Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111546430> ?p ?o ?g. }
- W2111546430 endingPage "689" @default.
- W2111546430 startingPage "681" @default.
- W2111546430 abstract "Phospholipase C-related but catalytically inactive protein (comprising PRIP-1 and PRIP-2 [officially designated PLCL1 and PLCL2]) was first identified in our laboratory, but the biological functions have remained elusive. Therefore, we generated Plcl1 and Plcl2 double-knockout mice (Plcl1tm1Mh; Plcl2tm1Tta) to gain insight into the biological function. Double-knockout mice apparently grew normally and became fertile; however, during animal maintenance, we noticed that mutant couples exhibited decreased litter events and litter size, indicating dysfunction of the reproductive system. Cross-mating experiments to discriminate whether males or females were defective indicated that the cause appeared to be on the female side. Mutant female mice had an apparently smaller uterus by gross anatomical observation and had more estrous days during the cycles. Levels of serum luteinizing hormone (LH) and follicle-stimulating hormone were measured for 5–6 consecutive days and were significantly higher in the mutant, which was also confirmed by examining the secretion of LH from the explant culture of anterior pituitary glands of wild-type and double-knockout mice. These results suggest that through gonadotropin secretion, PRIP plays an important role in female reproduction." @default.
- W2111546430 created "2016-06-24" @default.
- W2111546430 creator A5007218673 @default.
- W2111546430 creator A5010968082 @default.
- W2111546430 creator A5035944181 @default.
- W2111546430 creator A5044700950 @default.
- W2111546430 creator A5049877773 @default.
- W2111546430 creator A5055387451 @default.
- W2111546430 creator A5069538468 @default.
- W2111546430 creator A5076679264 @default.
- W2111546430 date "2009-10-01" @default.
- W2111546430 modified "2023-10-16" @default.
- W2111546430 title "Involvement of Phospholipase C-Related Inactive Protein in the Mouse Reproductive System Through the Regulation of Gonadotropin Levels1" @default.
- W2111546430 cites W140269156 @default.
- W2111546430 cites W1487317148 @default.
- W2111546430 cites W1535270542 @default.
- W2111546430 cites W1558700872 @default.
- W2111546430 cites W1718935338 @default.
- W2111546430 cites W1786443880 @default.
- W2111546430 cites W1895415431 @default.
- W2111546430 cites W1905489284 @default.
- W2111546430 cites W1964512812 @default.
- W2111546430 cites W1969107279 @default.
- W2111546430 cites W1972469975 @default.
- W2111546430 cites W1978127899 @default.
- W2111546430 cites W1982320266 @default.
- W2111546430 cites W1982448290 @default.
- W2111546430 cites W2018392296 @default.
- W2111546430 cites W2018774430 @default.
- W2111546430 cites W2023278519 @default.
- W2111546430 cites W2033302376 @default.
- W2111546430 cites W2036423270 @default.
- W2111546430 cites W2038696450 @default.
- W2111546430 cites W2045827480 @default.
- W2111546430 cites W2048316945 @default.
- W2111546430 cites W2050271834 @default.
- W2111546430 cites W2056439165 @default.
- W2111546430 cites W2057817161 @default.
- W2111546430 cites W2061613461 @default.
- W2111546430 cites W2074055278 @default.
- W2111546430 cites W2076859114 @default.
- W2111546430 cites W2077305451 @default.
- W2111546430 cites W2079733146 @default.
- W2111546430 cites W2083167565 @default.
- W2111546430 cites W2103208153 @default.
- W2111546430 cites W2108097122 @default.
- W2111546430 cites W2114622943 @default.
- W2111546430 cites W2121029752 @default.
- W2111546430 cites W2124966533 @default.
- W2111546430 cites W2129623694 @default.
- W2111546430 cites W2136122574 @default.
- W2111546430 cites W2154100802 @default.
- W2111546430 cites W2171145595 @default.
- W2111546430 cites W2344259232 @default.
- W2111546430 cites W324477760 @default.
- W2111546430 cites W4210958643 @default.
- W2111546430 cites W4242642640 @default.
- W2111546430 cites W4251510930 @default.
- W2111546430 cites W4361856109 @default.
- W2111546430 doi "https://doi.org/10.1095/biolreprod.109.076760" @default.
- W2111546430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553601" @default.
- W2111546430 hasPublicationYear "2009" @default.
- W2111546430 type Work @default.
- W2111546430 sameAs 2111546430 @default.
- W2111546430 citedByCount "38" @default.
- W2111546430 countsByYear W21115464302012 @default.
- W2111546430 countsByYear W21115464302013 @default.
- W2111546430 countsByYear W21115464302014 @default.
- W2111546430 countsByYear W21115464302015 @default.
- W2111546430 countsByYear W21115464302016 @default.
- W2111546430 countsByYear W21115464302017 @default.
- W2111546430 countsByYear W21115464302018 @default.
- W2111546430 countsByYear W21115464302019 @default.
- W2111546430 countsByYear W21115464302020 @default.
- W2111546430 countsByYear W21115464302021 @default.
- W2111546430 countsByYear W21115464302022 @default.
- W2111546430 countsByYear W21115464302023 @default.
- W2111546430 crossrefType "journal-article" @default.
- W2111546430 hasAuthorship W2111546430A5007218673 @default.
- W2111546430 hasAuthorship W2111546430A5010968082 @default.
- W2111546430 hasAuthorship W2111546430A5035944181 @default.
- W2111546430 hasAuthorship W2111546430A5044700950 @default.
- W2111546430 hasAuthorship W2111546430A5049877773 @default.
- W2111546430 hasAuthorship W2111546430A5055387451 @default.
- W2111546430 hasAuthorship W2111546430A5069538468 @default.
- W2111546430 hasAuthorship W2111546430A5076679264 @default.
- W2111546430 hasBestOaLocation W21115464301 @default.
- W2111546430 hasConcept C104317684 @default.
- W2111546430 hasConcept C126322002 @default.
- W2111546430 hasConcept C134018914 @default.
- W2111546430 hasConcept C143065580 @default.
- W2111546430 hasConcept C16685009 @default.
- W2111546430 hasConcept C170493617 @default.
- W2111546430 hasConcept C182704531 @default.
- W2111546430 hasConcept C1998276 @default.
- W2111546430 hasConcept C2778575703 @default.
- W2111546430 hasConcept C2778597717 @default.
- W2111546430 hasConcept C2778782382 @default.