FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111546510> ?p ?o ?g. }

• W2111546510 endingPage "618" @default.
• W2111546510 startingPage "609" @default.
• W2111546510 abstract "The present study was designed to assess the evolution of simeprevir-resistant variants (amino acid substitutions of aa80, aa155, aa156, and aa168 positions in HCV NS3 region) over time in virological non-responders (patients with positive HCV-RNA during and at end of treatment). The study enrolled 136 patients infected with HCV genotype 1b who received 12-week simeprevir-PEG-IFN-ribavirin therapy, and data of 87 patients were available for analysis. Twelve patients (14%) were considered virological non-responders, including 9 (75%) who showed absolute no-response (HCV RNA: ≥3.0 log IU/ml at 12 weeks after start of therapy). Multivariate analysis of these patients identified lack of response to prior treatment, use of low ribavirin dose, and old age as independent and significant determinants of virological non-response. Using ultra-deep sequencing, de novo variants of D168 were detected in all of 9 absolute non-responders. The majority of these variants emerged within 5 weeks of triple therapy. In comparison, de novo variants of Q80 were detected in only 3 of 9 absolute non-responders and emerged at 6–12 weeks. Variants of Q80 detected at baseline increased during the course of treatment in 5 of 9 absolute non-responders, while no such increase was noted in variants of R155 and/or A156 detected at baseline during the 12-week course. De novo variants of R155 and/or A156 were not detected in this study. The results demonstrated the emergence of simeprevir-resistant variants during the early stage of triple therapy. J. Med. Virol. 87:609–618, 2015. © 2015 Wiley Periodicals, Inc." @default.
• W2111546510 created "2016-06-24" @default.
• W2111546510 creator A5010056452 @default.
• W2111546510 creator A5024325916 @default.
• W2111546510 creator A5026182073 @default.
• W2111546510 creator A5031710130 @default.
• W2111546510 creator A5044932403 @default.
• W2111546510 creator A5057057637 @default.
• W2111546510 creator A5066429603 @default.
• W2111546510 creator A5071497400 @default.
• W2111546510 creator A5084522512 @default.
• W2111546510 creator A5089243471 @default.
• W2111546510 date "2015-02-05" @default.
• W2111546510 modified "2023-10-15" @default.
• W2111546510 title "Evolution of simeprevir-resistant variants in virological non-responders infected with HCV genotype 1b" @default.
• W2111546510 cites W1551301313 @default.
• W2111546510 cites W1591685498 @default.
• W2111546510 cites W1887558851 @default.
• W2111546510 cites W1967751250 @default.
• W2111546510 cites W1971792395 @default.
• W2111546510 cites W1978892007 @default.
• W2111546510 cites W1979174109 @default.
• W2111546510 cites W1983765304 @default.
• W2111546510 cites W1986564802 @default.
• W2111546510 cites W1987584200 @default.
• W2111546510 cites W1997249384 @default.
• W2111546510 cites W2001129358 @default.
• W2111546510 cites W2014509089 @default.
• W2111546510 cites W2016205218 @default.
• W2111546510 cites W2019915078 @default.
• W2111546510 cites W2026614040 @default.
• W2111546510 cites W2026828547 @default.
• W2111546510 cites W2032624194 @default.
• W2111546510 cites W2041421438 @default.
• W2111546510 cites W2047911275 @default.
• W2111546510 cites W2051595037 @default.
• W2111546510 cites W2052005188 @default.
• W2111546510 cites W2062414266 @default.
• W2111546510 cites W2063285149 @default.
• W2111546510 cites W2066081568 @default.
• W2111546510 cites W2075660007 @default.
• W2111546510 cites W2086414517 @default.
• W2111546510 cites W2094972821 @default.
• W2111546510 cites W2100485606 @default.
• W2111546510 cites W2100797437 @default.
• W2111546510 cites W2102079012 @default.
• W2111546510 cites W2103753697 @default.
• W2111546510 cites W2116848809 @default.
• W2111546510 cites W2119764771 @default.
• W2111546510 cites W2127189337 @default.
• W2111546510 cites W2143244227 @default.
• W2111546510 cites W2143613583 @default.
• W2111546510 cites W2155047706 @default.
• W2111546510 doi "https://doi.org/10.1002/jmv.24113" @default.
• W2111546510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25655809" @default.
• W2111546510 hasPublicationYear "2015" @default.
• W2111546510 type Work @default.
• W2111546510 sameAs 2111546510 @default.
• W2111546510 citedByCount "5" @default.
• W2111546510 countsByYear W21115465102016 @default.
• W2111546510 countsByYear W21115465102017 @default.
• W2111546510 crossrefType "journal-article" @default.
• W2111546510 hasAuthorship W2111546510A5010056452 @default.
• W2111546510 hasAuthorship W2111546510A5024325916 @default.
• W2111546510 hasAuthorship W2111546510A5026182073 @default.
• W2111546510 hasAuthorship W2111546510A5031710130 @default.
• W2111546510 hasAuthorship W2111546510A5044932403 @default.
• W2111546510 hasAuthorship W2111546510A5057057637 @default.
• W2111546510 hasAuthorship W2111546510A5066429603 @default.
• W2111546510 hasAuthorship W2111546510A5071497400 @default.
• W2111546510 hasAuthorship W2111546510A5084522512 @default.
• W2111546510 hasAuthorship W2111546510A5089243471 @default.
• W2111546510 hasConcept C104317684 @default.
• W2111546510 hasConcept C126322002 @default.
• W2111546510 hasConcept C135763542 @default.
• W2111546510 hasConcept C159047783 @default.
• W2111546510 hasConcept C2522874641 @default.
• W2111546510 hasConcept C2776408679 @default.
• W2111546510 hasConcept C2778986448 @default.
• W2111546510 hasConcept C2780040827 @default.
• W2111546510 hasConcept C54355233 @default.
• W2111546510 hasConcept C71924100 @default.
• W2111546510 hasConcept C86803240 @default.
• W2111546510 hasConceptScore W2111546510C104317684 @default.
• W2111546510 hasConceptScore W2111546510C126322002 @default.
• W2111546510 hasConceptScore W2111546510C135763542 @default.
• W2111546510 hasConceptScore W2111546510C159047783 @default.
• W2111546510 hasConceptScore W2111546510C2522874641 @default.
• W2111546510 hasConceptScore W2111546510C2776408679 @default.
• W2111546510 hasConceptScore W2111546510C2778986448 @default.
• W2111546510 hasConceptScore W2111546510C2780040827 @default.
• W2111546510 hasConceptScore W2111546510C54355233 @default.
• W2111546510 hasConceptScore W2111546510C71924100 @default.
• W2111546510 hasConceptScore W2111546510C86803240 @default.
• W2111546510 hasIssue "4" @default.
• W2111546510 hasLocation W21115465101 @default.
• W2111546510 hasLocation W21115465102 @default.
• W2111546510 hasOpenAccess W2111546510 @default.

• next