- W2111514882 cites W2163353934 @default.
- W2111514882 cites W2164390141 @default.
- W2111514882 doi "https://doi.org/10.1534/genetics.114.170084" @default.
- W2111514882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256771" @default.
- W2111514882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25298520" @default.
- W2111514882 hasPublicationYear "2014" @default.
- W2111514882 type Work @default.
- W2111514882 sameAs 2111514882 @default.
- W2111514882 citedByCount "20" @default.
- W2111514882 countsByYear W21115148822015 @default.
- W2111514882 countsByYear W21115148822016 @default.
- W2111514882 countsByYear W21115148822017 @default.
- W2111514882 countsByYear W21115148822018 @default.
- W2111514882 countsByYear W21115148822019 @default.
- W2111514882 countsByYear W21115148822020 @default.
- W2111514882 countsByYear W21115148822021 @default.
- W2111514882 countsByYear W21115148822022 @default.
- W2111514882 crossrefType "journal-article" @default.
- W2111514882 hasAuthorship W2111514882A5008470429 @default.
- W2111514882 hasAuthorship W2111514882A5051321612 @default.
- W2111514882 hasAuthorship W2111514882A5077357864 @default.
- W2111514882 hasAuthorship W2111514882A5080327174 @default.
- W2111514882 hasBestOaLocation W21115148821 @default.
- W2111514882 hasConcept C104317684 @default.
- W2111514882 hasConcept C105951970 @default.
- W2111514882 hasConcept C127716648 @default.
- W2111514882 hasConcept C14036430 @default.