FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111546536> ?p ?o ?g. }

• W2111546536 endingPage "1258" @default.
• W2111546536 startingPage "1253" @default.
• W2111546536 abstract "The effects of glucose, arginine, and glucagon on beta-cell function as well as alpha-cell response to arginine were studied in a family with mitochondrial diabetes.The function of alpha- and beta-cells was assessed in all five siblings carrying the mitochondrial tRNA Leu(UUR) gene mutation at position 3243 and compared with six sex-, age-, and weight-matched control subjects. Insulin and C-peptide responses were evaluated by intravenous glucagon application, intravenous arginine stimulation test, and intravenous glucose tolerance test. Glucagon secretion was assessed during the arginine stimulation test.The glucose disappearance constant (K(g)) value (mean +/- SEM 0.61 +/- 0.04 vs. 1.1 +/- 0.04, P = 0.0002) as well as the acute insulin response to glucose (area under the curve [AUC] 0-10 min, 77.7 +/- 50.7 vs. 1,352.3 +/- 191.5 pmol/l, P = 0.0004) were decreased in all patients. Similarly, glucagon-stimulated C-peptide response was also impaired (728 +/- 111.4 vs. 1,526.7 +/- 157.7 pmol/l, P = 0.005), whereas the insulin response to arginine (AUC) was normal (1,346.9 +/- 710.8 vs. 1,083.2 +/- 132.5 pmol/l, P = 0.699). Acute glucagon response to arginine (AUC) was normal but tended to be higher in the patients than in the control subjects (181.7 +/- 47.5 vs. 90.0 +/- 21.1 pmol/l, P = 0.099).This study shows impaired insulin and C-peptide secretion in response to a glucose challenge and to glucagon stimulation in diabetic patients with mitochondrial tRNA Leu(UUR) gene mutation, although insulin and glucagon secretory responses to arginine were normal." @default.
• W2111546536 created "2016-06-24" @default.
• W2111546536 creator A5007837138 @default.
• W2111546536 creator A5031343318 @default.
• W2111546536 creator A5054303361 @default.
• W2111546536 creator A5060814048 @default.
• W2111546536 creator A5076416009 @default.
• W2111546536 date "2001-07-01" @default.
• W2111546536 modified "2023-09-24" @default.
• W2111546536 title "Diminished Insulin Secretory Response to Glucose but Normal Insulin and Glucagon Secretory Responses to Arginine in a Family With Maternally Inherited Diabetes and Deafness Caused by Mitochondrial tRNALEU(UUR) Gene Mutation" @default.
• W2111546536 cites W1943507587 @default.
• W2111546536 cites W1966852147 @default.
• W2111546536 cites W1979730424 @default.
• W2111546536 cites W2027103431 @default.
• W2111546536 cites W2037204981 @default.
• W2111546536 cites W2050885391 @default.
• W2111546536 cites W2052054828 @default.
• W2111546536 cites W2052254021 @default.
• W2111546536 cites W2054011043 @default.
• W2111546536 cites W2054201069 @default.
• W2111546536 cites W2055023561 @default.
• W2111546536 cites W2057613976 @default.
• W2111546536 cites W2068466003 @default.
• W2111546536 cites W2085426114 @default.
• W2111546536 cites W2093187370 @default.
• W2111546536 cites W2102254551 @default.
• W2111546536 cites W2115975835 @default.
• W2111546536 cites W2117894376 @default.
• W2111546536 cites W2122603966 @default.
• W2111546536 cites W2146415791 @default.
• W2111546536 cites W2167981935 @default.
• W2111546536 cites W2168456268 @default.
• W2111546536 cites W2338125871 @default.
• W2111546536 cites W2410425695 @default.
• W2111546536 cites W4233656963 @default.
• W2111546536 cites W4235007813 @default.
• W2111546536 cites W4235302200 @default.
• W2111546536 cites W4238396713 @default.
• W2111546536 cites W4238964466 @default.
• W2111546536 cites W4245532469 @default.
• W2111546536 doi "https://doi.org/10.2337/diacare.24.7.1253" @default.
• W2111546536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11423511" @default.
• W2111546536 hasPublicationYear "2001" @default.
• W2111546536 type Work @default.
• W2111546536 sameAs 2111546536 @default.
• W2111546536 citedByCount "32" @default.
• W2111546536 countsByYear W21115465362012 @default.
• W2111546536 countsByYear W21115465362013 @default.
• W2111546536 countsByYear W21115465362014 @default.
• W2111546536 countsByYear W21115465362015 @default.
• W2111546536 countsByYear W21115465362016 @default.
• W2111546536 countsByYear W21115465362017 @default.
• W2111546536 countsByYear W21115465362020 @default.
• W2111546536 countsByYear W21115465362021 @default.
• W2111546536 crossrefType "journal-article" @default.
• W2111546536 hasAuthorship W2111546536A5007837138 @default.
• W2111546536 hasAuthorship W2111546536A5031343318 @default.
• W2111546536 hasAuthorship W2111546536A5054303361 @default.
• W2111546536 hasAuthorship W2111546536A5060814048 @default.
• W2111546536 hasAuthorship W2111546536A5076416009 @default.
• W2111546536 hasBestOaLocation W21115465361 @default.
• W2111546536 hasConcept C126322002 @default.
• W2111546536 hasConcept C134018914 @default.
• W2111546536 hasConcept C165220095 @default.
• W2111546536 hasConcept C24998067 @default.
• W2111546536 hasConcept C2776828364 @default.
• W2111546536 hasConcept C2777391703 @default.
• W2111546536 hasConcept C2777468819 @default.
• W2111546536 hasConcept C2778563252 @default.
• W2111546536 hasConcept C2779306644 @default.
• W2111546536 hasConcept C2780352109 @default.
• W2111546536 hasConcept C2780833929 @default.
• W2111546536 hasConcept C515207424 @default.
• W2111546536 hasConcept C55493867 @default.
• W2111546536 hasConcept C555293320 @default.
• W2111546536 hasConcept C71924100 @default.
• W2111546536 hasConcept C86803240 @default.
• W2111546536 hasConceptScore W2111546536C126322002 @default.
• W2111546536 hasConceptScore W2111546536C134018914 @default.
• W2111546536 hasConceptScore W2111546536C165220095 @default.
• W2111546536 hasConceptScore W2111546536C24998067 @default.
• W2111546536 hasConceptScore W2111546536C2776828364 @default.
• W2111546536 hasConceptScore W2111546536C2777391703 @default.
• W2111546536 hasConceptScore W2111546536C2777468819 @default.
• W2111546536 hasConceptScore W2111546536C2778563252 @default.
• W2111546536 hasConceptScore W2111546536C2779306644 @default.
• W2111546536 hasConceptScore W2111546536C2780352109 @default.
• W2111546536 hasConceptScore W2111546536C2780833929 @default.
• W2111546536 hasConceptScore W2111546536C515207424 @default.
• W2111546536 hasConceptScore W2111546536C55493867 @default.
• W2111546536 hasConceptScore W2111546536C555293320 @default.
• W2111546536 hasConceptScore W2111546536C71924100 @default.
• W2111546536 hasConceptScore W2111546536C86803240 @default.
• W2111546536 hasIssue "7" @default.
• W2111546536 hasLocation W21115465361 @default.
• W2111546536 hasLocation W21115465362 @default.
• W2111546536 hasOpenAccess W2111546536 @default.
• W2111546536 hasPrimaryLocation W21115465361 @default.

• next