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- W2111570260 abstract "Acute cough is a widespread symptom in children, the disproportionate use of antibiotic prescription increases parental satisfaction, although URTI are generally self-limiting. We analyzed treatment effect of antibiotics and symptomatic drugs (antitussives and mucolitics) in two trials on URTI-related cough. The first retrospective study involved 59 children with acute moist cough, treated with antibiotics or inhaled mucoactive drugs. Cough was measured, by means of a verbal category descriptive (VCD) score. The second prospective study included 305 children with acute cough. Severity, frequency and type of cough were assessed after 6 days of treatment using a standardized questionnaire. In the retrospective series, patients treated with inhaled mucoactive drugs (sobrerol or N-acetylcysteine) showed a significant improvement after 7 days compared with the group receiving antimicrobial therapy (p In the prospective study children treated with antibiotics alone showed lower percentage of cough resolution after 6 days than patient treated with antitussive only, no difference was detected between children treated with antitussive alone vs patients receiving antibiotics and antitussives. The use of levodropropizine demonstrated a statistically significant effect in terms of cough resolution as compared to centrally acting antitussive drugs (codeine or cloperastine) (47% vs. 28%, p = 0.0012). Our analysis of the studies showed that the effect of antibiotics on acute cough caused by URTI is inferior to symptomatic therapy. Antibiotics are not generally useful for treating cough, both alone and in association with antitussives. Mostly antibiotics is of little benefit and is outweighed by the adverse effects." @default.
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- W2111570260 date "2013-09-01" @default.
- W2111570260 modified "2023-09-27" @default.
- W2111570260 title "Antibiotic or symptomatic therapy in URTI-related pediatric acute cough?" @default.
- W2111570260 hasPublicationYear "2013" @default.
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