FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111715662> ?p ?o ?g. }

• W2111715662 endingPage "1945" @default.
• W2111715662 startingPage "1936" @default.
• W2111715662 abstract "Background. Despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA by antiretroviral therapy to levels below clinical assay detection, infection and immune activation may persist within the central nervous system and possibly lead to continued brain injury. We hypothesized that intensifying therapy would decrease cerebrospinal fluid (CSF) infection and immune activation. Methods. This was a 12-week, randomized, open-label pilot study comparing addition of the integrase inhibitor raltegravir to no treatment augmentation, with an option for rollover to raltegravir. CSF and plasma were analyzed for HIV-1 RNA using a single-copy assay. CSF and blood immune activation was assessed by neopterin concentrations and CD4+ and CD8+ T-cell surface antigen expression. Results. Primary analysis compared 14 intensified (including rollovers) to 9 nonintensified subject experiences. Median HIV-1 RNA levels in all samples were lower in CSF (<.3 copies/mL) than in plasma (<.9 copies/mL; P < .0001), and raltegravir did not reduce HIV-1 RNA, CSF neopterin, or CD4+ and CD8+ T-cell activation. Conclusions. Raltegravir intensification did not reduce intrathecal immunoactivation or alter CSF HIV-1 RNA levels in subjects with baseline viral suppression. With and without raltegravir intensification, HIV RNA levels in CSF were very low in the enrolled subjects. Clinical Trials Registration. NCT00672932." @default.
• W2111715662 created "2016-06-24" @default.
• W2111715662 creator A5002830154 @default.
• W2111715662 creator A5033537236 @default.
• W2111715662 creator A5071035150 @default.
• W2111715662 creator A5081156604 @default.
• W2111715662 creator A5081960485 @default.
• W2111715662 creator A5082201115 @default.
• W2111715662 creator A5082310426 @default.
• W2111715662 creator A5083290723 @default.
• W2111715662 creator A5087696147 @default.
• W2111715662 date "2011-10-21" @default.
• W2111715662 modified "2023-10-01" @default.
• W2111715662 title "Raltegravir Treatment Intensification Does Not Alter Cerebrospinal Fluid HIV-1 Infection or Immunoactivation in Subjects on Suppressive Therapy" @default.
• W2111715662 cites W1965166311 @default.
• W2111715662 cites W1965354305 @default.
• W2111715662 cites W1965760235 @default.
• W2111715662 cites W1971618906 @default.
• W2111715662 cites W1974060304 @default.
• W2111715662 cites W1981473511 @default.
• W2111715662 cites W1984034687 @default.
• W2111715662 cites W2003668208 @default.
• W2111715662 cites W2005141763 @default.
• W2111715662 cites W2007607803 @default.
• W2111715662 cites W2020566551 @default.
• W2111715662 cites W2024442062 @default.
• W2111715662 cites W2029097526 @default.
• W2111715662 cites W2045044146 @default.
• W2111715662 cites W2057261851 @default.
• W2111715662 cites W2059190492 @default.
• W2111715662 cites W2061543749 @default.
• W2111715662 cites W2063955495 @default.
• W2111715662 cites W2074276844 @default.
• W2111715662 cites W2074280442 @default.
• W2111715662 cites W2074612845 @default.
• W2111715662 cites W2087423729 @default.
• W2111715662 cites W2095000786 @default.
• W2111715662 cites W2095865673 @default.
• W2111715662 cites W2097102978 @default.
• W2111715662 cites W2099636218 @default.
• W2111715662 cites W2103552592 @default.
• W2111715662 cites W2104741590 @default.
• W2111715662 cites W2109010689 @default.
• W2111715662 cites W2113669930 @default.
• W2111715662 cites W2114994968 @default.
• W2111715662 cites W2115118763 @default.
• W2111715662 cites W2115221693 @default.
• W2111715662 cites W2117962018 @default.
• W2111715662 cites W2119974226 @default.
• W2111715662 cites W2120653113 @default.
• W2111715662 cites W2127069469 @default.
• W2111715662 cites W2129626693 @default.
• W2111715662 cites W2132186730 @default.
• W2111715662 cites W2137321682 @default.
• W2111715662 cites W2141400607 @default.
• W2111715662 cites W2144410452 @default.
• W2111715662 cites W2148835789 @default.
• W2111715662 cites W2151197540 @default.
• W2111715662 cites W2159657457 @default.
• W2111715662 cites W2159876999 @default.
• W2111715662 cites W2162723667 @default.
• W2111715662 cites W2162749908 @default.
• W2111715662 cites W2167255030 @default.
• W2111715662 cites W4236254399 @default.
• W2111715662 doi "https://doi.org/10.1093/infdis/jir667" @default.
• W2111715662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3209817" @default.
• W2111715662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22021620" @default.
• W2111715662 hasPublicationYear "2011" @default.
• W2111715662 type Work @default.
• W2111715662 sameAs 2111715662 @default.
• W2111715662 citedByCount "62" @default.
• W2111715662 countsByYear W21117156622012 @default.
• W2111715662 countsByYear W21117156622013 @default.
• W2111715662 countsByYear W21117156622014 @default.
• W2111715662 countsByYear W21117156622015 @default.
• W2111715662 countsByYear W21117156622016 @default.
• W2111715662 countsByYear W21117156622017 @default.
• W2111715662 countsByYear W21117156622018 @default.
• W2111715662 countsByYear W21117156622019 @default.
• W2111715662 countsByYear W21117156622020 @default.
• W2111715662 countsByYear W21117156622021 @default.
• W2111715662 countsByYear W21117156622022 @default.
• W2111715662 countsByYear W21117156622023 @default.
• W2111715662 crossrefType "journal-article" @default.
• W2111715662 hasAuthorship W2111715662A5002830154 @default.
• W2111715662 hasAuthorship W2111715662A5033537236 @default.
• W2111715662 hasAuthorship W2111715662A5071035150 @default.
• W2111715662 hasAuthorship W2111715662A5081156604 @default.
• W2111715662 hasAuthorship W2111715662A5081960485 @default.
• W2111715662 hasAuthorship W2111715662A5082201115 @default.
• W2111715662 hasAuthorship W2111715662A5082310426 @default.
• W2111715662 hasAuthorship W2111715662A5083290723 @default.
• W2111715662 hasAuthorship W2111715662A5087696147 @default.
• W2111715662 hasBestOaLocation W21117156621 @default.
• W2111715662 hasConcept C126322002 @default.
• W2111715662 hasConcept C142462285 @default.
• W2111715662 hasConcept C159047783 @default.
• W2111715662 hasConcept C167672396 @default.

• next