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• W2111600922 endingPage "1755" @default.
• W2111600922 startingPage "1749" @default.
• W2111600922 abstract "Migrating white sturgeon (Acipenser transmontamus) may be subject to agricultural, municipal, and industrial wastewater effluents that likely contain different classes of endocrine-disrupting contaminants. Concern is mounting about the negative effects of environmental estrogens on fish reproduction; however, in environmental mixtures, the affects from estrogenic compounds may be suppressed by aryl hydrocarbon receptor (AhR) ligands. Indeed, reductions in 17beta-estradiol-induced (0.01 and 1 mg/kg) vitellogenin (VTG) levels were observed in white sturgeon coinjected with beta-naphthoflavone (BNF; 50 mg/kg), a model for contaminants that activate the AhR. Variation in the time of injection was used to attempt to correlate VTG inhibition to ethoxyresorufin-O-deethylase activity. No evidence was found to suggest that the inhibition of VTG is a direct result of enhanced estrogen metabolism by BNF-induced enzymes. Results of the present study are relevant for monitoring programs that measure VTG, because these results show that AhR-active environmental contaminants can repress VTG synthesis, which commonly is used as an indicator of estrogen-mimicking contaminants. Furthermore, suppression of natural estrogen signaling by AhR agonists may have significant effects on fish reproduction." @default.
• W2111600922 created "2016-06-24" @default.
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• W2111600922 date "2009-08-01" @default.
• W2111600922 modified "2023-10-10" @default.
• W2111600922 title "REDUCTION OF VITELLOGENIN SYNTHESIS BY AN ARYL HYDROCARBON RECEPTOR AGONIST IN THE WHITE STURGEON (ACIPENSER TRANSMONTAMUS)" @default.
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• W2111600922 doi "https://doi.org/10.1897/08-481.1" @default.
• W2111600922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2858920" @default.
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• W2111600922 hasPublicationYear "2009" @default.
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