Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111528243> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2111528243 abstract "Abstract Dorsal root ganglia neuronal cell bodies synthesize the vasodilator neuropeptide calcitonin gene–related peptide and innervate the blood vessels and spinal cord sites (laminae I and II) involved in blood pressure regulation. We previously demonstrated that calcitonin gene–related peptide mRNA content is significantly decreased in dorsal root ganglia and that immunoreactive calcitonin gene–related peptide levels are reduced in laminae I and II of the dorsal horn of the spinal cord in the spontaneously hypertensive rat compared with Wistar-Kyoto control rats. To determine whether neuronal calcitonin gene–related peptide expression is also altered in mineralocorticoid-salt hypertension, we quantified calcitonin gene–related peptide mRNA levels in dorsal root ganglia and protein content in laminae I and II of the spinal cord in rats with mineralocorticoid-salt–induced hypertension. To control for pellet implantation, saline drinking water, and/or uninephrectomy, four normotensive groups were similarly studied. By Northern hybridization analysis, the ratio of calcitonin gene–related peptide mRNA to 18S rRNA was increased approximately fivefold in hypertensive rats (33±7) compared with each of the four normotensive control groups (average of the four groups, 6±0.5; P <.01, mineralocorticoid-salt group versus each group). The density of the peptide, quantified by computer-assisted image analysis, in laminae I and II in the hypertensive rats was also increased (66±1 versus average of the four groups, 46±2 arbitrary units; P <.001, mineralocorticoid-salt group versus each group). In conclusion, neuronal levels of calcitonin gene–related peptide mRNA and protein are increased in mineralocorticoid-salt hypertension. Therefore, increased neuronal synthesis and available stores of this potent vasodilator may be compensatory responses to and thus attenuate the blood pressure elevation in this experimental model of hypertension." @default.
- W2111528243 created "2016-06-24" @default.
- W2111528243 creator A5005349109 @default.
- W2111528243 creator A5011379118 @default.
- W2111528243 creator A5032920452 @default.
- W2111528243 creator A5064118224 @default.
- W2111528243 creator A5087239740 @default.
- W2111528243 date "1995-06-01" @default.
- W2111528243 modified "2023-10-14" @default.
- W2111528243 title "Enhanced Neuronal Expression of Calcitonin Gene–Related Peptide in Mineralocorticoid-Salt Hypertension" @default.
- W2111528243 cites W1636890997 @default.
- W2111528243 cites W1964620096 @default.
- W2111528243 cites W1979882313 @default.
- W2111528243 cites W1986647797 @default.
- W2111528243 cites W1986998346 @default.
- W2111528243 cites W1989145539 @default.
- W2111528243 cites W2013724508 @default.
- W2111528243 cites W2031306451 @default.
- W2111528243 cites W2035581625 @default.
- W2111528243 cites W2035781216 @default.
- W2111528243 cites W2040306557 @default.
- W2111528243 cites W2053277833 @default.
- W2111528243 cites W2054706071 @default.
- W2111528243 cites W2055353756 @default.
- W2111528243 cites W2070049849 @default.
- W2111528243 cites W2086159324 @default.
- W2111528243 cites W2086273111 @default.
- W2111528243 cites W2092635728 @default.
- W2111528243 cites W2119540336 @default.
- W2111528243 cites W2125356206 @default.
- W2111528243 cites W2224676279 @default.
- W2111528243 cites W2000936713 @default.
- W2111528243 doi "https://doi.org/10.1161/01.hyp.25.6.1333" @default.
- W2111528243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7768583" @default.
- W2111528243 hasPublicationYear "1995" @default.
- W2111528243 type Work @default.
- W2111528243 sameAs 2111528243 @default.
- W2111528243 citedByCount "23" @default.
- W2111528243 countsByYear W21115282432012 @default.
- W2111528243 countsByYear W21115282432013 @default.
- W2111528243 countsByYear W21115282432014 @default.
- W2111528243 countsByYear W21115282432019 @default.
- W2111528243 countsByYear W21115282432022 @default.
- W2111528243 crossrefType "journal-article" @default.
- W2111528243 hasAuthorship W2111528243A5005349109 @default.
- W2111528243 hasAuthorship W2111528243A5011379118 @default.
- W2111528243 hasAuthorship W2111528243A5032920452 @default.
- W2111528243 hasAuthorship W2111528243A5064118224 @default.
- W2111528243 hasAuthorship W2111528243A5087239740 @default.
- W2111528243 hasConcept C104317684 @default.
- W2111528243 hasConcept C118303440 @default.
- W2111528243 hasConcept C126322002 @default.
- W2111528243 hasConcept C134018914 @default.
- W2111528243 hasConcept C150194340 @default.
- W2111528243 hasConcept C163170386 @default.
- W2111528243 hasConcept C169760540 @default.
- W2111528243 hasConcept C170493617 @default.
- W2111528243 hasConcept C2776069600 @default.
- W2111528243 hasConcept C2778525890 @default.
- W2111528243 hasConcept C2779627488 @default.
- W2111528243 hasConcept C2780775167 @default.
- W2111528243 hasConcept C55493867 @default.
- W2111528243 hasConcept C71924100 @default.
- W2111528243 hasConcept C86803240 @default.
- W2111528243 hasConcept C93984277 @default.
- W2111528243 hasConceptScore W2111528243C104317684 @default.
- W2111528243 hasConceptScore W2111528243C118303440 @default.
- W2111528243 hasConceptScore W2111528243C126322002 @default.
- W2111528243 hasConceptScore W2111528243C134018914 @default.
- W2111528243 hasConceptScore W2111528243C150194340 @default.
- W2111528243 hasConceptScore W2111528243C163170386 @default.
- W2111528243 hasConceptScore W2111528243C169760540 @default.
- W2111528243 hasConceptScore W2111528243C170493617 @default.
- W2111528243 hasConceptScore W2111528243C2776069600 @default.
- W2111528243 hasConceptScore W2111528243C2778525890 @default.
- W2111528243 hasConceptScore W2111528243C2779627488 @default.
- W2111528243 hasConceptScore W2111528243C2780775167 @default.
- W2111528243 hasConceptScore W2111528243C55493867 @default.
- W2111528243 hasConceptScore W2111528243C71924100 @default.
- W2111528243 hasConceptScore W2111528243C86803240 @default.
- W2111528243 hasConceptScore W2111528243C93984277 @default.
- W2111528243 hasLocation W21115282431 @default.
- W2111528243 hasLocation W21115282432 @default.
- W2111528243 hasOpenAccess W2111528243 @default.
- W2111528243 hasPrimaryLocation W21115282431 @default.
- W2111528243 hasRelatedWork W1943192612 @default.
- W2111528243 hasRelatedWork W1974979160 @default.
- W2111528243 hasRelatedWork W1981233567 @default.
- W2111528243 hasRelatedWork W2003450342 @default.
- W2111528243 hasRelatedWork W2011709261 @default.
- W2111528243 hasRelatedWork W2020160417 @default.
- W2111528243 hasRelatedWork W2046975916 @default.
- W2111528243 hasRelatedWork W2059702803 @default.
- W2111528243 hasRelatedWork W2085871851 @default.
- W2111528243 hasRelatedWork W2389891873 @default.
- W2111528243 isParatext "false" @default.
- W2111528243 isRetracted "false" @default.
- W2111528243 magId "2111528243" @default.
- W2111528243 workType "article" @default.