Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111676557> ?p ?o ?g. }
- W2111676557 endingPage "226" @default.
- W2111676557 startingPage "219" @default.
- W2111676557 abstract "l-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H2O2), were characterized with lower levels of l-carnitine, diminished β-oxidation, and increased lipid accumulation compared to the controls. γ-Butyrobetainealdehyde dehydrogenase (BADH) and butyrobetaine dioxygenase (BBDOX), two key enzymes mediating the biogenesis of l-carnitine, were sharply reduced during Al and H2O2 challenge. Exposure of the Al and H2O2-treated cells to α-ketoglutarate (KG), led to the recovery of l-carnitine production with the concomitant reduction in ROS levels. It appears that the channeling of KG to combat oxidative stress results in decreased l-carnitine synthesis, an event that contributes to the dyslipidemia observed during Al and H2O2 insults in these mammalian cells. Hence, KG may help alleviate pathological conditions induced by oxidative stress." @default.
- W2111676557 created "2016-06-24" @default.
- W2111676557 creator A5025839843 @default.
- W2111676557 creator A5043222849 @default.
- W2111676557 creator A5049642674 @default.
- W2111676557 creator A5061668188 @default.
- W2111676557 creator A5075688945 @default.
- W2111676557 date "2011-06-01" @default.
- W2111676557 modified "2023-09-24" @default.
- W2111676557 title "The disruption of l-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells" @default.
- W2111676557 cites W1504584187 @default.
- W2111676557 cites W1971001121 @default.
- W2111676557 cites W1987400910 @default.
- W2111676557 cites W1995039474 @default.
- W2111676557 cites W2000656455 @default.
- W2111676557 cites W2000855005 @default.
- W2111676557 cites W2001003591 @default.
- W2111676557 cites W2008192418 @default.
- W2111676557 cites W2012452082 @default.
- W2111676557 cites W2012743472 @default.
- W2111676557 cites W2014964091 @default.
- W2111676557 cites W2019763508 @default.
- W2111676557 cites W2026485676 @default.
- W2111676557 cites W2027944706 @default.
- W2111676557 cites W2033224797 @default.
- W2111676557 cites W2035020078 @default.
- W2111676557 cites W2041986513 @default.
- W2111676557 cites W2042370745 @default.
- W2111676557 cites W2047399032 @default.
- W2111676557 cites W2047806866 @default.
- W2111676557 cites W2057199368 @default.
- W2111676557 cites W2061850933 @default.
- W2111676557 cites W2063371766 @default.
- W2111676557 cites W2067669340 @default.
- W2111676557 cites W2073909404 @default.
- W2111676557 cites W2080451545 @default.
- W2111676557 cites W2085101416 @default.
- W2111676557 cites W2086018024 @default.
- W2111676557 cites W2097412342 @default.
- W2111676557 cites W2099342129 @default.
- W2111676557 cites W2100837269 @default.
- W2111676557 cites W2114328455 @default.
- W2111676557 cites W2117009957 @default.
- W2111676557 cites W2119065814 @default.
- W2111676557 cites W2120778027 @default.
- W2111676557 cites W2131718574 @default.
- W2111676557 cites W2137007705 @default.
- W2111676557 cites W2143345065 @default.
- W2111676557 cites W2157870298 @default.
- W2111676557 cites W2160196085 @default.
- W2111676557 cites W2165205224 @default.
- W2111676557 cites W2167914348 @default.
- W2111676557 cites W2285946151 @default.
- W2111676557 cites W2575789697 @default.
- W2111676557 cites W4236791864 @default.
- W2111676557 cites W4293247451 @default.
- W2111676557 cites W53384153 @default.
- W2111676557 doi "https://doi.org/10.1016/j.toxlet.2011.03.019" @default.
- W2111676557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21439360" @default.
- W2111676557 hasPublicationYear "2011" @default.
- W2111676557 type Work @default.
- W2111676557 sameAs 2111676557 @default.
- W2111676557 citedByCount "38" @default.
- W2111676557 countsByYear W21116765572012 @default.
- W2111676557 countsByYear W21116765572013 @default.
- W2111676557 countsByYear W21116765572014 @default.
- W2111676557 countsByYear W21116765572015 @default.
- W2111676557 countsByYear W21116765572016 @default.
- W2111676557 countsByYear W21116765572017 @default.
- W2111676557 countsByYear W21116765572018 @default.
- W2111676557 countsByYear W21116765572019 @default.
- W2111676557 countsByYear W21116765572020 @default.
- W2111676557 countsByYear W21116765572021 @default.
- W2111676557 countsByYear W21116765572022 @default.
- W2111676557 countsByYear W21116765572023 @default.
- W2111676557 crossrefType "journal-article" @default.
- W2111676557 hasAuthorship W2111676557A5025839843 @default.
- W2111676557 hasAuthorship W2111676557A5043222849 @default.
- W2111676557 hasAuthorship W2111676557A5049642674 @default.
- W2111676557 hasAuthorship W2111676557A5061668188 @default.
- W2111676557 hasAuthorship W2111676557A5075688945 @default.
- W2111676557 hasConcept C134018914 @default.
- W2111676557 hasConcept C185592680 @default.
- W2111676557 hasConcept C2776151105 @default.
- W2111676557 hasConcept C2777477808 @default.
- W2111676557 hasConcept C2778096610 @default.
- W2111676557 hasConcept C2778435403 @default.
- W2111676557 hasConcept C28859421 @default.
- W2111676557 hasConcept C4733338 @default.
- W2111676557 hasConcept C511355011 @default.
- W2111676557 hasConcept C55493867 @default.
- W2111676557 hasConcept C62231903 @default.
- W2111676557 hasConcept C86803240 @default.
- W2111676557 hasConceptScore W2111676557C134018914 @default.
- W2111676557 hasConceptScore W2111676557C185592680 @default.
- W2111676557 hasConceptScore W2111676557C2776151105 @default.
- W2111676557 hasConceptScore W2111676557C2777477808 @default.
- W2111676557 hasConceptScore W2111676557C2778096610 @default.