Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111523114> ?p ?o ?g. }
- W2111523114 endingPage "1650" @default.
- W2111523114 startingPage "1641" @default.
- W2111523114 abstract "ABSTRACT Staphylococcus aureus is a Gram-positive pathogen that causes devastating disease and whose pathogenesis is dependent on interactions with host cell factors. Staphylococcal clumping factor A (ClfA) is a highly conserved fibrinogen (Fg)-binding protein and virulence factor that contributes to host tissue adhesion and initiation of infection. ClfA is being investigated as a possible component of a staphylococcal vaccine. We report the development of an Fg-binding assay that is specific for ClfA-mediated binding. Using the assay, we show that despite the presence of anti-ClfA antibodies, human sera from unvaccinated subjects are unable to prevent the binding of S. aureus to an Fg-coated surface. In contrast, antibodies elicited by a recombinant ClfA-containing vaccine were capable of blocking the ClfA-dependent binding of a diverse and clinically relevant collection of staphylococcal strains to Fg. These functional antibodies were also able to displace S. aureus already bound to Fg, suggesting that the ligand-binding activity of ClfA can be effectively neutralized through vaccination." @default.
- W2111523114 created "2016-06-24" @default.
- W2111523114 creator A5003248918 @default.
- W2111523114 creator A5008570645 @default.
- W2111523114 creator A5015250792 @default.
- W2111523114 creator A5015860682 @default.
- W2111523114 creator A5029504846 @default.
- W2111523114 creator A5038105367 @default.
- W2111523114 creator A5050598836 @default.
- W2111523114 creator A5053242914 @default.
- W2111523114 creator A5066245741 @default.
- W2111523114 creator A5071866103 @default.
- W2111523114 creator A5085804612 @default.
- W2111523114 creator A5086076714 @default.
- W2111523114 date "2012-10-01" @default.
- W2111523114 modified "2023-09-27" @default.
- W2111523114 title "A Recombinant Clumping Factor A-Containing Vaccine Induces Functional Antibodies to Staphylococcus aureus That Are Not Observed after Natural Exposure" @default.
- W2111523114 cites W1972560989 @default.
- W2111523114 cites W2014798328 @default.
- W2111523114 cites W2021604789 @default.
- W2111523114 cites W2023705783 @default.
- W2111523114 cites W2029900219 @default.
- W2111523114 cites W2030904449 @default.
- W2111523114 cites W2040823934 @default.
- W2111523114 cites W2048818416 @default.
- W2111523114 cites W2052620064 @default.
- W2111523114 cites W2067523074 @default.
- W2111523114 cites W2071677554 @default.
- W2111523114 cites W2073637966 @default.
- W2111523114 cites W2078504495 @default.
- W2111523114 cites W2085212468 @default.
- W2111523114 cites W2085645765 @default.
- W2111523114 cites W2088362583 @default.
- W2111523114 cites W2089957746 @default.
- W2111523114 cites W2090916943 @default.
- W2111523114 cites W2103449042 @default.
- W2111523114 cites W2106279568 @default.
- W2111523114 cites W2108023699 @default.
- W2111523114 cites W2110190915 @default.
- W2111523114 cites W2110481642 @default.
- W2111523114 cites W2115833554 @default.
- W2111523114 cites W2119011878 @default.
- W2111523114 cites W2120480555 @default.
- W2111523114 cites W2121729767 @default.
- W2111523114 cites W2145865433 @default.
- W2111523114 cites W2149824906 @default.
- W2111523114 cites W2152783224 @default.
- W2111523114 cites W2155509280 @default.
- W2111523114 cites W2162593826 @default.
- W2111523114 cites W2165139231 @default.
- W2111523114 cites W2165547120 @default.
- W2111523114 cites W2169198604 @default.
- W2111523114 cites W4232169883 @default.
- W2111523114 doi "https://doi.org/10.1128/cvi.00354-12" @default.
- W2111523114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3485874" @default.
- W2111523114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22896688" @default.
- W2111523114 hasPublicationYear "2012" @default.
- W2111523114 type Work @default.
- W2111523114 sameAs 2111523114 @default.
- W2111523114 citedByCount "51" @default.
- W2111523114 countsByYear W21115231142012 @default.
- W2111523114 countsByYear W21115231142013 @default.
- W2111523114 countsByYear W21115231142014 @default.
- W2111523114 countsByYear W21115231142015 @default.
- W2111523114 countsByYear W21115231142016 @default.
- W2111523114 countsByYear W21115231142017 @default.
- W2111523114 countsByYear W21115231142018 @default.
- W2111523114 countsByYear W21115231142019 @default.
- W2111523114 countsByYear W21115231142020 @default.
- W2111523114 countsByYear W21115231142021 @default.
- W2111523114 countsByYear W21115231142022 @default.
- W2111523114 countsByYear W21115231142023 @default.
- W2111523114 crossrefType "journal-article" @default.
- W2111523114 hasAuthorship W2111523114A5003248918 @default.
- W2111523114 hasAuthorship W2111523114A5008570645 @default.
- W2111523114 hasAuthorship W2111523114A5015250792 @default.
- W2111523114 hasAuthorship W2111523114A5015860682 @default.
- W2111523114 hasAuthorship W2111523114A5029504846 @default.
- W2111523114 hasAuthorship W2111523114A5038105367 @default.
- W2111523114 hasAuthorship W2111523114A5050598836 @default.
- W2111523114 hasAuthorship W2111523114A5053242914 @default.
- W2111523114 hasAuthorship W2111523114A5066245741 @default.
- W2111523114 hasAuthorship W2111523114A5071866103 @default.
- W2111523114 hasAuthorship W2111523114A5085804612 @default.
- W2111523114 hasAuthorship W2111523114A5086076714 @default.
- W2111523114 hasBestOaLocation W21115231141 @default.
- W2111523114 hasConcept C104317684 @default.
- W2111523114 hasConcept C159047783 @default.
- W2111523114 hasConcept C159654299 @default.
- W2111523114 hasConcept C203014093 @default.
- W2111523114 hasConcept C2776460866 @default.
- W2111523114 hasConcept C2777334864 @default.
- W2111523114 hasConcept C2779000548 @default.
- W2111523114 hasConcept C2779489039 @default.
- W2111523114 hasConcept C2781090273 @default.
- W2111523114 hasConcept C40767141 @default.
- W2111523114 hasConcept C523546767 @default.
- W2111523114 hasConcept C54355233 @default.