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- W2111580003 abstract "The purpose of this study was to determine if the age-related decrease in norepinephrine (NE) release from cardiac adrenergic nerve terminals is due to a defect in Ca2+ movement into the nerve terminal or to an alteration in Ca2+ activation of intracellular events leading to NE release. NE release was assessed in cardiac synaptosomes prepared from 6- and 24-month-old male F344 rats. K(+)-induced NE release was significantly greater in young vs old rats. Raising extracellular [Ca2+] increased NE release, but NE release always remained higher in the younger animals. Ionomycin, a Ca2+ ionophore, induced NE release from cardiac synaptosomes, and there was no age difference in the response. The age-related reduction in NE release induced by K+ and the capacity of ionomycin to induce similar NE release in young and old cardiac synaptosomes points to a reduction in Ca2+ movement during depolarization." @default.
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- W2111580003 date "1995-11-01" @default.
- W2111580003 modified "2023-10-14" @default.
- W2111580003 title "Age-Related Changes in Cardiac Norepinephrine Release: Role of Calcium Movement" @default.
- W2111580003 doi "https://doi.org/10.1093/gerona/50a.6.b358" @default.
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