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• W2111671622 abstract "In a randomised double-blind trial, postoperative analgesia and side effects of intrathecal morphine 0.1mg and intrathecal diamorphine 0.25mg were compared. Sixty women were randomised to receive intrathecal injection of 12.5mg hyperbaric bupivacaine and 12.5μg fentanyl with either morphine 0.1mg (group M), or diamorphine 0.25mg (group D). All women received 100mg diclofenac rectally at the end of surgery and were given intravenous morphine via a patient controlled analgesia (PCA) system. Pain, PCA morphine usage and side effects were assessed at 2, 4, 8 and 24h after spinal anaesthesia. The two groups were comparable for quality of intraoperative analgesia. There were no significant differences between the groups in time to first PCA demand, morphine consumption or oral analgesic use in each time period. Significantly more patients in group M were nauseated at 4h whilst at 24h nausea was significantly worse in group D. There was no significant difference between the groups in the number of women vomiting in the 24-h period. The two groups were comparable for pruritus and drowsiness. We conclude that 0.25mg subarachnoid diamorphine is a suitable alternative to 0.1mg morphine for post caesarean section analgesia." @default.
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• W2111671622 date "2001-01-01" @default.
• W2111671622 modified "2023-10-11" @default.
• W2111671622 title "A comparison of bupivacaine-fentanyl-morphine with bupivacaine-fentanyl-diamorphine for caesarean section under spinal anaesthesia" @default.
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• W2111671622 doi "https://doi.org/10.1054/ijoa.2000.0718" @default.
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