FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111640802> ?p ?o ?g. }

• W2111640802 endingPage "8" @default.
• W2111640802 startingPage "2163" @default.
• W2111640802 abstract "We have shown previously that the pathways leading to Fas-mediated apoptosis in prostatic carcinoma cell lines are intact, because apoptosis can be triggered either by Fas ligation alone in the Fas-sensitive cell lines PC3 and ALVA31 or by rendering the Fas-resistant cell lines DU145 and JCA1 Fas-sensitive by combined treatment with anti-Fas monoclonal antibody and cycloheximide (O. W. Rokhlin et al., Cancer Res., 57: 1758-1768, 1997). In this study, we demonstrate that two of the early events after Fas ligation are the release of cytochrome c from the mitochondria and activation of caspase-9. We also found that Bid is processed after Fas ligation and thus might activate the mitochondria-dependent apoptotic cascade. In a cell-free system, cytochrome c induced caspase-3-like activity in cytoplasmic extracts from all four cell lines studied, although differences in the level of enzymatic activity were observed. Western blot analysis revealed that caspase-7 is activated by cytochrome c at the same level in all extracts, whereas expression and activation of caspase-3 varied considerably. Cytochrome c-activated extracts displayed different abilities in the induction of apoptotic features in isolated nuclei such as morphological changes and DNA fragmentation. However, differences in nuclear apoptotic activity induced by cytochrome c did not correlate with the level of caspase-3 like activity in the different extracts. These results suggest that the mitochondrial pathway is involved in Fas-mediated apoptosis in prostatic carcinoma cell lines and that, in addition to caspase-7 and caspase-3, there are other factors that confer nuclear apoptotic activity." @default.
• W2111640802 created "2016-06-24" @default.
• W2111640802 creator A5013326292 @default.
• W2111640802 creator A5045503018 @default.
• W2111640802 creator A5067868393 @default.
• W2111640802 date "2000-04-15" @default.
• W2111640802 modified "2023-09-23" @default.
• W2111640802 title "Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines." @default.
• W2111640802 cites W1495853289 @default.
• W2111640802 cites W1515170822 @default.
• W2111640802 cites W1520312048 @default.
• W2111640802 cites W1560288081 @default.
• W2111640802 cites W1560483654 @default.
• W2111640802 cites W1581622491 @default.
• W2111640802 cites W1673314361 @default.
• W2111640802 cites W1787730444 @default.
• W2111640802 cites W1845459216 @default.
• W2111640802 cites W1971710333 @default.
• W2111640802 cites W1973109581 @default.
• W2111640802 cites W1976692354 @default.
• W2111640802 cites W1979995768 @default.
• W2111640802 cites W1984049955 @default.
• W2111640802 cites W1984696190 @default.
• W2111640802 cites W1985731963 @default.
• W2111640802 cites W1987407537 @default.
• W2111640802 cites W1997005484 @default.
• W2111640802 cites W2002503549 @default.
• W2111640802 cites W2012173926 @default.
• W2111640802 cites W2022393030 @default.
• W2111640802 cites W2025128734 @default.
• W2111640802 cites W2025559703 @default.
• W2111640802 cites W2030892254 @default.
• W2111640802 cites W2040852036 @default.
• W2111640802 cites W2041466047 @default.
• W2111640802 cites W2045560618 @default.
• W2111640802 cites W2062853648 @default.
• W2111640802 cites W2071012018 @default.
• W2111640802 cites W2076807689 @default.
• W2111640802 cites W2087450028 @default.
• W2111640802 cites W2089323919 @default.
• W2111640802 cites W2095578202 @default.
• W2111640802 cites W2096065245 @default.
• W2111640802 cites W2104713798 @default.
• W2111640802 cites W2107468514 @default.
• W2111640802 cites W2109334068 @default.
• W2111640802 cites W2113999599 @default.
• W2111640802 cites W2119683782 @default.
• W2111640802 cites W2140285382 @default.
• W2111640802 cites W2142301272 @default.
• W2111640802 cites W2144701362 @default.
• W2111640802 cites W2149967205 @default.
• W2111640802 cites W2159650080 @default.
• W2111640802 cites W2318612270 @default.
• W2111640802 cites W68610681 @default.
• W2111640802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10786680" @default.
• W2111640802 hasPublicationYear "2000" @default.
• W2111640802 type Work @default.
• W2111640802 sameAs 2111640802 @default.
• W2111640802 citedByCount "15" @default.
• W2111640802 crossrefType "journal-article" @default.
• W2111640802 hasAuthorship W2111640802A5013326292 @default.
• W2111640802 hasAuthorship W2111640802A5045503018 @default.
• W2111640802 hasAuthorship W2111640802A5067868393 @default.
• W2111640802 hasConcept C121608353 @default.
• W2111640802 hasConcept C153911025 @default.
• W2111640802 hasConcept C185592680 @default.
• W2111640802 hasConcept C190283241 @default.
• W2111640802 hasConcept C2776438761 @default.
• W2111640802 hasConcept C2779723316 @default.
• W2111640802 hasConcept C28859421 @default.
• W2111640802 hasConcept C29311851 @default.
• W2111640802 hasConcept C31573885 @default.
• W2111640802 hasConcept C43759708 @default.
• W2111640802 hasConcept C48297814 @default.
• W2111640802 hasConcept C54355233 @default.
• W2111640802 hasConcept C55493867 @default.
• W2111640802 hasConcept C66008609 @default.
• W2111640802 hasConcept C81885089 @default.
• W2111640802 hasConcept C86803240 @default.
• W2111640802 hasConcept C87439868 @default.
• W2111640802 hasConcept C95444343 @default.
• W2111640802 hasConcept C96232424 @default.
• W2111640802 hasConcept C98424977 @default.
• W2111640802 hasConceptScore W2111640802C121608353 @default.
• W2111640802 hasConceptScore W2111640802C153911025 @default.
• W2111640802 hasConceptScore W2111640802C185592680 @default.
• W2111640802 hasConceptScore W2111640802C190283241 @default.
• W2111640802 hasConceptScore W2111640802C2776438761 @default.
• W2111640802 hasConceptScore W2111640802C2779723316 @default.
• W2111640802 hasConceptScore W2111640802C28859421 @default.
• W2111640802 hasConceptScore W2111640802C29311851 @default.
• W2111640802 hasConceptScore W2111640802C31573885 @default.
• W2111640802 hasConceptScore W2111640802C43759708 @default.
• W2111640802 hasConceptScore W2111640802C48297814 @default.
• W2111640802 hasConceptScore W2111640802C54355233 @default.
• W2111640802 hasConceptScore W2111640802C55493867 @default.
• W2111640802 hasConceptScore W2111640802C66008609 @default.
• W2111640802 hasConceptScore W2111640802C81885089 @default.

• next