FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111607689> ?p ?o ?g. }

• W2111607689 endingPage "2187" @default.
• W2111607689 startingPage "2178" @default.
• W2111607689 abstract "A structure-activity relationship study was carried out to facilitate development of inhibitors of dengue virus infectivity. Previous studies demonstrated that a highly charged heparan sulfate, a heparin-like glycosaminoglycan found on the cell surface, serves as a receptor for dengue virus by binding to its envelope protein. Interventions that disrupt this binding effectively inhibit infectivity. A competitive binding assay was developed to screen polyanionic compounds for activity in preventing binding of dengue virus envelope protein to immobilized heparin; compounds tested included drugs, excipients, and larger glycosaminoglycans and their semisynthetic derivatives. Results of this competitive binding assay were used to select agents for detailed evaluation of interactions by surface plasmon resonance spectroscopy, which afforded binding on-rates, off-rates, and dissociation constants. From these data, an understanding of the structural requirements for polyanion binding to dengue virus envelope protein has been established." @default.
• W2111607689 created "2016-06-24" @default.
• W2111607689 creator A5007419204 @default.
• W2111607689 creator A5013532873 @default.
• W2111607689 creator A5018092414 @default.
• W2111607689 creator A5021628843 @default.
• W2111607689 creator A5033823794 @default.
• W2111607689 creator A5048213355 @default.
• W2111607689 creator A5056210370 @default.
• W2111607689 creator A5064393926 @default.
• W2111607689 date "2001-05-09" @default.
• W2111607689 modified "2023-09-26" @default.
• W2111607689 title "Probing the Interaction of Dengue Virus Envelope Protein with Heparin: Assessment of Glycosaminoglycan-Derived Inhibitors" @default.
• W2111607689 cites W1964763534 @default.
• W2111607689 cites W1967227961 @default.
• W2111607689 cites W1968499991 @default.
• W2111607689 cites W1991079040 @default.
• W2111607689 cites W2007509169 @default.
• W2111607689 cites W2039630770 @default.
• W2111607689 cites W2049176098 @default.
• W2111607689 cites W2100837269 @default.
• W2111607689 cites W2112708564 @default.
• W2111607689 cites W2124483903 @default.
• W2111607689 cites W2161616631 @default.
• W2111607689 cites W2321734777 @default.
• W2111607689 cites W2030147437 @default.
• W2111607689 doi "https://doi.org/10.1021/jm000412i" @default.
• W2111607689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11405655" @default.
• W2111607689 hasPublicationYear "2001" @default.
• W2111607689 type Work @default.
• W2111607689 sameAs 2111607689 @default.
• W2111607689 citedByCount "103" @default.
• W2111607689 countsByYear W21116076892012 @default.
• W2111607689 countsByYear W21116076892013 @default.
• W2111607689 countsByYear W21116076892014 @default.
• W2111607689 countsByYear W21116076892015 @default.
• W2111607689 countsByYear W21116076892016 @default.
• W2111607689 countsByYear W21116076892017 @default.
• W2111607689 countsByYear W21116076892018 @default.
• W2111607689 countsByYear W21116076892019 @default.
• W2111607689 countsByYear W21116076892020 @default.
• W2111607689 countsByYear W21116076892021 @default.
• W2111607689 countsByYear W21116076892022 @default.
• W2111607689 crossrefType "journal-article" @default.
• W2111607689 hasAuthorship W2111607689A5007419204 @default.
• W2111607689 hasAuthorship W2111607689A5013532873 @default.
• W2111607689 hasAuthorship W2111607689A5018092414 @default.
• W2111607689 hasAuthorship W2111607689A5021628843 @default.
• W2111607689 hasAuthorship W2111607689A5033823794 @default.
• W2111607689 hasAuthorship W2111607689A5048213355 @default.
• W2111607689 hasAuthorship W2111607689A5056210370 @default.
• W2111607689 hasAuthorship W2111607689A5064393926 @default.
• W2111607689 hasConcept C106358424 @default.
• W2111607689 hasConcept C106847996 @default.
• W2111607689 hasConcept C107824862 @default.
• W2111607689 hasConcept C108625454 @default.
• W2111607689 hasConcept C153074725 @default.
• W2111607689 hasConcept C155672457 @default.
• W2111607689 hasConcept C159047783 @default.
• W2111607689 hasConcept C170493617 @default.
• W2111607689 hasConcept C171250308 @default.
• W2111607689 hasConcept C185592680 @default.
• W2111607689 hasConcept C192562407 @default.
• W2111607689 hasConcept C2522874641 @default.
• W2111607689 hasConcept C2777557582 @default.
• W2111607689 hasConcept C2778041096 @default.
• W2111607689 hasConcept C2779635636 @default.
• W2111607689 hasConcept C51639874 @default.
• W2111607689 hasConcept C533803919 @default.
• W2111607689 hasConcept C55493867 @default.
• W2111607689 hasConcept C74998103 @default.
• W2111607689 hasConcept C86803240 @default.
• W2111607689 hasConcept C97380033 @default.
• W2111607689 hasConceptScore W2111607689C106358424 @default.
• W2111607689 hasConceptScore W2111607689C106847996 @default.
• W2111607689 hasConceptScore W2111607689C107824862 @default.
• W2111607689 hasConceptScore W2111607689C108625454 @default.
• W2111607689 hasConceptScore W2111607689C153074725 @default.
• W2111607689 hasConceptScore W2111607689C155672457 @default.
• W2111607689 hasConceptScore W2111607689C159047783 @default.
• W2111607689 hasConceptScore W2111607689C170493617 @default.
• W2111607689 hasConceptScore W2111607689C171250308 @default.
• W2111607689 hasConceptScore W2111607689C185592680 @default.
• W2111607689 hasConceptScore W2111607689C192562407 @default.
• W2111607689 hasConceptScore W2111607689C2522874641 @default.
• W2111607689 hasConceptScore W2111607689C2777557582 @default.
• W2111607689 hasConceptScore W2111607689C2778041096 @default.
• W2111607689 hasConceptScore W2111607689C2779635636 @default.
• W2111607689 hasConceptScore W2111607689C51639874 @default.
• W2111607689 hasConceptScore W2111607689C533803919 @default.
• W2111607689 hasConceptScore W2111607689C55493867 @default.
• W2111607689 hasConceptScore W2111607689C74998103 @default.
• W2111607689 hasConceptScore W2111607689C86803240 @default.
• W2111607689 hasConceptScore W2111607689C97380033 @default.
• W2111607689 hasIssue "13" @default.
• W2111607689 hasLocation W21116076891 @default.
• W2111607689 hasLocation W21116076892 @default.
• W2111607689 hasOpenAccess W2111607689 @default.

• next