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• W2111692012 abstract "We aimed to investigate the probability of and time to first live birth after recurrent miscarriage (RM). A cohort study in participants of the ALIFE study1 , including follow-up of up to 10 years after randomization. Women with unexplained RM (with or without inherited thrombophilia) who participated in the ALIFE study were contacted by phone. Data on all pregnancies, including date and outcome were collected in a predefined CRF. We calculated the proportion of women from the ALIFE study who had at least one live birth since randomization at 12, 24, 36 and 48 months. The relative prognostic significance of female age (<36 vs. ≥36 years), the number of preceding miscarriages (2 vs. ≥3), a previous live birth and inherited thrombophilia was evaluated by Cox regression for time to live birth. Data were censored when participants quit trying to conceive or when pregnancy was not reached at the age of 43. Data of women who were not reached in follow up were censored based on ALIFE pregnancy data (i.e. censored at time of pregnancy loss or at end of study in case no pregnancy occurred). Follow-up data of 233 (64%) of 364 women were obtained. Seventeen women were excluded because of drop-out in the ALIFE study. Of the analyzed 347 women, 242 (69.7%) had at least 1 live birth after randomization. 197 of these live births occurred during the ALIFE study; additionally 45 women had a live birth during follow up. A total of 349 babies were born. After censoring, 140 (40.3%), 213 (61.4%), 227 (65.7%) and 233 (67.1%) of 347 women had a first live birth at 12, 24, 36 and 48 months respectively. Cox regression analysis showed a lower probability of live birth in women with ≥3 miscarriages compared to women with 2 miscarriages (HR 0.73 [95% CI 0.55-0.97]), and higher probability in women with inherited thrombophilia (HR 1.65 [95% CI 1.13 – 2.4]). An effect of potential bias due to selective loss to follow-up is uncertain as it could affect the live birth estimate in both a positive of negative manner. 69.7% of women with unexplained RM had at least one live birth. The probability of live birth was lower in women with ≥3 miscarriages and higher in women with inherited thrombophilia." @default.
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• W2111692012 date "2014-09-01" @default.
• W2111692012 modified "2023-09-27" @default.
• W2111692012 title "Live birth rate and time to live birth in women with unexplained recurrent miscarriage with or without inherited thrombophilia" @default.
• W2111692012 doi "https://doi.org/10.1016/j.fertnstert.2014.07.279" @default.
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