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- W2111636106 abstract "The cardioprotective actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognized within-population heterogeneity in response to FO, the etiology of which is poorly understood. Genetic variation may influence responsiveness. Here we review the available literature relating to gene variants shown to influence tissue LC n-3 PUFA status and response to FO intervention. From this review we conclude that the available evidence is relatively limited. A number of individual genotype × LC-n3 PUFA × phenotype associations have been described, but few have been investigated in subsequent cohorts or confirmed in independent studies. In the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations." @default.
- W2111636106 created "2016-06-24" @default.
- W2111636106 creator A5007388732 @default.
- W2111636106 creator A5021390459 @default.
- W2111636106 creator A5026811500 @default.
- W2111636106 creator A5031342188 @default.
- W2111636106 creator A5032748020 @default.
- W2111636106 creator A5074645101 @default.
- W2111636106 creator A5077358364 @default.
- W2111636106 creator A5082408868 @default.
- W2111636106 date "2011-08-21" @default.
- W2111636106 modified "2023-10-05" @default.
- W2111636106 title "The Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes" @default.
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