FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111531345> ?p ?o ?g. }

• W2111531345 endingPage "1061" @default.
• W2111531345 startingPage "1051" @default.
• W2111531345 abstract "Adenosine is generated during tissue hypoxia and stress, which reduces inflammation by suppressing the activity of most immune cells. Among its various actions, adenosine suppresses the production of proinflammatory cytokines including tumor necrosis factor (TNF)-alpha, through the cAMP-elevating A(2A) adenosine receptor (AR) subtype. In this study, we examined the signaling mechanisms by which A(2A)AR activation inhibits TNF-alpha production in thioglycollate-elicited mouse peritoneal macrophages. Pretreating murine macrophages with the nonselective AR agonist adenosine-5'-N-ethylcarboxamide (NECA), the A(2A)AR agonist 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosine (CGS 21680), or the cAMP-elevating agent forskolin reduced TNF-alpha production in response to lipopolysaccharide (LPS) by greater than 60%. All of these agents increased cAMP production in macrophages and activated protein kinase A (PKA). However, we were surprised to find that treating macrophages with three different PKA inhibitors or small interfering RNA-mediated knockdown of the exchange protein activated by cAMP (Epac-1) failed to block the suppressive actions of NECA or forskolin on LPS-induced TNF-alpha release. Instead, okadaic acid was effective at low concentrations that selectively inhibit protein serine/threonine phosphatases. Subsequent studies showed that NECA and forskolin decreased LPS-induced steady-state TNF-alpha mRNA levels; this effect was due to a decreased rate of transcription based on assays examining the rate of generation of primary TNF-alpha transcripts. Treatment with NECA or forskolin did not interfere with LPS-induced translocation or DNA binding of the RelA/p65 subunit of nuclear factor-kappaB or phosphorylation of inhibitor of nuclear factor-kappaB-alpha, extracellular signal-regulated kinase 1/2, c-Jun NH(2)-terminal kinase, or p38 kinase. Our results suggest that AR activation inhibits LPS-induced TNF-alpha production by murine macrophages at the level of gene transcription through a unique cAMP-dependent, but PKA- and Epac-independent, signaling pathway involving protein phosphatase activity." @default.
• W2111531345 created "2016-06-24" @default.
• W2111531345 creator A5047732235 @default.
• W2111531345 creator A5051204634 @default.
• W2111531345 creator A5060190034 @default.
• W2111531345 creator A5067930209 @default.
• W2111531345 date "2009-09-11" @default.
• W2111531345 modified "2023-09-24" @default.
• W2111531345 title "Adenosine Suppresses Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Murine Macrophages through a Protein Kinase A- and Exchange Protein Activated by cAMP-Independent Signaling Pathway" @default.
• W2111531345 cites W128911665 @default.
• W2111531345 cites W1491531822 @default.
• W2111531345 cites W1496188050 @default.
• W2111531345 cites W1535444616 @default.
• W2111531345 cites W1838015758 @default.
• W2111531345 cites W1885709862 @default.
• W2111531345 cites W1976382352 @default.
• W2111531345 cites W1985407729 @default.
• W2111531345 cites W1986269232 @default.
• W2111531345 cites W2003209941 @default.
• W2111531345 cites W2003483275 @default.
• W2111531345 cites W2003641968 @default.
• W2111531345 cites W2005645771 @default.
• W2111531345 cites W2049268565 @default.
• W2111531345 cites W2053642263 @default.
• W2111531345 cites W2054791134 @default.
• W2111531345 cites W2061130457 @default.
• W2111531345 cites W2063593049 @default.
• W2111531345 cites W2063716341 @default.
• W2111531345 cites W2067684973 @default.
• W2111531345 cites W2085024794 @default.
• W2111531345 cites W2085403057 @default.
• W2111531345 cites W2086543171 @default.
• W2111531345 cites W2091128689 @default.
• W2111531345 cites W2105420327 @default.
• W2111531345 cites W2105745549 @default.
• W2111531345 cites W2108244474 @default.
• W2111531345 cites W2110131271 @default.
• W2111531345 cites W2131083409 @default.
• W2111531345 cites W2132062123 @default.
• W2111531345 cites W2143563119 @default.
• W2111531345 cites W2144929276 @default.
• W2111531345 cites W2162984754 @default.
• W2111531345 cites W2327972260 @default.
• W2111531345 cites W2345510360 @default.
• W2111531345 cites W4293247451 @default.
• W2111531345 doi "https://doi.org/10.1124/jpet.109.157651" @default.
• W2111531345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2784717" @default.
• W2111531345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19749080" @default.
• W2111531345 hasPublicationYear "2009" @default.
• W2111531345 type Work @default.
• W2111531345 sameAs 2111531345 @default.
• W2111531345 citedByCount "39" @default.
• W2111531345 countsByYear W21115313452012 @default.
• W2111531345 countsByYear W21115313452013 @default.
• W2111531345 countsByYear W21115313452014 @default.
• W2111531345 countsByYear W21115313452015 @default.
• W2111531345 countsByYear W21115313452016 @default.
• W2111531345 countsByYear W21115313452017 @default.
• W2111531345 countsByYear W21115313452018 @default.
• W2111531345 countsByYear W21115313452019 @default.
• W2111531345 countsByYear W21115313452021 @default.
• W2111531345 countsByYear W21115313452022 @default.
• W2111531345 crossrefType "journal-article" @default.
• W2111531345 hasAuthorship W2111531345A5047732235 @default.
• W2111531345 hasAuthorship W2111531345A5051204634 @default.
• W2111531345 hasAuthorship W2111531345A5060190034 @default.
• W2111531345 hasAuthorship W2111531345A5067930209 @default.
• W2111531345 hasBestOaLocation W21115313452 @default.
• W2111531345 hasConcept C126322002 @default.
• W2111531345 hasConcept C134018914 @default.
• W2111531345 hasConcept C161473406 @default.
• W2111531345 hasConcept C164027704 @default.
• W2111531345 hasConcept C17991360 @default.
• W2111531345 hasConcept C184235292 @default.
• W2111531345 hasConcept C185592680 @default.
• W2111531345 hasConcept C24998067 @default.
• W2111531345 hasConcept C2776914184 @default.
• W2111531345 hasConcept C2776991684 @default.
• W2111531345 hasConcept C2779276759 @default.
• W2111531345 hasConcept C62478195 @default.
• W2111531345 hasConcept C71924100 @default.
• W2111531345 hasConcept C80631254 @default.
• W2111531345 hasConcept C86803240 @default.
• W2111531345 hasConcept C95444343 @default.
• W2111531345 hasConcept C97029542 @default.
• W2111531345 hasConceptScore W2111531345C126322002 @default.
• W2111531345 hasConceptScore W2111531345C134018914 @default.
• W2111531345 hasConceptScore W2111531345C161473406 @default.
• W2111531345 hasConceptScore W2111531345C164027704 @default.
• W2111531345 hasConceptScore W2111531345C17991360 @default.
• W2111531345 hasConceptScore W2111531345C184235292 @default.
• W2111531345 hasConceptScore W2111531345C185592680 @default.
• W2111531345 hasConceptScore W2111531345C24998067 @default.
• W2111531345 hasConceptScore W2111531345C2776914184 @default.
• W2111531345 hasConceptScore W2111531345C2776991684 @default.
• W2111531345 hasConceptScore W2111531345C2779276759 @default.
• W2111531345 hasConceptScore W2111531345C62478195 @default.
• W2111531345 hasConceptScore W2111531345C71924100 @default.

• next