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- W2111689842 abstract "The synthesis and beta-lactamase inhibitory activity of four 6-(mercaptomethyl)penicillinates and the four corresponding 6-(hydroxymethyl)penicillinates are described. These penicillins include both C6 stereoisomers as well as the sulfide and sulfone oxidation states of the penam thiazolidine sulfur. All compounds were evaluated as inhibitors of representative metallo- and serine-beta-lactamases enzymes. Selected (mercaptomethyl)penicillinates are shown to inactivate both metallo- and serine-beta-lactamases and to display synergism with piperacillin against beta-lactamase producing strains." @default.
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- W2111689842 date "2004-03-01" @default.
- W2111689842 modified "2023-09-26" @default.
- W2111689842 title "Penicillin-derived inhibitors that simultaneously target both metallo- and serine-β-lactamases" @default.
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- W2111689842 doi "https://doi.org/10.1016/j.bmcl.2003.12.037" @default.
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