FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111680106> ?p ?o ?g. }

• W2111680106 endingPage "E390" @default.
• W2111680106 startingPage "E380" @default.
• W2111680106 abstract "Genetic ablation of the voltage-gated potassium channel Kv1.3 improves insulin sensitivity and increases metabolic rate in mice. Inhibition of Kv1.3 in mouse adipose and skeletal muscle is reported to increase glucose uptake through increased GLUT4 translocation. Since Kv1.3 represents a novel target for the treatment of diabetes, the present study investigated whether Kv1.3 is functionally expressed in human adipose and skeletal muscle and whether specific pharmacological inhibition of the channel is capable of modulating insulin sensitivity in diabetic mouse models. Voltage-gated K(+) channel currents in human skeletal muscle cells (SkMC) were insensitive to block by the specific Kv1.3 blockers 5-(4-phenoxybutoxy)psoralen (PAP-1) and margatoxin (MgTX). Glucose uptake into SkMC and mouse 3T3-L1 adipocytes was also unaffected by treatment with PAP-1 or MgTX. Kv1.3 protein expression was not observed in human adipose or skeletal muscle from normal and type 2 diabetic donors. To investigate the effect of specific Kv1.3 inhibition on insulin sensitivity in vivo, PAP-1 was administered to hyperglycemic mice either acutely or for 5 days prior to an insulin tolerance test. No effect on insulin sensitivity was observed at free plasma PAP-1 concentrations that are specific for inhibition of Kv1.3. Insulin sensitivity was increased only when plasma concentrations of PAP-1 were sufficient to inhibit other Kv1 channels. Surprisingly, acute inhibition of Kv1.3 in the brain was found to decrease insulin sensitivity in ob/ob mice. Overall, these findings are not supportive of a role for Kv1.3 in the modulation of peripheral insulin sensitivity." @default.
• W2111680106 created "2016-06-24" @default.
• W2111680106 creator A5010997723 @default.
• W2111680106 creator A5035707714 @default.
• W2111680106 creator A5040886856 @default.
• W2111680106 creator A5044189350 @default.
• W2111680106 creator A5059089763 @default.
• W2111680106 creator A5072259679 @default.
• W2111680106 creator A5072536907 @default.
• W2111680106 creator A5078948939 @default.
• W2111680106 creator A5086898961 @default.
• W2111680106 date "2011-08-01" @default.
• W2111680106 modified "2023-09-26" @default.
• W2111680106 title "Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues" @default.
• W2111680106 cites W1492144011 @default.
• W2111680106 cites W1558096813 @default.
• W2111680106 cites W1849908979 @default.
• W2111680106 cites W1965832750 @default.
• W2111680106 cites W1979915354 @default.
• W2111680106 cites W1981962083 @default.
• W2111680106 cites W1985326573 @default.
• W2111680106 cites W1994038676 @default.
• W2111680106 cites W2003197155 @default.
• W2111680106 cites W2009818179 @default.
• W2111680106 cites W2012650768 @default.
• W2111680106 cites W2019310318 @default.
• W2111680106 cites W2026075483 @default.
• W2111680106 cites W2036209063 @default.
• W2111680106 cites W2041016185 @default.
• W2111680106 cites W2049548746 @default.
• W2111680106 cites W2065897200 @default.
• W2111680106 cites W2067249361 @default.
• W2111680106 cites W2086256855 @default.
• W2111680106 cites W2099587101 @default.
• W2111680106 cites W2118593499 @default.
• W2111680106 cites W2120568978 @default.
• W2111680106 cites W2125974686 @default.
• W2111680106 cites W2133943699 @default.
• W2111680106 cites W2165727470 @default.
• W2111680106 cites W2170987244 @default.
• W2111680106 cites W4238497443 @default.
• W2111680106 cites W4245660285 @default.
• W2111680106 cites W4249727000 @default.
• W2111680106 doi "https://doi.org/10.1152/ajpendo.00076.2011" @default.
• W2111680106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21586699" @default.
• W2111680106 hasPublicationYear "2011" @default.
• W2111680106 type Work @default.
• W2111680106 sameAs 2111680106 @default.
• W2111680106 citedByCount "14" @default.
• W2111680106 countsByYear W21116801062012 @default.
• W2111680106 countsByYear W21116801062013 @default.
• W2111680106 countsByYear W21116801062014 @default.
• W2111680106 countsByYear W21116801062015 @default.
• W2111680106 countsByYear W21116801062016 @default.
• W2111680106 countsByYear W21116801062017 @default.
• W2111680106 countsByYear W21116801062018 @default.
• W2111680106 countsByYear W21116801062023 @default.
• W2111680106 crossrefType "journal-article" @default.
• W2111680106 hasAuthorship W2111680106A5010997723 @default.
• W2111680106 hasAuthorship W2111680106A5035707714 @default.
• W2111680106 hasAuthorship W2111680106A5040886856 @default.
• W2111680106 hasAuthorship W2111680106A5044189350 @default.
• W2111680106 hasAuthorship W2111680106A5059089763 @default.
• W2111680106 hasAuthorship W2111680106A5072259679 @default.
• W2111680106 hasAuthorship W2111680106A5072536907 @default.
• W2111680106 hasAuthorship W2111680106A5078948939 @default.
• W2111680106 hasAuthorship W2111680106A5086898961 @default.
• W2111680106 hasConcept C126322002 @default.
• W2111680106 hasConcept C134018914 @default.
• W2111680106 hasConcept C150903083 @default.
• W2111680106 hasConcept C171089720 @default.
• W2111680106 hasConcept C185592680 @default.
• W2111680106 hasConcept C207001950 @default.
• W2111680106 hasConcept C2776188179 @default.
• W2111680106 hasConcept C2777180221 @default.
• W2111680106 hasConcept C2777391703 @default.
• W2111680106 hasConcept C2777866211 @default.
• W2111680106 hasConcept C2779306644 @default.
• W2111680106 hasConcept C2779959927 @default.
• W2111680106 hasConcept C3018667095 @default.
• W2111680106 hasConcept C555293320 @default.
• W2111680106 hasConcept C71924100 @default.
• W2111680106 hasConcept C83743174 @default.
• W2111680106 hasConcept C86803240 @default.
• W2111680106 hasConceptScore W2111680106C126322002 @default.
• W2111680106 hasConceptScore W2111680106C134018914 @default.
• W2111680106 hasConceptScore W2111680106C150903083 @default.
• W2111680106 hasConceptScore W2111680106C171089720 @default.
• W2111680106 hasConceptScore W2111680106C185592680 @default.
• W2111680106 hasConceptScore W2111680106C207001950 @default.
• W2111680106 hasConceptScore W2111680106C2776188179 @default.
• W2111680106 hasConceptScore W2111680106C2777180221 @default.
• W2111680106 hasConceptScore W2111680106C2777391703 @default.
• W2111680106 hasConceptScore W2111680106C2777866211 @default.
• W2111680106 hasConceptScore W2111680106C2779306644 @default.
• W2111680106 hasConceptScore W2111680106C2779959927 @default.
• W2111680106 hasConceptScore W2111680106C3018667095 @default.
• W2111680106 hasConceptScore W2111680106C555293320 @default.

• next