FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111624324> ?p ?o ?g. }

• W2111624324 endingPage "5424" @default.
• W2111624324 startingPage "5415" @default.
• W2111624324 abstract "ABSTRACT Almost all small eukaryotic RNAs are processed from transiently stabilized 3′-extended forms. A key question is how and why such intermediates are stabilized and how they can then be processed to the mature RNA. Here we report that yeast U3 is also processed from a 3′-extended precursor. The major 3′-extended forms of U3 (U3-3′I and -II) lack the cap trimethylation present in mature U3 and are not associated with small nucleolar RNP (snoRNP) proteins that bind mature U3, i.e., Nop1p, Nop56p, and Nop58p. Depletion of Nop58p leads to the loss of mature U3 but increases the level of U3-3′I and -II, indicating a requirement for the snoRNP proteins for final maturation. Pre-U3 is cleaved by the endonuclease Rnt1p, but U3-3′I and -II do not extend to the Rnt1p cleavage sites. Rather, they terminate at poly(U) tracts, suggesting that they might be bound by Lhp1p (the yeast homologue of La). Immunoprecipitation of Lhp1p fused to Staphylococcus aureus protein A resulted in coprecipitation of both U3-3′I and -II. Deletion of LHP1 , which is nonessential, led to the loss of U3-3′I and -II. We conclude that pre-U3 is cleaved by Rnt1p, followed by exonuclease digestion to U3-3′I and -II. These species are stabilized against continued degradation by binding of Lhp1p. Displacement of Lhp1p by binding of the snoRNP proteins allows final maturation, which involves the exosome complex of 3′→5′ exonucleases." @default.
• W2111624324 created "2016-06-24" @default.
• W2111624324 creator A5010022024 @default.
• W2111624324 creator A5019312718 @default.
• W2111624324 creator A5048662299 @default.
• W2111624324 creator A5049057337 @default.
• W2111624324 creator A5083640058 @default.
• W2111624324 creator A5087279522 @default.
• W2111624324 date "2000-08-01" @default.
• W2111624324 modified "2023-10-11" @default.
• W2111624324 title "Precursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding" @default.
• W2111624324 cites W109701900 @default.
• W2111624324 cites W121760491 @default.
• W2111624324 cites W1478195885 @default.
• W2111624324 cites W1506119659 @default.
• W2111624324 cites W1546922418 @default.
• W2111624324 cites W1554364726 @default.
• W2111624324 cites W1555326244 @default.
• W2111624324 cites W1560448233 @default.
• W2111624324 cites W1565721167 @default.
• W2111624324 cites W1833943928 @default.
• W2111624324 cites W1844218649 @default.
• W2111624324 cites W1846812271 @default.
• W2111624324 cites W1971844671 @default.
• W2111624324 cites W1976732266 @default.
• W2111624324 cites W1983283646 @default.
• W2111624324 cites W1987037348 @default.
• W2111624324 cites W1993806599 @default.
• W2111624324 cites W1997017839 @default.
• W2111624324 cites W1997279341 @default.
• W2111624324 cites W2000293147 @default.
• W2111624324 cites W2003213264 @default.
• W2111624324 cites W2013260687 @default.
• W2111624324 cites W2026908887 @default.
• W2111624324 cites W2035792284 @default.
• W2111624324 cites W2041703851 @default.
• W2111624324 cites W2044386270 @default.
• W2111624324 cites W2048095268 @default.
• W2111624324 cites W2061437690 @default.
• W2111624324 cites W2072927794 @default.
• W2111624324 cites W2073688200 @default.
• W2111624324 cites W2079255995 @default.
• W2111624324 cites W2080408951 @default.
• W2111624324 cites W2082658854 @default.
• W2111624324 cites W2086660631 @default.
• W2111624324 cites W2095676095 @default.
• W2111624324 cites W2096155896 @default.
• W2111624324 cites W2098804795 @default.
• W2111624324 cites W2099158977 @default.
• W2111624324 cites W2100269820 @default.
• W2111624324 cites W2108297093 @default.
• W2111624324 cites W2113039663 @default.
• W2111624324 cites W2113263393 @default.
• W2111624324 cites W2120959840 @default.
• W2111624324 cites W2129232563 @default.
• W2111624324 cites W2134725862 @default.
• W2111624324 cites W2135273573 @default.
• W2111624324 cites W2138022978 @default.
• W2111624324 cites W2142351060 @default.
• W2111624324 cites W2146393576 @default.
• W2111624324 cites W2157099873 @default.
• W2111624324 cites W2163636525 @default.
• W2111624324 cites W2166047139 @default.
• W2111624324 cites W2167752412 @default.
• W2111624324 cites W2168587596 @default.
• W2111624324 cites W2226932894 @default.
• W2111624324 cites W294261761 @default.
• W2111624324 cites W308486584 @default.
• W2111624324 doi "https://doi.org/10.1128/mcb.20.15.5415-5424.2000" @default.
• W2111624324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/85993" @default.
• W2111624324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10891482" @default.
• W2111624324 hasPublicationYear "2000" @default.
• W2111624324 type Work @default.
• W2111624324 sameAs 2111624324 @default.
• W2111624324 citedByCount "128" @default.
• W2111624324 countsByYear W21116243242012 @default.
• W2111624324 countsByYear W21116243242013 @default.
• W2111624324 countsByYear W21116243242014 @default.
• W2111624324 countsByYear W21116243242015 @default.
• W2111624324 countsByYear W21116243242016 @default.
• W2111624324 countsByYear W21116243242017 @default.
• W2111624324 countsByYear W21116243242018 @default.
• W2111624324 countsByYear W21116243242019 @default.
• W2111624324 countsByYear W21116243242020 @default.
• W2111624324 countsByYear W21116243242021 @default.
• W2111624324 countsByYear W21116243242022 @default.
• W2111624324 countsByYear W21116243242023 @default.
• W2111624324 crossrefType "journal-article" @default.
• W2111624324 hasAuthorship W2111624324A5010022024 @default.
• W2111624324 hasAuthorship W2111624324A5019312718 @default.
• W2111624324 hasAuthorship W2111624324A5048662299 @default.
• W2111624324 hasAuthorship W2111624324A5049057337 @default.
• W2111624324 hasAuthorship W2111624324A5083640058 @default.
• W2111624324 hasAuthorship W2111624324A5087279522 @default.
• W2111624324 hasBestOaLocation W21116243242 @default.
• W2111624324 hasConcept C104317684 @default.
• W2111624324 hasConcept C107824862 @default.
• W2111624324 hasConcept C153911025 @default.

• next