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- W2111699299 abstract "Opioid antagonists have been indispensable as tools in opioid research (Zimmerman and Leander 1990). In fact, the chief criterion for the classification of an agonist effect as opioid receptor-mediated is the ability of naloxone (Sawynok et al. 1979) or naltrexone (Gold et al. 1982) to reversibly antagonize this effect in a competitive fashion. The usefulness of these ligands for this purpose stems from the fact that they are universal opioid antagonists; that is, they are capable of antagonizing the agonist effects mediated by multiple opioid receptor types." @default.
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- W2111699299 date "1993-01-01" @default.
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- W2111699299 title "Selective Nonpeptide Opioid Antagonists" @default.
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