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- W2111651979 abstract "SPECIFIC AIMSIn this study we sought to dissect the domains of apoE required for cholesterol and triglyceride homeostasis in vivo using adenovirus-mediated gene transfer in apoE-deficient (E−/−) mice. Mice were infected with replication-deficient recombinant adenoviruses expressing the full-length apoE4 or the truncated apoE4–229 and apoE4–259 forms containing the amino acids 1–229 and 1–259, respectively. The ability of the amino- and carboxyl-terminal regions of apoE to associate with lipoproteins and promote receptor-mediated cholesterol clearance or cholesterol and triglyceride accumulation was assessed. Mechanisms were sought to explain the apoE-mediated cholesterol and triglyceride clearance by the truncated apoE forms and the apoE-induced hypertriglyceridemia by the full-length apoE.PRINCIPAL FINDINGS1. The full-length apoE4 and the truncated apoE forms apoE4–229 and apoE4–259 are secreted efficiently by cells and associate similarly with VLDL particlesHTB-13 cells that do not synthesize endogenous..." @default.
- W2111651979 created "2016-06-24" @default.
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- W2111651979 date "2001-05-18" @default.
- W2111651979 modified "2023-09-28" @default.
- W2111651979 title "Analysis of the structure and function relationship of human apolipoprotein E in vivo, using adenovirus‐mediated gene transfer" @default.
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- W2111651979 doi "https://doi.org/10.1096/fj.00-0882fje" @default.
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