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- W2111567427 abstract "Birds of a tether: A tethering strategy for the site-directed discovery of low-molecular-weight fragments that bind weakly to defined protein surfaces is described. A solvent-exposed protein thiol captures acrylamide-modified fragments in a conjugate addition reaction that requires a template to produce a measureable quantity of protein–fragment adduct, which can be rapidly identified by mass spectrometry. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W2111567427 date "2012-10-02" @default.
- W2111567427 modified "2023-10-17" @default.
- W2111567427 title "Kinetic Template-Guided Tethering of Fragments" @default.
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- W2111567427 doi "https://doi.org/10.1002/cmdc.201200404" @default.
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