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- W2111727865 abstract "Abstract The formation of disulfide bonds between thionucleotides of transfer RNA has been postulated to occur during oxidation with iodine. In this paper, the actual isolation of 4-thiouridylate disulfide from oxidized transfer RNA is described. The 5'-terminal phosphate is removed from the transfer RNA, oxidation with iodine is carried out, and the resulting product is exhaustively digested with pancreatic ribonuclease and spleen phosphodiesterase. Separation of the larger 4-thiouridylate disulfide fragment from the mononucleotides is carried out with the use of gel filtration followed by DEAE-cellulose chromatography. Reduction of the isolated disulfide product produces only 4-thiouridylate; no evidence is seen of any other nucleotides, sulfur-containing or not, having been involved in the linkage Chemically synthesized 4-thiouridine disulfide, when digested under conditions used for RNA hydrolysis, is shown to yield an unidentified intermediate which is reducible to 4-thiouridine. Alkaline digestion of 35S-labeled disulfide transfer RNA results in the appearance of the corresponding mononucleotide of this intermediate without any accompanying formation of 4-thiouridylate. Some of the properties of this new intermediate are described." @default.
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- W2111727865 date "1967-09-01" @default.
- W2111727865 modified "2023-09-30" @default.
- W2111727865 title "The Isolation of 4-Thiouridylate Disulfide from Oxidized Transfer Ribonucleic Acid of Escherichia coli" @default.
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- W2111727865 doi "https://doi.org/10.1016/s0021-9258(18)95779-0" @default.
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