Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111609979> ?p ?o ?g. }
- W2111609979 endingPage "293" @default.
- W2111609979 startingPage "282" @default.
- W2111609979 abstract "Kv4 channels regulate the backpropagation of action potentials (b-AP) and have been implicated in the modulation of long-term potentiation (LTP). Here we showed that blockade of Kv4 channels by the scorpion toxin AmmTX3 impaired reference memory in a radial maze task. In vivo, AmmTX3 intracerebroventricular (i.c.v.) infusion increased and stabilized the EPSP-spike (E-S) component of LTP in the dentate gyrus (DG), with no effect on basal transmission or short-term plasticity. This increase in E-S potentiation duration could result from the combination of an increase in excitability of DG granular cells with a reduction of GABAergic inhibition, leading to a strong reduction of input specificity. Radioactive in situ hybridization (ISH) was used to evaluate the amounts of Kv4.2 and Kv4.3 mRNA in brain structures at different stages of a spatial learning task in naive, pseudoconditioned, and conditioned rats. Significant differences in Kv4.2 and Kv4.3 mRNA levels were observed between conditioned and pseudoconditioned rats. Kv4.2 and Kv4.3 mRNA levels were transiently up-regulated in the striatum, nucleus accumbens, retrosplenial, and cingulate cortices during early stages of learning, suggesting an involvement in the switch from egocentric to allocentric strategies. Spatial learning performance was positively correlated with the levels of Kv4.2 and Kv4.3 mRNAs in several of these brain structures. Altogether our findings suggest that Kv4 channels could increase the signal-to-noise ratio during information acquisition, thereby allowing a better encoding of the memory trace." @default.
- W2111609979 created "2016-06-24" @default.
- W2111609979 creator A5004545784 @default.
- W2111609979 creator A5007218897 @default.
- W2111609979 creator A5028089147 @default.
- W2111609979 creator A5029317841 @default.
- W2111609979 creator A5053187583 @default.
- W2111609979 creator A5083574223 @default.
- W2111609979 date "2012-06-14" @default.
- W2111609979 modified "2023-10-18" @default.
- W2111609979 title "Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats" @default.
- W2111609979 cites W1481762643 @default.
- W2111609979 cites W1520854803 @default.
- W2111609979 cites W1588205321 @default.
- W2111609979 cites W1889544552 @default.
- W2111609979 cites W1912830475 @default.
- W2111609979 cites W1967193478 @default.
- W2111609979 cites W1968350056 @default.
- W2111609979 cites W1968460764 @default.
- W2111609979 cites W1969348498 @default.
- W2111609979 cites W1970639889 @default.
- W2111609979 cites W1973546928 @default.
- W2111609979 cites W1975376465 @default.
- W2111609979 cites W1976978180 @default.
- W2111609979 cites W1977419340 @default.
- W2111609979 cites W1981847881 @default.
- W2111609979 cites W1982359426 @default.
- W2111609979 cites W1984708543 @default.
- W2111609979 cites W1985640395 @default.
- W2111609979 cites W1987953048 @default.
- W2111609979 cites W1989545342 @default.
- W2111609979 cites W1993443442 @default.
- W2111609979 cites W1993725941 @default.
- W2111609979 cites W1994892862 @default.
- W2111609979 cites W1995963373 @default.
- W2111609979 cites W1996434213 @default.
- W2111609979 cites W1996623546 @default.
- W2111609979 cites W2000502184 @default.
- W2111609979 cites W2000629783 @default.
- W2111609979 cites W2004689558 @default.
- W2111609979 cites W2008774676 @default.
- W2111609979 cites W2009030825 @default.
- W2111609979 cites W2009782005 @default.
- W2111609979 cites W2009846440 @default.
- W2111609979 cites W2010920096 @default.
- W2111609979 cites W2012763091 @default.
- W2111609979 cites W2014571080 @default.
- W2111609979 cites W2016261700 @default.
- W2111609979 cites W2019132400 @default.
- W2111609979 cites W2022974589 @default.
- W2111609979 cites W2023238505 @default.
- W2111609979 cites W2028945107 @default.
- W2111609979 cites W2029979198 @default.
- W2111609979 cites W2032403548 @default.
- W2111609979 cites W2033347348 @default.
- W2111609979 cites W2035900509 @default.
- W2111609979 cites W2044670260 @default.
- W2111609979 cites W2048234407 @default.
- W2111609979 cites W2049856923 @default.
- W2111609979 cites W2050260788 @default.
- W2111609979 cites W2051005796 @default.
- W2111609979 cites W2052789328 @default.
- W2111609979 cites W2053460595 @default.
- W2111609979 cites W2057790564 @default.
- W2111609979 cites W2058127867 @default.
- W2111609979 cites W2061008935 @default.
- W2111609979 cites W2061070105 @default.
- W2111609979 cites W2064244595 @default.
- W2111609979 cites W2064978706 @default.
- W2111609979 cites W2070680069 @default.
- W2111609979 cites W2072233684 @default.
- W2111609979 cites W2075213530 @default.
- W2111609979 cites W2075588319 @default.
- W2111609979 cites W2076854235 @default.
- W2111609979 cites W2077849980 @default.
- W2111609979 cites W2078963381 @default.
- W2111609979 cites W2092734837 @default.
- W2111609979 cites W2097480079 @default.
- W2111609979 cites W2097713433 @default.
- W2111609979 cites W2102994933 @default.
- W2111609979 cites W2106043907 @default.
- W2111609979 cites W2111762910 @default.
- W2111609979 cites W2115753419 @default.
- W2111609979 cites W2116252371 @default.
- W2111609979 cites W2117443520 @default.
- W2111609979 cites W2117911593 @default.
- W2111609979 cites W2120610786 @default.
- W2111609979 cites W2124377932 @default.
- W2111609979 cites W2130092107 @default.
- W2111609979 cites W2131956671 @default.
- W2111609979 cites W2137129753 @default.
- W2111609979 cites W2141584191 @default.
- W2111609979 cites W2149303478 @default.
- W2111609979 cites W2163781490 @default.
- W2111609979 cites W2164009595 @default.
- W2111609979 cites W2166494613 @default.
- W2111609979 cites W2167415113 @default.
- W2111609979 cites W2332249202 @default.