Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111628412> ?p ?o ?g. }
- W2111628412 endingPage "555" @default.
- W2111628412 startingPage "545" @default.
- W2111628412 abstract "The sheep is a valuable model in which to study GH neuroregulation as its pattern of GH secretion is very close to that in humans. Furthermore, important differences in somatostatin (SRIH) action between rats and sheep have been found previously. Our goal was to compare in male rat and ram pituitaries the binding characteristics of somatostatin receptors and the effect of SRIH and 17 analogues on GH release. Using radioautography, SRIH binding was seen to be evenly distributed over the anterior pituitary of both species. In the binding assay, binding sites were three times more concentrated in rats than in sheep. Important interspecies differences in the action of SRIH and its analogues were found: they inhibited GH at lower concentrations in rats than in sheep. Seven peptides displayed greater inhibitory ability in sheep than in rats while three were more potent in rats. Agonistic potencies to inhibit GH release in rats were correlated with somatostatin receptors subtype 2 (sst2) affinities. Our data confirm and extend the quantitative differences between rat and sheep in SRIH inhibitory action on GH secretion and confirm that ligand-binding properties of a given receptor subtype cannot be extrapolated across species." @default.
- W2111628412 created "2016-06-24" @default.
- W2111628412 creator A5014399685 @default.
- W2111628412 creator A5021175312 @default.
- W2111628412 creator A5025893905 @default.
- W2111628412 creator A5041470015 @default.
- W2111628412 creator A5051424435 @default.
- W2111628412 creator A5089989719 @default.
- W2111628412 date "1997-11-01" @default.
- W2111628412 modified "2023-10-18" @default.
- W2111628412 title "Species differences between male rat and ram pituitary somatostatin receptors involved in the inhibition of growth hormone secretion" @default.
- W2111628412 cites W1479999619 @default.
- W2111628412 cites W1559045450 @default.
- W2111628412 cites W1606588479 @default.
- W2111628412 cites W1610595749 @default.
- W2111628412 cites W1887163060 @default.
- W2111628412 cites W1914040722 @default.
- W2111628412 cites W1937350043 @default.
- W2111628412 cites W1947952978 @default.
- W2111628412 cites W1963498145 @default.
- W2111628412 cites W1972789318 @default.
- W2111628412 cites W1978322606 @default.
- W2111628412 cites W1981326638 @default.
- W2111628412 cites W1985189889 @default.
- W2111628412 cites W1985963087 @default.
- W2111628412 cites W1990809860 @default.
- W2111628412 cites W1992284590 @default.
- W2111628412 cites W1994794562 @default.
- W2111628412 cites W1995027065 @default.
- W2111628412 cites W1999968522 @default.
- W2111628412 cites W2005821299 @default.
- W2111628412 cites W2006222114 @default.
- W2111628412 cites W2008862835 @default.
- W2111628412 cites W2009168232 @default.
- W2111628412 cites W2011696525 @default.
- W2111628412 cites W2028792535 @default.
- W2111628412 cites W2030406095 @default.
- W2111628412 cites W2032515982 @default.
- W2111628412 cites W2048462736 @default.
- W2111628412 cites W2048475975 @default.
- W2111628412 cites W2058484249 @default.
- W2111628412 cites W2064159433 @default.
- W2111628412 cites W2071310612 @default.
- W2111628412 cites W2071957018 @default.
- W2111628412 cites W2072360771 @default.
- W2111628412 cites W2073140573 @default.
- W2111628412 cites W2073466411 @default.
- W2111628412 cites W2075317954 @default.
- W2111628412 cites W2078169573 @default.
- W2111628412 cites W2078245784 @default.
- W2111628412 cites W2083121455 @default.
- W2111628412 cites W2084087648 @default.
- W2111628412 cites W2087574577 @default.
- W2111628412 cites W2089845502 @default.
- W2111628412 cites W2095312317 @default.
- W2111628412 cites W2095414133 @default.
- W2111628412 cites W2103233430 @default.
- W2111628412 cites W2124330263 @default.
- W2111628412 cites W2145988372 @default.
- W2111628412 cites W2285558387 @default.
- W2111628412 cites W2398993657 @default.
- W2111628412 cites W2420898231 @default.
- W2111628412 cites W2430852836 @default.
- W2111628412 cites W2530471196 @default.
- W2111628412 doi "https://doi.org/10.1530/eje.0.1370545" @default.
- W2111628412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9405036" @default.
- W2111628412 hasPublicationYear "1997" @default.
- W2111628412 type Work @default.
- W2111628412 sameAs 2111628412 @default.
- W2111628412 citedByCount "16" @default.
- W2111628412 countsByYear W21116284122013 @default.
- W2111628412 countsByYear W21116284122018 @default.
- W2111628412 crossrefType "journal-article" @default.
- W2111628412 hasAuthorship W2111628412A5014399685 @default.
- W2111628412 hasAuthorship W2111628412A5021175312 @default.
- W2111628412 hasAuthorship W2111628412A5025893905 @default.
- W2111628412 hasAuthorship W2111628412A5041470015 @default.
- W2111628412 hasAuthorship W2111628412A5051424435 @default.
- W2111628412 hasAuthorship W2111628412A5089989719 @default.
- W2111628412 hasConcept C126322002 @default.
- W2111628412 hasConcept C134018914 @default.
- W2111628412 hasConcept C150008808 @default.
- W2111628412 hasConcept C170493617 @default.
- W2111628412 hasConcept C202751555 @default.
- W2111628412 hasConcept C2776120743 @default.
- W2111628412 hasConcept C2776297358 @default.
- W2111628412 hasConcept C2777658017 @default.
- W2111628412 hasConcept C2779029589 @default.
- W2111628412 hasConcept C49039625 @default.
- W2111628412 hasConcept C55493867 @default.
- W2111628412 hasConcept C71315377 @default.
- W2111628412 hasConcept C71924100 @default.
- W2111628412 hasConcept C80115893 @default.
- W2111628412 hasConcept C86803240 @default.
- W2111628412 hasConceptScore W2111628412C126322002 @default.
- W2111628412 hasConceptScore W2111628412C134018914 @default.
- W2111628412 hasConceptScore W2111628412C150008808 @default.
- W2111628412 hasConceptScore W2111628412C170493617 @default.