Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111704741> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2111704741 endingPage "1847" @default.
- W2111704741 startingPage "1844" @default.
- W2111704741 abstract "A significant proportion of human immunodeficiency virus (HIV) infected patients are coinfected with hepatitis B virus (HBV). Currently available treatments for chronic hepatitis B (interferon [IFN]-alpha and lamivudine [3TC]) have limited long-term utility because of side effects or of the development of resistance. Tenofovir disoproxil fumarate (TDF) is a nucleotide analog with excellent activity in vitro against HBV, which is also active against 3TC-resistant HBV variants. In this 24-week pilot study, the anti-HBV activity of TDF was prospectively evaluated in a cohort of 6 HIV coinfected subjects for whom 3TC and IFN therapy had previously failed. At baseline, all patients were taking 3TC or FTC and were hepatitis B surface antigen and hepatitis B e antigen positive; 4 had cirrhosis. Baseline HBV load was 7.95 log(10) copies/mL. By weeks 12 and 24, HBV load had decreased by 3.1 log(10) copies/mL and 4.3 log(10) copies/mL, respectively. There was a transient increase of transaminases after the initiation of treatment. No patient developed HBe antibodies. TDF is a very promising drug for the treatment of chronic hepatitis B in HIV-infected individuals." @default.
- W2111704741 created "2016-06-24" @default.
- W2111704741 creator A5006040809 @default.
- W2111704741 creator A5027623190 @default.
- W2111704741 creator A5031930130 @default.
- W2111704741 creator A5058226785 @default.
- W2111704741 creator A5061630637 @default.
- W2111704741 creator A5076519780 @default.
- W2111704741 creator A5088973456 @default.
- W2111704741 date "2002-12-15" @default.
- W2111704741 modified "2023-10-18" @default.
- W2111704741 title "Tenofovir Disoproxil Fumarate Therapy for Chronic Hepatitis B in Human Immunodeficiency Virus/Hepatitis B Virus–Coinfected Individuals for Whom Interferon‐α and Lamivudine Therapy Have Failed" @default.
- W2111704741 cites W1967634644 @default.
- W2111704741 cites W1976097884 @default.
- W2111704741 cites W2013602271 @default.
- W2111704741 cites W2022056018 @default.
- W2111704741 cites W2070341160 @default.
- W2111704741 cites W2078301083 @default.
- W2111704741 cites W2103529803 @default.
- W2111704741 cites W2111743672 @default.
- W2111704741 cites W2111934155 @default.
- W2111704741 cites W2129712640 @default.
- W2111704741 cites W2147194699 @default.
- W2111704741 cites W2156015715 @default.
- W2111704741 cites W2424806111 @default.
- W2111704741 doi "https://doi.org/10.1086/345770" @default.
- W2111704741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12447773" @default.
- W2111704741 hasPublicationYear "2002" @default.
- W2111704741 type Work @default.
- W2111704741 sameAs 2111704741 @default.
- W2111704741 citedByCount "151" @default.
- W2111704741 countsByYear W21117047412012 @default.
- W2111704741 countsByYear W21117047412013 @default.
- W2111704741 countsByYear W21117047412014 @default.
- W2111704741 countsByYear W21117047412015 @default.
- W2111704741 countsByYear W21117047412016 @default.
- W2111704741 countsByYear W21117047412017 @default.
- W2111704741 countsByYear W21117047412018 @default.
- W2111704741 countsByYear W21117047412019 @default.
- W2111704741 countsByYear W21117047412020 @default.
- W2111704741 countsByYear W21117047412021 @default.
- W2111704741 crossrefType "journal-article" @default.
- W2111704741 hasAuthorship W2111704741A5006040809 @default.
- W2111704741 hasAuthorship W2111704741A5027623190 @default.
- W2111704741 hasAuthorship W2111704741A5031930130 @default.
- W2111704741 hasAuthorship W2111704741A5058226785 @default.
- W2111704741 hasAuthorship W2111704741A5061630637 @default.
- W2111704741 hasAuthorship W2111704741A5076519780 @default.
- W2111704741 hasAuthorship W2111704741A5088973456 @default.
- W2111704741 hasBestOaLocation W21117047411 @default.
- W2111704741 hasConcept C126322002 @default.
- W2111704741 hasConcept C159047783 @default.
- W2111704741 hasConcept C203014093 @default.
- W2111704741 hasConcept C2522874641 @default.
- W2111704741 hasConcept C2776543447 @default.
- W2111704741 hasConcept C2777333352 @default.
- W2111704741 hasConcept C2777382497 @default.
- W2111704741 hasConcept C2777869810 @default.
- W2111704741 hasConcept C2780593183 @default.
- W2111704741 hasConcept C55493867 @default.
- W2111704741 hasConcept C71924100 @default.
- W2111704741 hasConcept C86803240 @default.
- W2111704741 hasConceptScore W2111704741C126322002 @default.
- W2111704741 hasConceptScore W2111704741C159047783 @default.
- W2111704741 hasConceptScore W2111704741C203014093 @default.
- W2111704741 hasConceptScore W2111704741C2522874641 @default.
- W2111704741 hasConceptScore W2111704741C2776543447 @default.
- W2111704741 hasConceptScore W2111704741C2777333352 @default.
- W2111704741 hasConceptScore W2111704741C2777382497 @default.
- W2111704741 hasConceptScore W2111704741C2777869810 @default.
- W2111704741 hasConceptScore W2111704741C2780593183 @default.
- W2111704741 hasConceptScore W2111704741C55493867 @default.
- W2111704741 hasConceptScore W2111704741C71924100 @default.
- W2111704741 hasConceptScore W2111704741C86803240 @default.
- W2111704741 hasIssue "12" @default.
- W2111704741 hasLocation W21117047411 @default.
- W2111704741 hasLocation W21117047412 @default.
- W2111704741 hasOpenAccess W2111704741 @default.
- W2111704741 hasPrimaryLocation W21117047411 @default.
- W2111704741 hasRelatedWork W2003048101 @default.
- W2111704741 hasRelatedWork W2023559661 @default.
- W2111704741 hasRelatedWork W2026023493 @default.
- W2111704741 hasRelatedWork W2057635692 @default.
- W2111704741 hasRelatedWork W2062181138 @default.
- W2111704741 hasRelatedWork W2068301221 @default.
- W2111704741 hasRelatedWork W2406326272 @default.
- W2111704741 hasRelatedWork W4234848984 @default.
- W2111704741 hasRelatedWork W2115297968 @default.
- W2111704741 hasRelatedWork W2165546505 @default.
- W2111704741 hasVolume "186" @default.
- W2111704741 isParatext "false" @default.
- W2111704741 isRetracted "false" @default.
- W2111704741 magId "2111704741" @default.
- W2111704741 workType "article" @default.