Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111665712> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2111665712 endingPage "525" @default.
- W2111665712 startingPage "523" @default.
- W2111665712 abstract "Combined spinal epidural anesthesia has become increasingly popular as a method of providing rapid onset of analgesia or surgical block with access for further administration of analgesics or anesthetics.No in vivo studies have evaluated the relationship between dural puncture and drug transfer from the epidural space to the cerebrospinal fluid (CSF). To determine whether morphine administered in the epidural space adjacent to a dural puncture results in increased CSF concentrations at the cisterna magna (CM), 12 adult ewes were studied. Each animal was assigned to one of three groups. Animals in Group 1 served as a control and received no dural puncture. Animals in Group 2 received a dural puncture with a 25-gauge (G) Whitacre needle, while Group 3 animals received a dural puncture with an 18-G Tuohy needle. One hour after dural puncture, each animal was given epidural morphine, 0.2 mg/kg. Six hours after the administration of epidural morphine, CSF from the CM was sampled and analyzed by gas chromatographymass spectrometry for morphine concentration. The mean morphine concentration at the CM for Group 1 (control) was 22 +/- 12 ng/mL, whereas animals with 25-G and 18-G dural punctures had concentrations of 154 +/- 32 ng/mL and 405 +/- 53 ng/mL, respectively (P = 0.0005). These data demonstrate that a significant increase in CSF morphine concentration at the brainstem will occur when lumbar epidural morphine is administered adjacent to a dural puncture. Furthermore, the increase in CSF morphine concentration is positively correlated with the size of the needle producing the dural puncture. These findings highlight the potential for delayed respiratory depression when epidural opiate administration follows a dural puncture. (Anesth Analg 1996;83:523-5)" @default.
- W2111665712 created "2016-06-24" @default.
- W2111665712 creator A5020675924 @default.
- W2111665712 creator A5031716854 @default.
- W2111665712 creator A5038019657 @default.
- W2111665712 creator A5042694224 @default.
- W2111665712 creator A5090633462 @default.
- W2111665712 date "1996-09-01" @default.
- W2111665712 modified "2023-10-14" @default.
- W2111665712 title "The Effect of Prior Dural Puncture on Cisternal Cerebrospinal Fluid Morphine Concentrations in Sheep After Administration of Lumbar Epidural Morphine" @default.
- W2111665712 cites W1964783001 @default.
- W2111665712 cites W1984940644 @default.
- W2111665712 cites W2004539241 @default.
- W2111665712 cites W2015976758 @default.
- W2111665712 cites W2025946370 @default.
- W2111665712 cites W2033249179 @default.
- W2111665712 cites W2047718156 @default.
- W2111665712 cites W2074754548 @default.
- W2111665712 cites W2110134427 @default.
- W2111665712 cites W2130680772 @default.
- W2111665712 cites W2144135350 @default.
- W2111665712 doi "https://doi.org/10.1097/00000539-199609000-00014" @default.
- W2111665712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8780274" @default.
- W2111665712 hasPublicationYear "1996" @default.
- W2111665712 type Work @default.
- W2111665712 sameAs 2111665712 @default.
- W2111665712 citedByCount "21" @default.
- W2111665712 countsByYear W21116657122013 @default.
- W2111665712 countsByYear W21116657122015 @default.
- W2111665712 countsByYear W21116657122018 @default.
- W2111665712 countsByYear W21116657122022 @default.
- W2111665712 countsByYear W21116657122023 @default.
- W2111665712 crossrefType "journal-article" @default.
- W2111665712 hasAuthorship W2111665712A5020675924 @default.
- W2111665712 hasAuthorship W2111665712A5031716854 @default.
- W2111665712 hasAuthorship W2111665712A5038019657 @default.
- W2111665712 hasAuthorship W2111665712A5042694224 @default.
- W2111665712 hasAuthorship W2111665712A5090633462 @default.
- W2111665712 hasBestOaLocation W21116657121 @default.
- W2111665712 hasConcept C126322002 @default.
- W2111665712 hasConcept C141071460 @default.
- W2111665712 hasConcept C2776651062 @default.
- W2111665712 hasConcept C2777276199 @default.
- W2111665712 hasConcept C2777389121 @default.
- W2111665712 hasConcept C2777439173 @default.
- W2111665712 hasConcept C2777610700 @default.
- W2111665712 hasConcept C2777657843 @default.
- W2111665712 hasConcept C2778200158 @default.
- W2111665712 hasConcept C2778987889 @default.
- W2111665712 hasConcept C2779651940 @default.
- W2111665712 hasConcept C2780066322 @default.
- W2111665712 hasConcept C2780813298 @default.
- W2111665712 hasConcept C2781072394 @default.
- W2111665712 hasConcept C2781328992 @default.
- W2111665712 hasConcept C2992886682 @default.
- W2111665712 hasConcept C42219234 @default.
- W2111665712 hasConcept C44575665 @default.
- W2111665712 hasConcept C71924100 @default.
- W2111665712 hasConceptScore W2111665712C126322002 @default.
- W2111665712 hasConceptScore W2111665712C141071460 @default.
- W2111665712 hasConceptScore W2111665712C2776651062 @default.
- W2111665712 hasConceptScore W2111665712C2777276199 @default.
- W2111665712 hasConceptScore W2111665712C2777389121 @default.
- W2111665712 hasConceptScore W2111665712C2777439173 @default.
- W2111665712 hasConceptScore W2111665712C2777610700 @default.
- W2111665712 hasConceptScore W2111665712C2777657843 @default.
- W2111665712 hasConceptScore W2111665712C2778200158 @default.
- W2111665712 hasConceptScore W2111665712C2778987889 @default.
- W2111665712 hasConceptScore W2111665712C2779651940 @default.
- W2111665712 hasConceptScore W2111665712C2780066322 @default.
- W2111665712 hasConceptScore W2111665712C2780813298 @default.
- W2111665712 hasConceptScore W2111665712C2781072394 @default.
- W2111665712 hasConceptScore W2111665712C2781328992 @default.
- W2111665712 hasConceptScore W2111665712C2992886682 @default.
- W2111665712 hasConceptScore W2111665712C42219234 @default.
- W2111665712 hasConceptScore W2111665712C44575665 @default.
- W2111665712 hasConceptScore W2111665712C71924100 @default.
- W2111665712 hasIssue "3" @default.
- W2111665712 hasLocation W21116657121 @default.
- W2111665712 hasLocation W21116657122 @default.
- W2111665712 hasLocation W21116657123 @default.
- W2111665712 hasOpenAccess W2111665712 @default.
- W2111665712 hasPrimaryLocation W21116657121 @default.
- W2111665712 hasRelatedWork W1985713820 @default.
- W2111665712 hasRelatedWork W2033114469 @default.
- W2111665712 hasRelatedWork W2050622133 @default.
- W2111665712 hasRelatedWork W2089122869 @default.
- W2111665712 hasRelatedWork W2111665712 @default.
- W2111665712 hasRelatedWork W2408217943 @default.
- W2111665712 hasRelatedWork W2410843395 @default.
- W2111665712 hasRelatedWork W2412652040 @default.
- W2111665712 hasRelatedWork W4310779666 @default.
- W2111665712 hasRelatedWork W4313292159 @default.
- W2111665712 hasVolume "83" @default.
- W2111665712 isParatext "false" @default.
- W2111665712 isRetracted "false" @default.
- W2111665712 magId "2111665712" @default.
- W2111665712 workType "article" @default.